Humanized Gut CYP3A4 Mouse Publications

Humanized Gut CYP3A4 Mouse Model Page

Filter publications by application: All
Filter publications by model type: All

Author(s)

(Date)

Paper Title

Citation

Model Type

Applications

Full Text

RAB van Waterschoot, et al.
Mouse over for full list
RAB van Waterschoot, R ter Heine, E Wagenaar, CMM van der Kruijssen, RW Rooswinkel, ADR Huitema, JH Beijnen and AH Schinkel
(2010) Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavirbph_759 1 British Journal of Pharmacology (2010), 160, 1224–1233
van Waterschoot RA, et al.
Mouse over for full list
van Waterschoot RA, Rooswinkel RW, Wagenaar E, van der Kruijssen CM, van Herwaarden AE, Schinkel AH
(2009) Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver. FASEB J. 23(1):224-31
Robert A. B. van Waterschoot, et al.
Mouse over for full list
Robert A. B. van Waterschoot, Rogier W. Rooswinkel, Rolf W. Sparidans, Antonius E. van Herwaarden, Jos H. Beijnen and Alfred H. Schinkel
(2009) Inhibition and Stimulation of Intestinal and Hepatic CYP3A Activity: Studies in Humanized CYP3A4 Transgenic Mice Using Triazolam Drug Metabolism and Disposition December 2009, 37 (12) 2305-2313
van Herwaarden AE, et al.
Mouse over for full list
van Herwaarden AE, Wagenaar E, van der Kruijssen CM, van Waterschoot RA, Smit JW, Song JY, van der Valk MA, van Tellingen O, van der Hoorn JW, Rosing H, Beijnen JH, Schinkel AH
(2007) Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J. Clin. Invest. 117(11):3583-92