Taconic Biosciences News

Taconic Biosciences News is your source for current and relevant news on how animal models are being used to drive drug discovery. Use the links below to explore exciting announcements from Taconic via Press Releases, Taconic’s press coverage in Publications and Media, and critical scientific insights within Industry News.

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

Taconic Biosciences' C57BL/6, DIO C57BL/6 mice, and cryopreserved model TF3754 were featured in this study to show that recombinant GDF15 induces weight loss in mice fed a high-fat diet and in nonhuman primates with spontaneous obesity: "Growth differentiation factor 15 (GDF15), a distant member of the transforming growth factor (TGF)-ß family, is a secreted protein that circulates as a 25-kDa dimer. In humans, elevated GDF15 correlates with...

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GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

Taconic Biosciences' Sprague Dawley® rats and model TF3754 mice were used in this study showing that GDF15 binds GFRAL with high affinity: "Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-ß superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate receptor of GDF15 is unknown. Here we show that GDF15 binds specifically to GDNF family...

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The Importance of Genetic Background in Mouse Models

Dr. Philip Dubé penned this article in Biocompare, specifically about the importance of genetic background in mouse models: "The modern laboratory mouse is the result of over a century of careful breeding and selection for traits desirable in research. This effort has created hundreds of mouse strains with defined genetic backgrounds, each with unique characteristics such as coat color, behavior, metabolism, fecundity, immune function, and other physiological...

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Taconic Biosciences Plans to Relocate Headquarters to Albany, NY Area

Hudson, NY — August 23, 2017 - Taconic Biosciences announces plans to move its corporate headquarters up the Hudson River from Hudson to the Albany, NY area at the end of 2017. The new location is near several existing Taconic facilities in Rensselaer, 45 miles from its primary operations facility in Germantown, NY, and accessible to all global locations. With Taconic's increasing prominence within the global pharmaceutical...

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Taconic Biosciences Announces Partnership with Cergentis B.V. to Provide Transgene Mapping Services

Hudson, NY — August 8, 2017 - Taconic Biosciences, a global leader in genetically engineered mouse models and associated services, announced it has signed a collaborative agreement with Cergentis B.V. ("Cergentis") to leverage the company's Targeted Locus Amplification (TLA) technology to provide transgene mapping services to its customers. While transgenic mice generated via random pro-nuclear injection (PNI) continue to be a critical tool in biomedical research, a...

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Beyond CRISPR: A guide to the many other ways to edit a genome

Apart from CRISPR, Nature considers alternative gene-editing tools: "The CRISPR-Cas9 tool enables scientists to alter genomes practically at will. Hailed as dramatically easier, cheaper and more versatile than previous technologies, it has blazed through labs around the world, finding new applications in medicine and basic research. But for all the devotion, CRISPR-Cas9 has its limitations. It is excellent at going to a particular location on the genome...

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Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells

Taconic mice are featured in this Nature article on endothelial cells: "Human endothelial cells are initiators and targets of the rejection response. Pre-operative modification of endothelial cells by small interfering RNA transfection could shape the nature of the host response post-transplantation. Ablation of endothelial cell class II major histocompatibility complex molecules by small interfering RNA targeting of class II transactivator can reduce the capacity of human endothelial...

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Selective Inhibition of Janus Kinase 3 Has No Impact on Infarct Size or Neurobehavioral Outcomes in Permanent Ischemic Stroke in Mice

Frontiers in Neurology discusses research performed at the University of Florida utilizing Taconic mice: "Janus kinase 3 (JAK3) is associated with the common gamma chain of several interleukin (IL) receptors essential to inflammatory signaling. To study the potential role of JAK3 in stroke-induced neuroinflammation, we subjected mice to permanent middle cerebral artery occlusion and investigated the effects of JAK3 inhibition with decernotinib (VX-509) on infarct size, behavior,...

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Taconic Biosciences and Pharmatest Services LTD Create First Human Immune System Model for Bone Metastasis

Researchers hopeful this new model will address incurable and painful disease Hudson, NY — July 5, 2017 - Taconic Biosciences, a global leader in genetically engineered mouse models and associated services, announced it has signed a collaborative agreement with Pharmatest Services, Ltd. ("Pharmatest") to leverage the company's oncology and skeletal disease preclinical efficacy services using Taconic's humanized mouse models. Bone metastasis develops when cancer spreads from elsewhere...

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What a hunter-gatherer diet does to the body in just three days

CNN discusses how a diverse diet can influence gut health, leading to an improved microbiome in just a few days: "Mounting evidence suggests that the richer and more diverse the community of microbes in your gut the lower your risk of disease. Diet is key to maintaining diversity and was strikingly demonstrated when an undergrad student went on a McDonald's diet for ten days and after just...

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