Immunology and Inflammation INSIGHTS


Marvel Super Heroes Take on IBD

Takeda Pharmaceuticals has joined forces with Marvel Custom Solutions to develop a graphic novel in which the super heroes have Crohn's disease or ulcerative colitis, and other characters care for family members or patients with Inflammatory Bowel Disease (IBD). As part of a Takeda program called IBD Unmasked, the graphic novel was developed in partnership with Marvel. They consulted with an IBD advisory panel consisting of patients...

Read More

AAI Travel Grant Supports GvHD Researcher

Taconic AAI 2017 travel grant awardee, Trivendra Tripathi (left) and Taconic Field Applications Scientist, Philip Dubé Taconic Biosciences awarded this year's AAI Travel Grant to Dr. Trivendra Tripathi, who presented his work on immunotherapy for graft-versus-host disease (GvHD) at the 2017 Annual Meeting of the American Association of Immunologists in Washington, DC. As a postdoctoral fellow in the lab of Dr. HyeMee Joo at the Baylor Institute...

Read More

Key Immunology Mouse Models in History

While the field of immunology has origins that date back to the 1500s, the field gained significant ground with the expanded use of mouse model systems. Fundamental discoveries elucidated in mouse models over the past 50 years are beginning to yield major breakthrough treatments for the most sinister human diseases, including inflammatory bowel disease, neurodegeneration, and cancer. The immunologist's major professional association, the American Association of Immunology,...

Read More

Versatile Applications of the TNFα Mouse

Research models are often engineered to help answer a narrow set of experimental questions; however, cross-breedings and other experimental interventions allow investigators to dramatically broaden the utility of transgenic mouse models. This is particularly true for models with strong and relatively easy-to-monitor phenotypes, two properties which support a potential platform for multiple rapid discoveries. One such example is the human TNFα mouse: a transgenic mouse that over-expresses...

Read More

What's in a Name? Origins of the CIEA NOG mouse®

The CIEA NOG mouse® is often referred to as an ideal mouse for engraftment of foreign (especially human) cells. The high rates of engraftment make NOG mice a preferred choice for patient-derived xenografts and humanized immune system mice studies. What special properties make the NOG mouse such a great acceptor of foreign cells and tissues? To answer this question, one need only look at the mouse line's...

Read More

Guidelines for Use of Humanized Mice in IBD Drug Discovery

Inflammatory Bowel Disease (IBD) is a chronic immunologically mediated disease with no known cure. Can humanized mice speed up IBD drug discovery, bringing relief to the estimated 1.4 million Americans with this difficult condition? To support IBD research, Taconic hosted a webinar by TransCure BioServices experts: Chief Executive Officer (CEO), Dr. Patrick Nef, and Chief Scientific Officer (CSO), Dr. Sebastien Tabruyn. TransCure is a contract research organization...

Read More

The Dirty Future of Immunology Animal Models

When discrepancies in immune response arise between animal models and humans, some investigators are quick to question the adequacy of laboratory mice as a proxy for human subjects. Two collaborative studies, published in Nature and Cell Host & Microbe, suggest that animal model microbiome and health standards are key to interpreting these discrepancies - and that mice with more extensive history of pathogen exposure may better model...

Read More

Review: Humanized Mouse Model Research Symposia

Humanized mouse models are critical tools for basic research, modeling of certain human-specific infectious diseases, efficacy testing of immunotherapy approaches, and safety assessment for large molecule therapeutics. Taconic Biosciences recently hosted the symposium series "Advanced Preclinical Models for Immuno-oncology and Infectious Disease" in several European cities, which focused on the latest research applications of human immune system engrafted mice and the introduction of next generation models. International...

Read More

Comparison Guide: huNOG-EXL™, NSG-SGM3 and MISTRG

Several super immunodeficient models expressing cytokines designed to drive myeloid cell lineage commitment have been generated. The most advanced cytokine transgenic mouse models are the huNOG-EXL™, NSG-SGM3 and the MISTRG. This group of models has promise to improve human immune system engraftment in mice, but each one has different features which must be considered when choosing an experimental model. Each model expresses two or more human variants...

Read More

The NOG Platform Expands - New Human Cytokine Transgenics

Dozens of papers have demonstrated the utility of the CIEA NOG mouse® for human immune system engraftment. Several systems are commonly used for human immune engraftment, each with their own advantages and disadvantages. Human hematopoietic stem cells can be engrafted to generate huNOG mice, which support long-term differentiation of multiple cell lineages. A simpler system is the huPBMC-NOG, in which mature human peripheral blood mononuclear cells are...

Read More