Trex1 Knockout Mouse Publications

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Morita M, et al.
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Morita M, Stamp G, Robins P, Dulic A, Rosewell I, Hrivnak G, Daly G, Lindahl T, Barnes DE
(2004) Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis. Mol. Cell. Biol. 24(15):6719-27
Hasan M, et al.
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Hasan M, Koch J, Rakheja D, Pattnaik AK, Brugarolas J, Dozmorov I, Levine B, Wakeland EK, Lee-Kirsch MA, Yan N
(2013) Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat. Immunol. 14(1):61-71
Gall A, et al.
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Gall A, Treuting P, Elkon KB, Loo YM, Gale M, Barber GN, Stetson DB
(2012) Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 36(1):120-31
Lindahl T, et al.
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Lindahl T, Barnes DE, Yang YG, Robins P
(2009) Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease. Biochem. Soc. Trans. 37(Pt 3):535-8
Beck-Engeser GB, et al.
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Beck-Engeser GB, Eilat D, Harrer T, Jäck HM, Wabl M
(2009) Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir. Proc. Natl. Acad. Sci. U.S.A. 106(49):20865-70
Stetson DB, et al.
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Stetson DB, Ko JS, Heidmann T, Medzhitov R
(2008) Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 134(4):587-98
Yang YG, et al.
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Yang YG, Lindahl T, Barnes DE
(2007) Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131(5):873-86