TK-NOG Related Publications

Adachi K, Suemizu H, Murayama N, Shimizu M, Yamazaki H. (2015) Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling. Environ Toxicol Pharmacol. 39(3):1067-73.

Cohen J. (2014) Toxicology. 'Humanized' mouse detects deadly drug side effects. Science. 344(6181):244-5.

Grompe M, Strom S. (2013) Mice with human livers. Gastroenterology. 145(6):1209-14.

Higuchi Y, Kawai K, Yamazaki H, Nakamura M, Bree F, Guguen-Guillouzo C, Suemizu H. (2014) The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice. Xenobiotica. 44(2):146-153.

Hu Y, Wu M, Nishimura T, Zheng M, Peltz G. (2013) Human pharmacogenetic analysis in chimeric mice with 'humanized livers'. Pharmacogenet Genomics. 23(2):78-83.

Kamimura H, Ito S, Nozawa K, Nakamura S, Chijiwa H, Nagatsuka S, Kuronuma M, Ohnishi Y, Suemizu H, Ninomiya S. (2015) Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers. Drug Metab Dispos. 43(3):309-16.

Kosaka K, Hiraga N, Imamura M, Yoshimi S, Murakami E, Nakahara T, Honda Y, Ono A, Kawaoka T, Tsuge M, Abe H, Hayes CN, Miki D, Aikata H, Ochi H, Ishida Y, Tateno C, Yoshizato K, Sasaki T, Chayama K. (2013) A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections. Biochem Biophys Res Commun. 441(1):230-5.

Miyaguchi T, Suemizu H, Shimizu M, Shida S, Nishiyama S, Takano R, Murayama N, Yamazaki H. (2015) Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling. Regul Toxicol Pharmacol. 72(1):71-6.

Nishimura T, Hu Y, Wu M, Pham E, Suemizu H, Elazar M, Liu M, Idilman R, Yurdaydin C, Angus P, Stedman C, Murphy B, Glenn J, Nakamura M, Nomura T, Chen Y, Zheng M, Fitch WL, Peltzcorresponding G. (2013) Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction. J Pharmacol Exp Ther. 344(2):388-396.

Peltz G. (2013) Can 'Humanized' Mice Improve Drug Development in the 21st Century? Trends Pharmacol Sci. 34(5): 255-260.

Soulard V, Bosson-Vanga H, Lorthiois A, Roucher C, Franetich JF, Zanghi G, Bordessoulles M, Tefit M, Thellier M, Morosan S, Le Naour G, Capron F, Suemizu H, Snounou G, Moreno-Sabater A, Mazier D. (2015) Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice. Nat Commun. 6:7690.

Xu D, Michie SA, Zheng M, Takeda S, Wu M, Peltz G. (2015) Humanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: a case study with furosemide. J Pharmacol Exp Ther. 354(1):73-8.

Yamazaki H, Suemizu H, Murayama N, Utoh M, Shibata N, Nakamura M, Guengerich FP. (2013) In vivo Drug Interactions of the Teratogen Thalidomide with Midazolam: Heterotropic Cooperativity of Human Cytochrome P450 in Humanized TK-NOG Mice. Chem Res Toxicol. 26(3):486-489.

Yamazaki H, Suemizu H, Shimizu M, Igaya S, Shibata N, Nakamura M, Chowdhury G, Guengerich FP. (2012) In vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG mice. Chem Res Toxicol. 25(2): 274-276.