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Butchi NB, et al.
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Butchi NB, Pourciau S, Du M, Morgan TW, Peterson KE
(2008) Analysis of the neuroinflammatory response to TLR7 stimulation in the brain: comparison of multiple TLR7 and/or TLR8 agonists. J. Immunol. 180(11):7604-12
Paget C, et al.
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Paget C, Mallevaey T, Speak AO, Torres D, Fontaine J, Sheehan KC, Capron M, Ryffel B, Faveeuw C, Leite de Moraes M, Platt F, Trottein F
(2007) Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity 27(4):597-609
Anders HJ, et al.
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Anders HJ, Krug A, Pawar RD
(2008) Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus. Eur. J. Immunol. 38(7):1795-9
Fairhurst AM, et al.
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Fairhurst AM, Hwang SH, Wang A, Tian XH, Boudreaux C, Zhou XJ, Casco J, Li QZ, Connolly JE, Wakeland EK
(2008) Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Eur. J. Immunol. 38(7):1971-8
Gantier MP, et al.
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Gantier MP, Tong S, Behlke MA, Xu D, Phipps S, Foster PS, Williams BR
(2008) TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. J. Immunol. 180(4):2117-24
Hisaeda H, et al.
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Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K
(2008) Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells. J. Immunol. 180(4):2496-503
Malaria
Barrat FJ, et al.
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Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL
(2005) Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J. Exp. Med. 202(8):1131-9
Hornung V, et al.
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Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, Noronha A, Manoharan M, Akira S, de Fougerolles A, Endres S, Hartmann G
(2005) Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 11(3):263-70
Kobayashi T, et al.
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Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, Miyake K
(2008) Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice. Int. Immunol. 20(7):881-91
T And/Or B Cell Function
Delgado MA, et al.
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Delgado MA, Elmaoued RA, Davis AS, Kyei G, Deretic V
(2008) Toll-like receptors control autophagy. EMBO J. 27(7):1110-21
Zucchini N, et al.
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Zucchini N, Bessou G, Traub S, Robbins SH, Uematsu S, Akira S, Alexopoulou L, Dalod M
(2008) Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection. J. Immunol. 180(9):5799-803
Virology
Sanjuan MA, et al.
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Sanjuan MA, Dillon CP, Tait SW, Moshiach S, Dorsey F, Connell S, Komatsu M, Tanaka K, Cleveland JL, Withoff S, Green DR
(2007) Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature 450(7173):1253-7
Querec T, et al.
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Querec T, Bennouna S, Alkan S, Laouar Y, Gorden K, Flavell R, Akira S, Ahmed R, Pulendran B
(2006) Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J. Exp. Med. 203(2):413-24
Vaccine Research
Lau CM, et al.
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Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Christensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A
(2005) RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med. 202(9):1171-7
T And/Or B Cell Function
Sawaki J, et al.
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Sawaki J, Tsutsui H, Hayashi N, Yasuda K, Akira S, Tanizawa T, Nakanishi K
(2007) Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways. Int. Immunol. 19(3):311-20
NK
Wang J, et al.
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Wang J, Shao Y, Bennett TA, Shankar RA, Wightman PD, Reddy LG
(2006) The functional effects of physical interactions among Toll-like receptors 7, 8, and 9. J. Biol. Chem. 281(49):37427-34
Diebold SS, et al.
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Diebold SS, Massacrier C, Akira S, Paturel C, Morel Y, Reis e Sousa C
(2006) Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides. Eur. J. Immunol. 36(12):3256-67
Coban C, et al.
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Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S
(2007) Pathological role of Toll-like receptor signaling in cerebral malaria. Int. Immunol. 19(1):67-79
Malaria
Fink K, et al.
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Fink K, Lang KS, Manjarrez-Orduno N, Junt T, Senn BM, Holdener M, Akira S, Zinkernagel RM, Hengartner H
(2006) Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses. Eur. J. Immunol. 36(8):2094-105
T And/Or B Cell Function, Virology
Jurk M, et al.
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Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S
(2002) Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 3(6):499
Virology
Christensen SR, et al.
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Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ
(2006) Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25(3):417-28
Inflammation
Berland R, et al.
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Berland R, Fernandez L, Kari E, Han JH, Lomakin I, Akira S, Wortis HH, Kearney JF, Ucci AA, Imanishi-Kari T
(2006) Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity 25(3):429-40
T And/Or B Cell Function
Valenzuela DM, et al.
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Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, Griffiths JA, Wang X, Su H, Xue Y, Dominguez MG, Noguera I, Torres R, Macdonald LE, Stewart AF, DeChiara TM, Yancopoulos GD
(2003) High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat. Biotechnol. 21(6):652-9
Kato H, et al.
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Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S
(2005) Cell type-specific involvement of RIG-I in antiviral response. Immunity 23(1):19-28
Virology
Lang KS, et al.
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Lang KS, Recher M, Junt T, Navarini AA, Harris NL, Freigang S, Odermatt B, Conrad C, Ittner LM, Bauer S, Luther SA, Uematsu S, Akira S, Hengartner H, Zinkernagel RM
(2005) Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat. Med. 11(2):138-45
Autoimmune
Coban C, et al.
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Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S
(2005) Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J. Exp. Med. 201(1):19-25
Malaria
Hemmi H, et al.
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Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S
(2002) Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3(2):196-200
Virology
Diebold SS, et al.
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Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C
(2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303(5663):1529-31
Virology
Lund JM, et al.
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Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, Iwasaki A, Flavell RA
(2004) Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl. Acad. Sci. U.S.A. 101(15):5598-603
Virology
Heil F, et al.
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Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S
(2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303(5663):1526-9