Mdr1a/b Publications

Mdr1a/b Model Page

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Kawahara I, et al.
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Kawahara I, Nishikawa S, Yamamoto A, Kono Y, Fujita T
(2020) Assessment of contribution of BCRP to intestinal absorption of various drugs using portal-systemic blood concentration difference model in mice. Pharmacol Res Perspect 8(1):e00544
Breast Cancer
Perry A, et al.
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Perry A, Lynch RM, Rusyn I, Threadgill DW
(2019) Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes. G3 (Bethesda) 9(5):1729-1737
Safety Assessment
Agarwal S, et al.
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Agarwal S, Uchida Y, Mittapalli RK, Sane R, Terasaki T, Elmquist WF
(2012) Quantitative proteomics of transporter expression in brain capillary endothelial cells isolated from P-glycoprotein (P-gp), breast cancer resistance protein (Bcrp), and P-gp/Bcrp knockout mice. Drug Metab. Dispos. 40(6):1164-9
Schinkel AH, et al.
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Schinkel AH, Mayer U, Wagenaar E, Mol CA, van Deemter L, Smit JJ, van der Valk MA, Voordouw AC, Spits H, van Tellingen O, Zijlmans JM, Fibbe WE, Borst P
(1997) Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc. Natl. Acad. Sci. U.S.A. 94(8):4028-33
Smit JW, et al.
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Smit JW, Huisman MT, van Tellingen O, Wiltshire HR, Schinkel AH
(1999) Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. J. Clin. Invest. 104(10):1441-7
Schuetz EG, et al.
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Schuetz EG, Umbenhauer DR, Yasuda K, Brimer C, Nguyen L, Relling MV, Schuetz JD, Schinkel AH
(2000) Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes. Mol. Pharmacol. 57(1):188-97
Schinkel AH, et al.
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Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP
(1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77(4):491-502
Schinkel AH
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Schinkel AH
(1998) Pharmacological insights from P-glycoprotein knockout mice. Int J Clin Pharmacol Ther 36(1):9-13
Rao VV, et al.
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Rao VV, Dahlheimer JL, Bardgett ME, Snyder AZ, Finch RA, Sartorelli AC, Piwnica-Worms D
(1999) Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proc. Natl. Acad. Sci. U.S.A. 96(7):3900-5
Zhou S, et al.
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Zhou S, Morris JJ, Barnes Y, Lan L, Schuetz JD, Sorrentino BP
(2002) Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc. Natl. Acad. Sci. U.S.A. 99(19):12339-44
Cirrito JR, et al.
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Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM
(2005) P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J. Clin. Invest. 115(11):3285-90

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