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Klrd1 - Model 12666 - KO

Constitutive Knockout

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

  • Model #
  • Genotype
  • Nomenclature
  • 12666
    B6.129X1-Klrd1tm1.1lll
  • The targeting vector has been generated using 129 DNA and transfected into 129 ES cell line.
  • Klrd1 exon 3 has been disrupted and exon 4 removed by the neomycin resistance cassette, which is flanked by loxP sites.
  • The neomycin resistance gene has been deleted by transient transfection of Cre in targeted ES cells.
  • Chimeric mice were produced and germ line transmission achieved.
  • The constitutive KO line has been subsequently backcrossed to C57BL/6 animals for 9 generations.
  • Deletion of parts of exon 3 and entire exon 4 should result in loss of function of the Klrd1 gene by deleting a dimerization and the C-type lectin-like domains.
  • The remaining recombination sites are located in intron regions of the genome.
  • See M.T. Orr et al, PLoS ONE 5, e15184, 2010, for further details.

Gene Family:

Receptor

Genetic Background:

C57BL/6;129SvJ

Gene Symbol:

Klrd1

Gene Accession Number:

NM_010654

Allele Type:

KO

Source:

DNAX

Availability:

Cryopreserved at Taconic

Species:

Mouse

Official Gene Name:

killer cell lectin-like receptor, subfamily D, member 1

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO. The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
GEM Collection models exist as cryopreserved materials. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Customers will receive:

  • A minimum of four (4) mice heterozygous for the selected mutation. In rare cases where the cryopreserved material also contains a recombinase gene, this may be reduced to 1-2 heterozygous mice.
  • Validated genotyping protocols
  • Animal health report. Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard.

Please note that in rare instances (2%) cryorecovery may prove to be difficult, either extending timeline or ultimately successful recovery.

For-Profit Pricing:

Price per Line ($)
$30,000

Non-Profit Pricing:

Price per Line ($)
$5,500

For-Profit Pricing:

Price per Line (€)
€27,300

Non-Profit Pricing:

Price per Line (€)
€5,005