Model Generation Solutions INSIGHTS

Deflating the CRISPR/Cas9 Off-Target Controversy

photo from Deflating the CRISPR/Cas9 Off-Target Controversy

UPDATE: The paper which originally tied CRISPR/Cas 9 to off-target mutations in the mouse genome has been retracted. More information is available here. The use of CRISPR/Cas9 has profoundly affected mouse genetics by reducing the cost and the timeline associated with the introduction of mutations in the genome. But is it possible that CRISPR isn't specific enough for the generation of genetically engineered animal models? Since its...  Read More

Webinar Q&A — Your Guide to the C57BL/6 Mouse

photo from Webinar Q&A — Your Guide to the C57BL/6 Mouse

Did you miss Dr. Philip Dubé's recent webinar, The Most Important Mouse in the World - Your Guide to the C57BL/6 Mouse? His presentation explored genetic diversity amongst C57BL/6 substrains, the implications for GEM models, and the utility of the C57BL/6 mouse in studies of metabolism, immunology, oncology and behavior. Due to time constraints, many of the questions researchers submitted to his Q&A session went unanswered. Here...  Read More

Here is what CRISPR, the number 62 and pigs have in common!

photo from Here is what CRISPR, the number 62 and pigs have in common!

In December of 2015, Taconic Biosciences published an Insight titled, What do CRISPR, the number 62, and pigs have in common? In that Insight, Dr. George Church of Harvard Medical School explained that his lab had edited 62 genes in pig embryos using CRISPR-Cas9. Their goal was to make pigs better candidates as organ donors for humans. Given their close anatomical size to humans, pigs are thought...  Read More

New Vici Syndrome Mouse Model Could Accelerate Research

photo from New Vici Syndrome Mouse Model Could Accelerate Research

Most rare diseases have a genetic component, making access to an animal model with the associated gene mutation a must for developing new therapies. Yet these diseases don't often attract the funding to develop a genetically engineered model of the condition. With the help of Taconic Biosciences, two investigators studying Vici syndrome now have this essential research tool in hand. Vici syndrome is a severe congenital multisystem...  Read More

CRISPR Genome Engineering: Advantages and Limitations

photo from CRISPR Genome Engineering: Advantages and Limitations

Four years after the debut of CRISPR/Cas9 in mouse genetics, it is time to start drawing some conclusions on its performance, advantages, and limitations as a genome engineering technology1,2,3. Advantages of CRISPR Genome Engineering Arguably, the most important advantages of CRISPR/Cas9 over other genome editing technologies is its simplicity and efficiency. Since it can be applied directly in embryo, CRISPR/Cas9 reduces the time required to modify target...  Read More

Why Your Transgenic Project Failed

photo from Why Your Transgenic Project Failed

Erroneous modification of the mouse genome can lead to the generation of transgenic lines carrying non-functional alleles or unwanted mutations. These faulty models can seriously impact your research program, wasting resources on misleading results. Are Design Errors Driving Translational Failure? Genetically modified mouse models first appeared more than thirty years ago and are still at the heart of biomedical research. The first models carried relatively simple genetic...  Read More

Modeling Proprioception

photo from Modeling Proprioception

NPR recently published "How A 'Sixth Sense' Helps Simone Biles Fly, And The Rest Of Us Walk", that explored proprioception - the sense of the relative position of neighboring parts of the body - with a story on children with a rare mutation in a gene called PIEZO2. When Damiana was younger, her condition baffled doctors, says her mother, Diana Sawyer. "She was very late at doing...  Read More

Biotechnology Patents and Genetically Modified Organisms

photo from Biotechnology Patents and Genetically Modified Organisms

How do biotechnology patents affect the generation, use and distribution of genetically modified organisms, such as knockout mice or transgenic animal models? What is a licensing agreement and what are the implications of licensing (or not licensing) methods and technologies used in biomedical research? Can you use the new model you recently obtained from a collaborator for your research program? In a nutshell, patents protect intellectual property...  Read More

What do CRISPR, the number 62 and pigs have in common?

photo from What do CRISPR, the number 62 and pigs have in common?

The American Transplant Foundation reports that there are currently 123,000 people in the United States on a waiting list for an organ transplant. On average, 21 people die every day from the lack of available organs for transplant. Extending that number out to the worldwide population would put the number of people, worldwide, who need organ transplants at 2.7 million people and just under 500 people die...  Read More

Unraveling Rare Disease: Taconic's Integrated Solution Supports Vici Syndrome Research

photo from Unraveling Rare Disease: Taconic's Integrated Solution Supports Vici Syndrome Research

Rare diseases often have a genetic component, so the ability to model a genetic modification and study it in vivo is vital to understanding the disease's mechanisms and identifying therapies. As a leader in the custom development of genetically modified models, Taconic Biosciences is committed to applying our unique capabilities to advance rare disease research. We recently demonstrated that commitment by awarding a $50,000 package of integrated...  Read More

Close

Welcome! Tell us a little about yourself