Tau - Model 1638

Tau (Model 1638) Random Transgenic Mouse Model
  • Cryopreserved
  • Mouse
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
1638STOCK Tg(Prnp-MAPT*P301L)JNPL3Hlmc
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Overview

Nomenclature: STOCK Tg(Prnp-MAPT*P301L)JNPL3Hlmc

  • Carries the transgene for the human P301L mutation of the microtubule-associated protein tau gene (MAPT)
  • Develops behavioral and motor disturbances related to development of neurofibrillary tangles (NFT)
  • Model for study of Alzheimer's disease, Pick's disease and other neurological syndromes associated with NFT
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Origin

The Tau mouse was developed in the laboratory of Mike Hutton at the Mayo Clinic. The model was created by microinjecting transgenic constructs containing the P301L mutation of the microtubule associated tau gene and mouse prion promoter into B6D2F1 x SW zygotes. The resultant mice from Founder Line JNPL3 were mated to B6D2F1. Taconic received stock in December 2000. The mice were derived by embryo transfer and mated to SW and B6D2F1 hybrids and embryo transfer derived. Offspring from both backgrounds were combined and were mated to B6D2F1 mice to produce hemizygous and wild type mice (1638). Hemizygous Tau mice were intercrossed to generate homozygous Tau mice (2508). The homozygous colony is maintained by incrossing homozygotes.

Genetics

Species:Mouse

Other Genetic Notes:

Wild type for Nnt mutation; carries Pde6brd1 mutation

Guides & Publications

Initial Publication: 

Lewis J, McGowan E, Rockwood J, Melrose H, Nacaraju P, Van Slegtenhorst M, Gwinn-Hardy K, Murphy MP, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin W-L, Yen S-H, Dickson DW, Davies P, Hutton M. (2000) Neurofibrillary Tangles, Amyotrophy and Progressive Motor Disturbance in Mice Expressing Mutant (P301L) Tau Protein. Nat Genet, 25(4):402-406.

Applications & Therapeutic Areas

  • "Alzheimers Disease"
  • Genetically Humanized
  • Neuroscience

Transit, Housing & Welfare

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