Numb - Model 8976 - TG

• The transgenic construct contains 5´ the Mouse Mammary Tumor virus (MMTV) promoter, Ki-Ras element, rabbit b-globulin intron, human NUMB cDNA, and SV40 polyA signal at 3´ end.
• The linearized transgenic construct was microinjected in C57BL/6 mice by pronuclear injection.
• Putative transgenic founders were identified by genotyping and bred for germline transmission with C57BL/6 mice.
• Heterozygous transgenic mice were identified by genotyping.
• Only low expression levels of the human transgene is detected in salivary gland, mammary gland, and lung.
• Datamining and Design performed in 2006.

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.

• GEM Collection Commercial Terms of Sale
• GEM Collection Academic Terms of Sale

The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.

GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

• A minimum of four (4) mice heterozygous for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 heterozygous mice.
• Validated genotyping protocols
• Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.

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