Author(s) |
(Date) |
Paper Title |
Citation |
Model Type |
Applications |
Full Text |
| Zhang J, et al. Mouse over for full list Zhang J, Heimbach T, Scheer N, Barve A, Li W, Lin W, He H |
(2016) | Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling. | J Pharm Sci 105(4):1398-404 | |||
| Choo EF, et al. Mouse over for full list Choo EF, Woolsey S, DeMent K, Ly J, Messick K, Qin A, Takahashi R |
(2015) | Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor. | Drug Metab Dispos 43(6):864-9 | |||
| Mitsui T, et al. Mouse over for full list Mitsui T, Nemoto T, Miyake T, Nagao S, Ogawa K, Kato M, Ishigai M, Yamada H |
(2014) | A useful model capable of predicting the clearance of cytochrome 3A4 (CYP3A4) substrates in humans: validity of CYP3A4 transgenic mice lacking their own Cyp3a enzymes. | Drug Metab Dispos 42(9):1540-7 | |||
| Ly JQ, et al. Mouse over for full list Ly JQ, Messick K, Qin A, Takahashi RH, Choo EF |
(2017) | Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions. | Mol. Pharm. 14(5):1754-1759 | Humanization |
Tox & Safety Assessment | |
| RAB van Waterschoot, et al. Mouse over for full list RAB van Waterschoot, R ter Heine, E Wagenaar, CMM van der Kruijssen, RW Rooswinkel, ADR Huitema, JH Beijnen and AH Schinkel |
(2010) | Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavirbph_759 1224..1233 | British Journal of Pharmacology (2010), 160, 1224�1233 | |||
| Robert A. B. van Waterschoot, et al. Mouse over for full list Robert A. B. van Waterschoot, Rogier W. Rooswinkel, Els Wagenaar, Cornelia M. M. van der Kruijssen, Antonius E. van Herwaarden and Alfred H. Schinkel |
(2009) | Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver | The FASEB Journal | |||
| van Waterschoot RA, et al. Mouse over for full list van Waterschoot RA, Rooswinkel RW, Sparidans RW, van Herwaarden AE, Beijnen JH, Schinkel AH |
(2009) | Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam. | Drug Metab. Dispos. 37(12):2305-13 | |||
| van Herwaarden AE, et al. Mouse over for full list van Herwaarden AE, Smit JW, Sparidans RW, Wagenaar E, van der Kruijssen CM, Schellens JH, Beijnen JH, Schinkel AH |
(2005) | Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4. | Drug Metab. Dispos. 33(7):892-5 | |||
| van Herwaarden AE, et al. Mouse over for full list van Herwaarden AE, Wagenaar E, van der Kruijssen CM, van Waterschoot RA, Smit JW, Song JY, van der Valk MA, van Tellingen O, van der Hoorn JW, Rosing H, Beijnen JH, Schinkel AH |
(2007) | Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. | J. Clin. Invest. 117(11):3583-92 |
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