Humanized Liver & Gut CYP3A4 Mouse Publications

Humanized Liver & Gut CYP3A4 Mouse Model Page

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RAB van Waterschoot, et al.
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RAB van Waterschoot, R ter Heine, E Wagenaar, CMM van der Kruijssen, RW Rooswinkel, ADR Huitema, JH Beijnen and AH Schinkel
(2010) Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavirbph_759 1224..1233 British Journal of Pharmacology
Robert A. B. van Waterschoot, et al.
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Robert A. B. van Waterschoot, Rogier W. Rooswinkel, Els Wagenaar, Cornelia M. M. van der Kruijssen, Antonius E. van Herwaarden and Alfred H. Schinkel
(2009) Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver The FASEB Journal
van Waterschoot RA, et al.
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van Waterschoot RA, Rooswinkel RW, Sparidans RW, van Herwaarden AE, Beijnen JH, Schinkel AH
(2009) Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam. Drug Metab. Dispos. 37(12):2305-13
van Herwaarden AE, et al.
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van Herwaarden AE, Smit JW, Sparidans RW, Wagenaar E, van der Kruijssen CM, Schellens JH, Beijnen JH, Schinkel AH
(2005) Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4. Drug Metab. Dispos. 33(7):892-5
van Herwaarden AE, et al.
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van Herwaarden AE, Wagenaar E, van der Kruijssen CM, van Waterschoot RA, Smit JW, Song JY, van der Valk MA, van Tellingen O, van der Hoorn JW, Rosing H, Beijnen JH, Schinkel AH
(2007) Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J. Clin. Invest. 117(11):3583-92