Conversion of Immunodeficient Rodent Models to Excluded Flora Health Standard


     
Taconic is converting production of many immunodeficient models from the Restricted Flora™ (RF™) health standards to the Excluded Flora (EF) health profile as part of continuous quality improvements. The next model identified for conversion to Excluded Flora production is the NCr nude, with a target date for conversion by Dec 31, 2016.

To ease your transition, free trials are available through the Smart Select program. We can provide a pilot cohort of Excluded Flora NCr nude mice at no charge for you to evaluate study performance of mice at each health profile.

FAQs on Excluded Flora Health Standards


What are the differences between Excluded Flora and Restricted Flora™ health standards?
  • In addition to organisms excluded in the RF™ health standard, the EF standard excludes Proteus spp. and Segmented Filamentous Bacteria (SFB).
  • The Excluded Flora health standard, unique to Taconic, enables investigators to obtain selected Taconic mouse and rat lines that are free of seven well-documented confounding commensal organisms.

Why is Taconic converting some immunodeficient rodent lines from the RF™ to the EF standard?
  • Proteus mirabilis is a gram negative, anaerobic, rod-shaped bacterium that has become a concern for researchers working with immunodeficient rodent models.
  • In mice with immune dysfunction, Proteus mirabilis has been described as causing sepsis and may be associated with urinary tract infections.
  • Literature reports have described infections in the kidney, enlarged spleens and hepatic lesions from Proteus.
  • Segmented Filamentous Bacteria (SFB) is of particular interest for many immunology and oncology studies. SFB is not a pathogen and has not been directly associated with disease causation, however it has been shown to impact immune response.

What is the difference in price for Excluded Flora models in relation to Restricted Flora™?
  • For immunodeficient rodent models such as the NCr nude, EF and RF™ models are priced the same.
  • For immunocompetent models, the EF price is somewhat higher than the Murine Pathogen Free™ model price due to husbandry differences.

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