Inflammation INSIGHTS

AAI Travel Grant Supports GvHD Researcher

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Taconic AAI 2017 travel grant awardee, Trivendra Tripathi (left) and Taconic Field Applications Scientist, Philip Dubé Taconic Biosciences awarded this year's AAI Travel Grant to Dr. Trivendra Tripathi, who presented his work on immunotherapy for graft-versus-host disease (GvHD) at the 2017 Annual Meeting of the American Association of Immunologists in Washington, DC. As a postdoctoral fellow in the lab of Dr. HyeMee Joo at the Baylor Institute...  Read More

Resuscitation Fluid Composition May Improve Sepsis Outcomes

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While modern medicine has done little to improve the mortality rates from severe sepsis, modifications in resuscitation fluid composition may prevent disease progression and improve outcomes. Researchers at McMaster University recently demonstrated that altering the concentrations of gluconate and acetate in resuscitation fluid impacts both hepatic cytokine production and leukocyte recruitment in a C57BL/6 mouse model of sepsis. "Resuscitation fluid composition affects hepatic inflammation in a murine...  Read More

Webinar Q&A — Colitis Animal Models in IBD Research

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Dr. Philip Dubé recently presented a webinar on colitis animal models for IBD research. His presentation introduced three major types of colitis models — chemically-induced, genetically engineered spontaneous colitis models, and adoptive transfer models — with examples of specific models from each type reviewed. Due to time constraints, many of the questions submitted during the webinar went unanswered. We present a full Q&A here. Dextran Sulfate Sodium...  Read More

Versatile Applications of the TNFα Mouse

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Research models are often engineered to help answer a narrow set of experimental questions; however, cross-breedings and other experimental interventions allow investigators to dramatically broaden the utility of transgenic mouse models. This is particularly true for models with strong and relatively easy-to-monitor phenotypes, two properties which support a potential platform for multiple rapid discoveries. One such example is the human TNFα mouse: a transgenic mouse that over-expresses...  Read More

Guidelines for Use of Humanized Mice in IBD Drug Discovery

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Inflammatory Bowel Disease (IBD) is a chronic immunologically mediated disease with no known cure. Can humanized mice speed up IBD drug discovery, bringing relief to the estimated 1.4 million Americans with this difficult condition? To support IBD research, Taconic Biosciences hosted a webinar by TransCure BioServices experts: Chief Executive Officer (CEO), Dr. Patrick Nef, and Chief Scientific Officer (CSO), Dr. Sebastien Tabruyn. TransCure is a contract research...  Read More

The NOG Platform Expands - New Human Cytokine Transgenics

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Dozens of papers have demonstrated the utility of the CIEA NOG mouse® for human immune system engraftment. Several systems are commonly used for human immune engraftment, each with their own advantages and disadvantages. Human hematopoietic stem cells can be engrafted to generate huNOG mice, which support long-term differentiation of multiple cell lineages. A simpler system is the huPBMC-NOG, in which mature human peripheral blood mononuclear cells are...  Read More