II4ra Knockout

Constitutive Knockout

II4ra Constitutive Knockout Mouse Model
The NIAID Exchange Program has closed and live production of this model has ceased. This webpage is retained for historical reference, but this model is not available from Taconic.

  • Model #
  • Genotype
  • Nomenclature
  • 4177-F
  • 4177-M
The alpha chain of the interleukin 4 receptor (IL-4Ra) is a subunit shared by both IL-4 and IL-13 receptors, which accounts for many of their overlapping biological functions. Thus, in contrast to an IL-4 knockout mouse, the IL-4Ra knockout blocks the function of both cytokines. Parallel studies comparing the immune responses of BALB/c IL-4 and IL-4Ra mice have revealed a unique role for IL-13 in allergic responses, and susceptibility to infection with Nippostrongylus brasiliensis, Schistosoma mansoni, and to some strains of Leishmania major parasites. While T helper 2 (Th2) are markedly diminished in IL-4Ra-/- mice, IL-4 production can readily be detected. There appears to be an IL-4-independent induction of IL-4 pathway taking place in NK T cells and also in conventional, naive CD4+ T cells.


The BALB/cJ IL-4 Ra KO mouse was generated by Nancy Noben-Trauth at Jackson Laboratory in 1997 and analyzed in the Laboratory of Immunology, NIAID, NIH with Hua Gua and William Paul. The targeting vector, which deleted exons 6-9 of the gene, was transfected into BALB/c-I ES cells (derived by Birgit Ledermann at Novartis Pharmaceuticals). The chimeric founders were crossed to BALB/cJ mice and then intercrossed to generate offspring homozygous for the targeted allele. The IL-4Ra-/- mice are therefore a genetically pure BALB/cJ strain. The line was derived by embryo transfer into the NIAID barrier facility at Taconic in 2000.


This model is no longer available.


Albino or White



Initial Publication:

Noben-Trauth N, et al.: An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice; Proc. Natl. Acad. Sci, USA, 1997:94(9):10838-43.

Noben-Trauth N, Paul WE, and Sacks DL: IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains; J. Immunolo. 1999:162(10):6132-40.

Noben-Trauth, N., J.Hu-Li, and W. E. Paul. 2000. Conventional, naïve CD4+ T cells provide an initial source of IL-4 during Th2 differentiation; J. Immunolo. 165:3620-3625.


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