Tissue specific cre deleter
Expresses cre recombinase under the control of the Pdgfrb promoter
Permits cre recombination in pericytes and smooth vascular muscle cells
May be useful for angiogenesis studies
Origin: The Pdgfrb-Cre Mouse was developed in the laboratory of Ralf Adams at the London Research Institute. The model was generated by microinjecting a transgene containing a genomic Pdgfrb promoter fragment fused to cre recombinase and a polyA sequence, into 129/B6 zygotes. Founder lines were maintained on a mixed 129;B6 background. Taconic received embryos from CRT in 2013.
Source: Sponsor: Cancer Research Technology
Availability: This model is available for immediate cryorecovery.
Foo SS, Turner CJ, Adams S, Compagni A, Aubyn D, Kogata N, Lindblom P, Shani M, Zicha D, Adams RH. (2006) Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell. 124(1):161-73