Inflammation INSIGHTS

Endocannabinoids Prevent Inflammation, Maintain Intestinal Homeostasis

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The inflammatory bowel diseases (IBD) are conditions regulated by a combination of genetic, immune and microbial factors. Although it is a normal component of host defense against pathogens, neutrophil influx to the intestinal lumen is also associated with severe pathology in IBD. In a recent manuscript by Szabady et al., the authors demonstrate a novel role for endocannabinoid compounds in regulating intestinal inflammation by limiting neutrophil migration...  Read More

Marvel Super Heroes Take on IBD

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Takeda Pharmaceuticals has joined forces with Marvel Custom Solutions to develop a graphic novel in which the super heroes have Crohn's disease or ulcerative colitis, and other characters care for family members or patients with Inflammatory Bowel Disease (IBD). As part of a Takeda program called IBD Unmasked, the graphic novel was developed in partnership with Marvel. They consulted with an IBD advisory panel consisting of patients...  Read More

AAI Travel Grant Supports GvHD Researcher

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Taconic Biosciences awarded this year's AAI Travel Grant to Dr. Trivendra Tripathi, who presented his work on immunotherapy for graft-versus-host disease (GvHD) at the 2017 Annual Meeting of the American Association of Immunologists in Washington, DC. As a postdoctoral fellow in the lab of Dr. HyeMee Joo at the Baylor Institute for Immunology Research in Dallas, TX, Dr. Tripathi's research focuses on OX40L as a novel target...  Read More

Resuscitation Fluid Composition May Improve Sepsis Outcomes

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While modern medicine has done little to improve the mortality rates from severe sepsis, modifications in resuscitation fluid composition may prevent disease progression and improve outcomes. Researchers at McMaster University recently demonstrated that altering the concentrations of gluconate and acetate in resuscitation fluid impacts both hepatic cytokine production and leukocyte recruitment in a C57BL/6 mouse model of sepsis. "Resuscitation fluid composition affects hepatic inflammation in a murine...  Read More

Webinar Q&A — Colitis Animal Models in IBD Research

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Dr. Philip Dubé recently presented a webinar on colitis animal models for IBD research. His presentation introduced three major types of colitis models — chemically-induced, genetically engineered spontaneous colitis models, and adoptive transfer models — with examples of specific models from each type reviewed. Due to time constraints, many of the questions submitted during the webinar went unanswered. We present a full Q&A here. Dextran Sulfate Sodium...  Read More

Versatile Applications of the TNFα Mouse

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Research models are often engineered to help answer a narrow set of experimental questions; however, cross-breedings and other experimental interventions allow investigators to dramatically broaden the utility of transgenic mouse models. This is particularly true for models with strong and relatively easy-to-monitor phenotypes, two properties which support a potential platform for multiple rapid discoveries. One such example is the human TNFα mouse: a transgenic mouse that over-expresses...  Read More

The NOG Platform Expands - New Human Cytokine Transgenics

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Dozens of papers have demonstrated the utility of the CIEA NOG mouse® for human immune system engraftment. Several systems are commonly used for human immune engraftment, each with their own advantages and disadvantages. Human hematopoietic stem cells can be engrafted to generate huNOG mice, which support long-term differentiation of multiple cell lineages. A simpler system is the huPBMC-NOG, in which mature human peripheral blood mononuclear cells are...  Read More

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