Numb - Model 8976 - TG

Random Transgenic

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 8976
    C57BL/6-Tg(MMTV-hNumb) Mrl
  • The transgenic construct contains 5´ the Mouse Mammary Tumor virus (MMTV) promoter, Ki-Ras element, rabbit b-globulin intron, human NUMB cDNA, and SV40 polyA signal at 3´ end.
  • The linearized transgenic construct was microinjected in C57BL/6 mice by pronuclear injection.
  • Putative transgenic founders were identified by genotyping and bred for germline transmission with C57BL/6 mice.
  • Heterozygous transgenic mice were identified by genotyping.
  • Only low expression levels of the human transgene is detected in salivary gland, mammary gland, and lung.
  • Datamining and Design performed in 2006.

Gene Family:


Genetic Background:


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Allele Type:



Institut Clinique de la Souris (ICS), Illkirch, France


Cryopreserved at Taconic



Official Gene Name:

numb gene homolog (Drosophila)

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice mutant for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 mutant mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.

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