APOE2 Publications

APOE2 Model Page

Filter publications by application: All Alzheimer's Cardiovascular Metabolism Neuroscience
Filter publications by model type: All Gene replacement Knock in Knock out



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Margeta MA, et al.
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Margeta MA, Yin Z, Madore C, Pitts KM, Letcher SM, Tang J, Jiang S, Gauthier CD, Silveira SR, Schroeder CM, Lad EM, Proia AD, Tanzi RE, Holtzman DM, Krasemann S, Chen DF, Butovsky O
(2022) Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. Immunity
Miranda AM, et al.
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Miranda AM, Ashok A, Chan RB, Zhou B, Xu Y, McIntire LB, Area-Gomez E, Di Paolo G, Duff KE, Oliveira TG, Nuriel T
(2022) Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice. Transl Psychiatry 12(1):129
Keeney JT, et al.
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Keeney JT, Ibrahimi S, Zhao L
(2015) Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer's Disease Prevention and Early Intervention. J Alzheimers Dis 48(2):411-24
Gene replacement
Cardiovascular, Metabolism, Alzheimer's
Wu L, et al.
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Wu L, Zhang X, Zhao L
(2018) Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention. J. Neurosci.
Jo DH, et al.
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Jo DH, Lee JH, Jun HJ, Kim J, Wen Q, Hoang MH, Yu YS, Kim JH, Lee SJ
(2015) Gene expression profiles of primary retinal pigment epithelial cells from apolipoprotein E knockout and human apolipoprotein E2 transgenic mice. Genet. Mol. Res. 14(1):1855-67
Knock out, Knock in
Tagalakis AD, et al.
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Tagalakis AD, Graham IR, Riddell DR, Dickson JG, Owen JS
(2001) Gene correction of the apolipoprotein (Apo) E2 phenotype to wild-type ApoE3 by in situ chimeraplasty. J. Biol. Chem. 276(16):13226-30
Knock in
Metabolism, Neuroscience, Alzheimer's
Malek G, et al.
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Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW, Toth CA, Sullivan PM, Bowes Rickman C
(2005) Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc. Natl. Acad. Sci. U.S.A. 102(33):11900-5
Knouff C, et al.
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Knouff C, Hinsdale ME, Mezdour H, Altenburg MK, Watanabe M, Quarfordt SH, Sullivan PM, Maeda N
(1999) Apo E structure determines VLDL clearance and atherosclerosis risk in mice. J. Clin. Invest. 103(11):1579-86
Gerritsen G, et al.
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Gerritsen G, Kypreos KE, van der Zee A, Teusink B, Zannis VI, Havekes LM, van Dijk KW
(2003) Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain. J. Lipid Res. 44(2):408-14
Sullivan PM, et al.
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Sullivan PM, Mezdour H, Quarfordt SH, Maeda N
(1998) Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J. Clin. Invest. 102(1):130-5

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