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The transgenic construct contains 5´ the Mouse Mammary Tumor virus (MMTV) promoter, Ki-Ras element, rabbit b-globulin intron, human NUMB cDNA, and SV40 polyA signal at 3´ end.
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The linearized transgenic construct was microinjected in C57BL/6 mice by pronuclear injection.
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Putative transgenic founders were identified by genotyping and bred for germline transmission with C57BL/6 mice.
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Heterozygous transgenic mice were identified by genotyping.
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Only low expression levels of the human transgene is detected in salivary gland, mammary gland, and lung.
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Datamining and Design performed in 2006.
Gene Family:
Phosphoprotein Genetic Background:
C57BL/6 Gene Symbol:
Numb Gene Accession Number:
NM_001136075 Allele Type:
TG Source:
Institut Clinique de la Souris (ICS), Illkirch, France Availability:
Cryopreserved at Taconic
Species:
Mouse Official Gene Name:
numb gene homolog (Drosophila)