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Tissue specific cre deleter
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Expresses cre recombinase under the control of the Pdgfrb promoter
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Permits cre recombination in pericytes and smooth vascular muscle cells
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May be useful for angiogenesis studies
Origin:
The Pdgfrb-Cre Mouse was developed in the laboratory of Ralf Adams at the London Research Institute. The model was generated by microinjecting a transgene containing a genomic Pdgfrb promoter fragment fused to cre recombinase and a polyA sequence, into 129/B6 zygotes. Founder lines were maintained on a mixed 129;B6 background. Taconic received embryos from CRT in 2013. Source:
Sponsor: Cancer Research Technology Availability:
This model is available for immediate cryorecovery.
Species:
Mouse Initial Publication:
Foo SS, Turner CJ, Adams S, Compagni A, Aubyn D, Kogata N, Lindblom P, Shani M, Zicha D, Adams RH. (2006) Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly.
Cell. 124(1):161-73.
