Taconic Biosciences News

Taconic Biosciences News is your source for current and relevant news on how animal models are being used to drive drug discovery. Use the links below to explore exciting announcements from Taconic via Press Releases, Taconic’s press coverage in Publications and Media, and critical scientific insights within Industry News.

The microbiota protects against respiratory infection via GM-CSF signaling

Germ-free Swiss Webster mice were sourced from Taconic Biosciences for this study in Nature Communications which identified bacteria within the lung microbiome that protect against respiratory infection. The study demonstrated mechanistic pathways that can explain how these bacteria are helpful for the lung immunity: "The microbiota promotes resistance to respiratory infection, but the mechanistic basis for this is poorly defined. Here, we identify members of the microbiota...

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Lab mice's ancestral 'Eve' gets her genome sequenced

Nature interviews Taconic Biosciences' Ana Perez about Taconic Biosciences' efforts to account for genetic drift, and that Taconic plans to publish the genome of its own 'Eve': "Adam and Eve, a pair of black mice, lived for less than two years and never left their home at the Jackson Laboratory (JAX) in Bar Harbor, Maine. But since they were bred in 2005, their progeny have spread around...

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Exploring the Microbiome - with Mice

Taconic Biosciences' Alexander Maue, PhD, and Randi Lundberg, PhD composed this article regarding the relationship between rodent models and the human microbiome: "The role of the microbiome in human health is one of the hottest areas in biomedical research today. A simple PubMed search for "Microbiota and Microbiome" demonstrates a 700 percent increase in the number of relevant publications from 2009 to 2016. Perhaps unsurprisingly, a large...

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Survival of pancreatic cancer cells lacking KRAS function

Nude Mice sourced from Taconic Biosciences were utilized for this study regarding pancreatic cancer: "Activating mutations in the proto-oncogene KRAS are a hallmark of pancreatic ductal adenocarcinoma (PDAC), an aggressive malignancy with few effective therapeutic options. Despite efforts to develop KRAS-targeted drugs, the absolute dependence of PDAC cells on KRAS remains incompletely understood. Here we model complete KRAS inhibition using CRISPR/Cas-mediated genome editing and demonstrate that KRAS...

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11β-hydroxysteroid dehydrogenase type 1 has no effect on survival during experimental malaria but affects parasitemia in a parasite strain-specific manner

C57BL/6 mice from Taconic Biosciences are featured in this study in Nature: "Malaria is a global disease associated with considerable mortality and morbidity. An appropriately balanced immune response is crucial in determining the outcome of malarial infection. The glucocorticoid (GC) metabolising enzyme, 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1) converts intrinsically inert GCs into active GCs. 11β-HSD1 shapes endogenous GC action and is immunomodulatory. We investigated the role of 11β-HSD1 in...

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Microbiota from Wild Mice Protect Lab Mice from Disease

This article in Alzforum explains how bacteria from wild mice can help laboratory mice from getting diseases: "In the confines of the animal room, lab mice reared for research encounter few microbes. While this safeguards against random infections and improves experimental reproducibility, the artificially sterile environment on its own may have effects on the mice. Now, scientists led by Barbara Rehermann of the National Institute of Diabetes...

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Taconic Biosciences Launches New Tagline, Celebrating Commitment to Customers and the Microbiome

Hudson, NY — October 6, 2017 - Taconic Biosciences, a global leader in genetically engineered rodent models and associated services, announces the launch of a new tagline: "Models For Life™." Introducing a fresh interpretation of Taconic's brand and 65 year history, the new tagline celebrates Taconic's unparalleled commitment to its customers and industry leading microbiome products and services. The new 'Models For Life' tagline sits at the...

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Seres Therapeutics Reports Positive Topline Results from SER-287 Phase 1b Study in Patients with Ulcerative Colitis

Seres Therapeutics reports positive "results from SER-287 phase 1b study in Patients with Ulcerative Colitis": "Seres Therapeutics, Inc., (NASDAQ:MCRB) today announced positive topline results from a SER-287 Phase 1b placebo-controlled induction study in 58 patients with mild-to-moderate Ulcerative Colitis (UC), who were failing current therapies. Study data demonstrate that SER-287, a microbiome therapy containing a consortium of live bacterial spores, resulted in a benefit in clinical remission...

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Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy

In this article from Oncogene, research was conducted on C57BL/6 mice sourced from Taconic Biosciences: "Toll-like receptor 5 (TLR5) is considered an attractive target for anticancer immunotherapy. TLR5 agonists, bacterial flagellin and engineered flagellin derivatives, have been shown to have potent antitumor and metastasis-suppressive effects in multiple animal models and to be safe in both animals and humans. Anticancer efficacy of TLR5 agonists stems from TLR5-dependent activation...

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Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm

C57BL/6 male mice sourced from Taconic Biosciences were used for research in this article from Nature Communications: "In vivo fluorescence imaging in the near-infrared region between 1500-1700 nm (NIR-IIb window) affords high spatial resolution, deep-tissue penetration, and diminished auto-fluorescence due to the suppressed scattering of long-wavelength photons and large fluorophore Stokes shifts. However, very few NIR-IIb fluorescent probes exist currently. Here, we report the synthesis of a...

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