Taconic Biosciences News

Taconic Biosciences News is your source for current and relevant news on how animal models are being used to drive drug discovery. Use the links below to explore exciting announcements from Taconic via Press Releases, Taconic’s press coverage in Publications and Media, and critical scientific insights within Industry News.

Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

4E-BP1 downregulation has previously been linked to cancer progression. Now in a new paper in Nature, the mechanism for 4E-BP1 expression loss has been linked to the Snail transcription factor. In vivo studies using NCr nude mice sourced from Taconic Biosciences demonstrated that inhibition of Snail activity may be a new strategy to improve efficacy of mTor-targeted chemotherapies: "Loss of 4E-BP1 expression has been linked to cancer...

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A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma

An article in Scientific Reports describes a new Hepatoblastoma mouse model, generated using patient samples and Taconic Biosciences' NOG mice: "Currently, preclinical testing of therapies for hepatoblastoma (HB) is limited to subcutaneous and intrasplenic xenograft models that do not recapitulate the hepatic tumors seen in patients. We hypothesized that injection of HB cell lines into the livers of mice would result in liver tumors that resemble their...

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Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer

BALB/c mice sourced from Taconic Biosciences contribute to advances in the treatment of epithelial ovarian cancers. Epithelial ovarian cancers are the seventh most common types of cancer in women worldwide, comprising an estimated 240,000 new cases per year and resulting in a 5-year overall survival rate that ranges from 30 to 50%. The development of novel agents with increased antitumor efficacy and limited toxicity is, thus, a...

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Enterotypes in the landscape of gut microbial community composition

Microbiome key opinion leaders revisit the concept of enteroptypes in this article in Nature Microbiology. While enterotype classification should not solely be relied upon, the authors argue why enterotypes may still be relevant and useful tools for studying the human microbiome: "Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to...

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Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines

Taconic Biosciences' BALB/c mice help scientists make a significant advance in stem-targeted influenza vaccine strategies. Each year seasonal influenza epidemics cause 3-5 million cases of severe illness and more than 250,000 deaths worldwide. In the event an antigenically novel virus emerges and initiates a pandemic, the disease burden can be much greater. Vaccination is the most effective control strategy for influenza. Due to antigenic drift and strain...

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Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse

Taconic Biosciences' hIL-15 NOG is featured in Scientific Reports: "We generated a novel mouse strain expressing transgenic human interleukin-15 (IL-15) using the severe immunodeficient NOD/Shi-scid-IL-2Rγnull (NOG) mouse genetic background (NOG-IL-15 Tg). Human natural killer (NK) cells, purified from the peripheral blood (hu-PB-NK) of normal healthy donors, proliferated when transferred into NOG-IL-15 Tg mice. In addition, the cell number increased, and the hu-PB-NK cells persisted for 3 months...

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Exosomes from antigen-pulsed dendritic cells induce stronger antigen-specific immune responses than microvesicles in vivo

Taconic Biosciences' Black 6 (B6NTac) mice help advance the understanding of the role of extracellular vesicles (EV), including exosomes and microvesicles (MV), in the rapidly expanding field of research with diagnostic and therapeutic applications for future design of vesicle-based immunotherapies and vaccines: "Extracellular vesicles (EV), including exosomes and microvesicles (MV), represent a rapidly expanding field of research with diagnostic and therapeutic applications. Although many aspects of EV...

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Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance

Cell compares the gut microbiota of wild mice and laboratory mice: "Laboratory mice, while paramount for understanding basic biological phenomena, are limited in modeling complex diseases of humans and other free-living mammals. Because the microbiome is a major factor in mammalian physiology, we aimed to identify a naturally evolved reference microbiome to better recapitulate physiological phenomena relevant in the natural world outside the laboratory." Read the summary...

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Nkx6.1 decline accompanies mitochondrial DNA reduction but subtle nucleoid size decrease in pancreatic islet β-cells of diabetic Goto Kakizaki rats

Goto-Kakizaki rats were sourced from Taconic Biosciences for this study in Nature, which elucidated previously-debated aspects of mitochondrial DNA organization: "Hypertrophic pancreatic islets (PI) of Goto Kakizaki (GK) diabetic rats contain a lower number of β-cells vs. non-diabetic Wistar rat PI. Remaining β-cells contain reduced mitochondrial (mt) DNA per nucleus (copy number), probably due to declining mtDNA replication machinery, decreased mt biogenesis or enhanced mitophagy. We confirmed...

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Expediting the Creation of Mouse Models

Dr. Kenneth Albrecht penned this article in Genetic Engineering & Biotechnology News, specifically about expediting the creation of mouse models: "Pressure to accelerate drug discovery is high, and can be impacted by how mouse models are generated and bred. This tutorial reviews the use of two techniques that, when combined, reduce the time needed to reach the experimental cohort stage when CRISPR/Cas9-mediated gene editing in embryos is...

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