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Yamamoto Y, et al.
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Yamamoto Y, Moore R, Hess HA, Guo GL, Gonzalez FJ, Korach KS, Maronpot RR, Negishi M
(2006) Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. J. Biol. Chem. 281(24):16625-31
Staudinger J, et al.
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Staudinger J, Liu Y, Madan A, Habeebu S, Klaassen CD
(2001) Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Drug Metab. Dispos. 29(11):1467-72
Staudinger JL, et al.
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Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA
(2001) The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc. Natl. Acad. Sci. U.S.A. 98(6):3369-74
Shah YM, et al.
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Shah YM, Ma X, Morimura K, Kim I, Gonzalez FJ
(2007) Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression. Am. J. Physiol. Gastrointest. Liver Physiol. 292(4):G1114-22
Nakamura K, et al.
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Nakamura K, Moore R, Negishi M, Sueyoshi T
(2007) Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver. J. Biol. Chem. 282(13):9768-76
Kliewer SA, et al.
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Kliewer SA, Willson TM
(2002) Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor. J. Lipid Res. 43(3):359-64
Guo GL, et al.
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Guo GL, Moffit JS, Nicol CJ, Ward JM, Aleksunes LA, Slitt AL, Kliewer SA, Manautou JE, Gonzalez FJ
(2004) Enhanced acetaminophen toxicity by activation of the pregnane X receptor. Toxicol. Sci. 82(2):374-80
Guo GL, et al.
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Guo GL, Lambert G, Negishi M, Ward JM, Brewer HB, Kliewer SA, Gonzalez FJ, Sinal CJ
(2003) Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J. Biol. Chem. 278(46):45062-71
Ding X, et al.
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Ding X, Lichti K, Kim I, Gonzalez FJ, Staudinger JL
(2006) Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha. J. Biol. Chem. 281(36):26540-51