- Homozygous knockouts are highly susceptible to skin carcinoma after UV exposure.
- Useful in studies involving nucleotide excision repair (NER), DNA damage, UV- and chemically-induced skin carcinogenicity.
Genetic Background: Mixed B6 x 129S7
Origin: Developed by Sands, et al. of Baylor College of Medicine in 1995. Gene targeting took place in AB2.1 embryonic stem cells (derived from 129S7). Chimeras were mated to C57BL/6 and then intercrossed to produce homozygous knockouts.
Color: Black and Black Agouti