rasH2 Publications

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Saitoh A, et al.
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Saitoh A, Kimura M, Takahashi R, Yokoyama M, Nomura T, Izawa M, Sekiya T, Nishimura S, Katsuki M		 (1990) Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. Oncogene 5(8):1195-200
Paranjpe MG, et al.
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Paranjpe MG, Belich JL, Richardson DR, Vidmar T, Mann PC, McKeon ME, Elbekai RH		 (2016) Progression of Serosal Vascular Proliferative Lesions to Hemangiosarcomas in the Uterus of the 26-Week Tg.rasH2 Mice Carcinogenicity Studies. Int. J. Toxicol.
ADMET, Tox & Safety Assessment
Yamamoto S, et al.
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Yamamoto S, Urano K, Nomura T		 (1998) Validation of transgenic mice harboring the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing. Toxicol. Lett. 102-103:473-8
Yamamoto S, et al.
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Yamamoto S, Mitsumori K, Kodama Y, Matsunuma N, Manabe S, Okamiya H, Suzuki H, Fukuda T, Sakamaki Y, Sunaga M, Nomura G, Hioki K, Wakana S, Nomura T, Hayashi Y		 (1996) Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice. Carcinogenesis 17(11):2455-61
Usui T, et al.
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Usui T, Mutai M, Hisada S, Takoaka M, Soper KA, McCullough B, Alden C		 (2001) CB6F1-rasH2 mouse: overview of available data. Toxicol Pathol 29 Suppl:90-108
Urano K, et al.
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Urano K, Suzuki S, Machida K, Sawa N, Eguchi N, Kikuchi K, Fukasawa K, Taguchi F, Usui T		 (2006) Use of IC tags in short-term carcinogenicity study on CB6F1 TGrasH2 mice. J Toxicol Sci 31(5):407-18
Takegawa K, et al.
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Takegawa K, Mitsumori K, Yasuhara K, Moriyasu M, Sakamori M, Onodera H, Hirose M, Nomura T		 (2000) A mechanistic study of ovarian carcinogenesis induced by nitrofurazone using rasH2 mice. Toxicol Pathol 28(5):649-55
Suemizu H, et al.
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Suemizu H, Muguruma K, Maruyama C, Tomisawa M, Kimura M, Hioki K, Shimozawa N, Ohnishi Y, Tamaoki N, Nomura T		 (2002) Transgene stability and features of rasH2 mice as an animal model for short-term carcinogenicity testing. Mol. Carcinog. 34(1):1-9
Ohnishi Y, et al.
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Ohnishi Y, Arai T, Koshirakawa M, Horii N, Nakajo S, Urano K, Usui T, Tamaoki N, Ueyama Y		 (2001) Induction of drug metabolism-related enzymes by methylcholanthrene and phenobarbital in transgenic mice carrying human prototype c-Ha-ras gene and their wild type littermates. Exp. Anim. 50(1):33-9
Morton D, et al.
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Morton D, Alden CL, Roth AJ, Usui T		 (2002) The Tg rasH2 mouse in cancer hazard identification. Toxicol Pathol 30(1):139-46
Mitsumori K, et al.
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Mitsumori K, Koizumi H, Nomura T, Yamamoto S		 (1998) Pathological features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for six-month carcinogenicity studies. Toxicol Pathol 26(4):520-31
Maronpot RR, et al.
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Maronpot RR, Mitsumori K, Mann P, Takaoka M, Yamamoto S, Usui T, Okamiya H, Nishikawa S, Nomura T		 (2000) Interlaboratory comparison of the CB6F1-Tg rasH2 rapid carcinogenicity testing model. Toxicology 146(2-3):149-59
Kanno H, et al.
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Kanno H, Tanakamaru ZY, Ishimura Y, Kandori H, Yamasaki H, Sasaki S		 (2003) Historical Background Data in CB6F1-Tg-rasH2 Mice and CB6F1-nonTg-rasH2 Mice over a 26-Week Experimental Period J Toxicol Pathol. 16(4):267-274
Gulezian D, et al.
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Gulezian D, Jacobson-Kram D, McCullough CB, Olson H, Recio L, Robinson D, Storer R, Tennant R, Ward JM, Neumann DA		 (2000) Use of transgenic animals for carcinogenicity testing: considerations and implications for risk assessment. Toxicol Pathol 28(3):482-99