Taconic Biosciences News

Taconic Biosciences News is your source for current and relevant news on how animal models are being used to drive drug discovery. Use the links below to explore exciting announcements from Taconic via Press Releases, Taconic’s press coverage in Publications and Media, and critical scientific insights within Industry News.

Beyond CRISPR: A guide to the many other ways to edit a genome

Apart from CRISPR, Nature considers alternative gene-editing tools: "The CRISPR-Cas9 tool enables scientists to alter genomes practically at will. Hailed as dramatically easier, cheaper and more versatile than previous technologies, it has blazed through labs around the world, finding new applications in medicine and basic research. But for all the devotion, CRISPR-Cas9 has its limitations. It is excellent at going to a particular location on the genome...

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Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells

Taconic Biosciences' C.B-17 scid mice are featured in this Nature article on endothelial cells: "Human endothelial cells are initiators and targets of the rejection response. Pre-operative modification of endothelial cells by small interfering RNA transfection could shape the nature of the host response post-transplantation. Ablation of endothelial cell class II major histocompatibility complex molecules by small interfering RNA targeting of class II transactivator can reduce the capacity...

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Selective Inhibition of Janus Kinase 3 Has No Impact on Infarct Size or Neurobehavioral Outcomes in Permanent Ischemic Stroke in Mice

Frontiers in Neurology discusses research performed at the University of Florida utilizing Taconic Biosciences' C57BL/6NTac mice: "Janus kinase 3 (JAK3) is associated with the common gamma chain of several interleukin (IL) receptors essential to inflammatory signaling. To study the potential role of JAK3 in stroke-induced neuroinflammation, we subjected mice to permanent middle cerebral artery occlusion and investigated the effects of JAK3 inhibition with decernotinib (VX-509) on infarct...

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Taconic Biosciences and Pharmatest Services LTD Create First Human Immune System Model for Bone Metastasis

Researchers hopeful this new model will address incurable and painful disease Hudson, NY — July 5, 2017 - Taconic Biosciences, a global leader in genetically engineered mouse models and associated services, announced it has signed a collaborative agreement with Pharmatest Services, Ltd. ("Pharmatest") to leverage the company's oncology and skeletal disease preclinical efficacy services using Taconic's humanized mouse models. Bone metastasis develops when cancer spreads from elsewhere...

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What a hunter-gatherer diet does to the body in just three days

CNN discusses how a diverse diet can influence gut health, leading to an improved microbiome in just a few days: "Mounting evidence suggests that the richer and more diverse the community of microbes in your gut the lower your risk of disease. Diet is key to maintaining diversity and was strikingly demonstrated when an undergrad student went on a McDonald's diet for ten days and after just...

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Gene Therapy: A New Twist on an Old Helix

Genetic Engineering & Biotechnology news interviews Taconic Biosciences' Dr. Adriano Flora on how "model providers can create a model of human disease to test the efficacy of the gene therapy in vivo": "What do you do when you have a chronic or even crippling disease that you happened to get just because you inherited it? As little as three decades ago, you would have been stuck with...

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BACE inhibition-dependent repair of Alzheimer's pathophysiology

This PNAS article demonstrates "that BACE inhibition is beneficial to all levels of impairment in an AD mouse model": "Amyloid-β (Aβ) is thought to play an essential pathogenic role in Alzheimer´s disease (AD). A key enzyme involved in the generation of Aβ is the β-secretase BACE, for which powerful inhibitors have been developed and are currently in use in human clinical trials. However, although BACE inhibition can...

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BeHEARD: 2016/2017 Competition Results

Taconic Biosciences is recognized as a participating company in the Rare Genomics Institute's BeHeard Competition: Teresa Luperchio, from Johns Hopkins University, will receive animal model design services from Taconic focused on Kabuki Syndrome See all of the contest winners and updates at: RareGenomics.org...

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Pulling Back the Pre-Clinical Curtain

The Translational Scientist converses with Taconic Biosciences' Portfolio Director Dr. John Couse about pre-clinical mouse models, specifically "how the shifting techniques and technologies in bioscience affect — and are affected by — mouse models": "The pre-clinical mouse model is an essential part of many translational medicine journeys, providing preliminary efficacy results that often determine if treatments are able to make the leap into clinical trials. With the...

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Mice in microgravity: how rodent research in space accelerates study timelines

Outsourcing-Pharma features Taconic Biosciences' Dr. Gretchen Kusek who discusses Taconic mice bred specifically for a mission to the International Space Station: "Forty mice were launched into space last week aboard the SpaceX Dragon, which will deliver the genetically engineered research models to the International Space Station for study in microgravity. The mission — "Rodent Research-5" — is the result of a collaboration between the University of California,...

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