Constitutive Knockout

Oct1/2 Constitutive Knockout Mouse Model
EZcohort® Models
The easiest way to acquire and breed cryopreserved GEMs
This model is available for immediate cryorecovery.

FVB Background

  • Model #
  • Genotype
  • Nomenclature
  • 6622
    FVB.129P2-Slc22a1tm1Ahs  Slc22a2tm1Ahs N7
  • This double targeted mutation strain carries a disruption of organic cation transporter genes Slc22a1 and Slc22a2
  • Useful for studies of drug transport in the liver, intestine and kidneys
  • OCT1 and OCT2 determine renal secretion of small organic cations
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Genetic Background:

FVB Background


The Oct1/2 mouse was developed in the laboratory of Alfred Schinkel of the Netherlands Cancer Institute. The model was created through sequential targeting of the Slc22a1 and Slc22a2 genes in 129/Ola-derived E14 ES cells and injecting the targeted cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to FVB/N for seven generations (N7). Taconic received stock in 2006, and the line was embryo transfer derived. The colony was maintained by mating doubly homozygous mice.





Initial Publication:

  • Jonker JW, Wagenaar E, Mol CA, Buitelaar M, Koepsell H, Smit JW, Schinkel AH. (2001) Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene. Mol Cell Biol 21(16): 5471-5477.
  • Jonker JW, Wagenaar E, Van Eijl S, Schinkel AH. (2003) Deficiency in the organic cation transporters 1 and 2 (Oct1/2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations. Mol Cell Biol 23(21):7902-7908.

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This model is sold under terms which grant perpetual use rights.

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