GEMs Management INSIGHTS


Introduction to Embryo Cryopreservation

This is the second of a four-part series on the effective use of cryopreservation in maintaining genetically modified mouse and rat lines: Cryopreservation in Colony Management Introduction to Embryo Cryopreservation Sperm Cryopreservation Overview Cryopreservation Decision Tree Embryo Cryopreservation Overview Until recently, cryopreservation of two-cell stage or later stage embryos was the predominant method for preserving lines of laboratory rodent models. The methodology is relatively simple and does...

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Cryopreservation in Colony Management

Use of genetically engineered rodent models in research requires the lines to be maintained in continuous breeding, which is costly, labor intensive, and takes up limited vivarium space. Also when such colonies are the sole source of the model, there is risk of losing the line altogether to unanticipated death, disease, infertility, genetic drift, or microbial contamination. Effective use of cryopreservation allows researchers to better utilize financial...

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The Power of Laboratory Mice Infographic

Looking for an accessible primer on the state of laboratory mice in biomedical research? Download Taconic Biosciences' new infographic The Power of Laboratory Mice, or request the infographic as a poster. This laboratory mice infographic can be a helpful reference to those just beginning their work with in vivo research models, as well as to researchers with extensive experience in the lab. It presents information on how...

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A Successful Breeding Plan in Five Steps

"It's just breeding... right?" You may want to carry out large cohort studies within the next 4-6 months, or to quickly recover a cryopreserved line from your collaborator to cross with your own knockout line. How difficult can it be? The temptation of getting there fast may make you plunge into a new project right away. But early missteps in colony management can surface months into a...

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Easier Said than Bred: 4 Considerations for Breeding Laboratory Mice

Have you ever had a mouse infestation in your house? This is a pesky problem that can prove difficult to resolve. After all, they breed like... well, mice. So why is it so difficult to breed laboratory mice? Laboratory mice are purpose-bred for specific phenotypes or traits, not to optimize litter size. Quite often, fecundity is sacrificed to attain traits desired for laboratory mouse studies, or breeding...

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Additional Mouse Models Added To The Cancer Research Technology Repository

Taconic Biosciences has recently added an additional 6 mouse lines to the Cancer Research Technology (CRT) Repository as part of the Emerging Models collection. The CRT repository provides academic and non-profit researchers with worldwide access to multiple genetically engineered mouse models that may be particularly useful for cancer research. CRT is a specialist development and commercialization company, which aims to advance new discoveries in cancer research for...

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Tbk1 Gene Function - New Model Utility

Image shows iPS derived motor neurons from an ALS patient. Tuj 1 ab shown in red and Hb9 ab in green.1 Knockout (KO) mouse models are important tools for defining mammalian gene function though it is often the case that a single gene will play different roles in different physiological contexts. A relevant example is the novel function recently attributed to the mouse TANK binding kinase 1...

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Academic Research - Pool of available GEMs increases by 75 models

Taconic Biosciences has recently added an additional 75 mouse models to the GEM Collection Repository. The GEM Collection's nearly 300 lines provide academic and nonprofit researchers worldwide with unparalleled access to a wide range of genetically engineered mouse models. These mouse models are relevant to several disease areas, such as cardiovascular, diabetes/ endocrinology, neuroscience, oncology, respiratory, and immunology. The GEM Collection repository offers nonprofit researchers immediate access...

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Additional Mouse Models Added to the Knockout Repository

Taconic Biosciences has recently added an additional 19 mouse models to the Knockout Repository (KOR). The KOR's more than 4,100 lines provide academic and commercial researchers worldwide with unparalleled access to fully licensed knockout mouse models. This repository offers the scientific community immediate access to expertly designed, highly valuable research tools that rapidly accelerate translational research and the drug discovery and development processes. Mutations are focused on...

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Taconic Biosciences Product Highlight - The Knockout Mouse Repository (KOR)

The Taconic Biosciences Knockout Mouse Repository's more than 4,100 lines provide academic and commercial researchers worldwide with unparalleled access to fully licensed knockout mouse models. This repository offers the scientific community immediate access to expertly derived, highly valuable research tools that rapidly accelerate translational research and the drug discovery and development processes. Eliminating the time associated with the design and development of these mouse models provides a...

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