Taconic Insights

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Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 65 years through our commitment to anticipating clients’ needs and industry trends. Through our Insights blog, we report on the newest research in the biopharmaceutical industry, provide expert advice regarding the maintenance of murine colonies, as well as comment on R&D and public health news.

The Complex Role of the Gut Microbiome in Human Wellness and Disease

photo from The Complex Role of the Gut Microbiome in Human Wellness and Disease

Bacteria, Archaea, and Eukarya constitute the most abundant part of the biosphere, including the plants and animals most familiar to most and an invisible world of organisms that many never consider. Although these microbes were known to exist, their diversity and functional significance within our world has not always been fully appreciated. The entire community of microorganisms that inhabit a single environment is known as a microbiome....  Read More

Challenges in Models of Myeloid Cell Engraftment in Humanized Mice

photo from Challenges in Models of Myeloid Cell Engraftment in Humanized Mice

Humanized immune system mice are revolutionary research tools for the development of novel immune cell-targeting oncology therapeutics, but the use of first-generation models such as the huNOG (NOG mice engrafted with human CD34+ hematopoietic stem cells) has been limited for some applications by impaired human myeloid cell differentiation. Several investigators sought to understand the mechanistic bottleneck and identified evolutionary disparities between mouse cytokine growth factors and human...  Read More

Biomedical Research Awareness Day 2020

photo from Biomedical Research Awareness Day 2020

Biomedical Research Awareness Day (BRAD) will be held virtually on April 16th this year due to event postponements from the ongoing COVID-19 pandemic. BRAD is sponsored by Americans for Medical Progress (AMP). This initiative is committed to educating students and the public on the importance of biomedical research and the humane use of animals. The goal is to educate people about the vital role animals play in...  Read More

Which mouse model is best for engrafting human PBMCs?

photo from Which mouse model is best for engrafting human PBMCs?

Humanized immune system mice generated by engrafting immunodeficient hosts with human peripheral blood mononuclear cells (PBMCs) have been critical tools for evaluating T-cell dependent immunotherapies. However, novel immunodeficient hosts are demonstrating their ability to extend the utility of PBMC-humanization beyond conventional T-cell focused work. The hIL-15 NOG mouse carries a transgene expressing human IL-15 and, unlike conventional immunodeficient models, has been shown to facilitate human NK cell...  Read More

Comparison Guide: huNOG-EXL, NSG-SGM3 and MISTRG

photo from Comparison Guide: <span style='text-transform: lowercase;'>hu</span>NOG-EXL, NSG-SGM3 and MISTRG

Several super immunodeficient models expressing cytokines designed to drive myeloid cell lineage commitment have been generated. The most advanced cytokine transgenic mouse models are the huNOG-EXL, NSG-SGM3 and the MISTRG. This group of models has promise to improve human immune system engraftment in mice, but each one has different features which must be considered when choosing an experimental model. Each model expresses two or more human variants...  Read More

An Overview of Mouse Models for COVID-19

photo from An Overview of Mouse Models for COVID-19

COVID-19 is rapidly spreading around the globe and constitutes a global health crisis. This disease is caused by the SARS-CoV-2 virus, a coronavirus related to the SARS-CoV virus which caused the global SARS outbreak in 20031,2. Preclinical research on SARS may provide insight into useful animal models for COVID-19 research, and much of the information presented below is based on studies of SARS. While there is little...  Read More

The Translational Relevance of IBD Mouse Models

photo from The Translational Relevance of IBD Mouse Models

Many animal models have been developed to study inflammatory bowel disease (IBD), and they remain in general use for screening of potential new therapies. But a recent review article questions the relevance of many of these models, citing evidence that they may not accurately predict therapeutic response in patients. Background: Types of Rodent Colitis Models Colitis models are commonly grouped into three categories: Chemically-induced colitis: Chemicals such...  Read More

NASH Research Updates in 2020

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Nonalcoholic steatohepatitis (NASH) continues to be a hot topic in metabolic disease research. The NASH research field gathers twice a year at major conferences: The Liver Meeting is organized by the American Association for the Study of Liver Diseases (AASLD) in the US in the Autumn. International Liver Congress is organized by the European Association for the Study of the Liver (EASL) in Europe every Spring. What...  Read More

Webinar Q&A — Microbiological Monitoring of Germ-Free and Gnotobiotic Colonies

photo from Webinar Q&A — Microbiological Monitoring of Germ-Free and Gnotobiotic Colonies

Dr. Paula Roesch recently presented a webinar on microbiological monitoring of germ-free and gnotobiotic colonies. Taconic Biosciences has decades of experience in this area and Dr. Roesch presented a thorough look at all aspects of the process, starting from tools and approaches to process validation and monitoring and moving into isolator monitoring techniques. She even included lessons learned from a case study where things didn't go as...  Read More

New Rab29 Overexpression Mouse Model for Parkinson's Disease

photo from New Rab29 Overexpression Mouse Model for Parkinson's Disease

Parkinson's disease (PD) is the second most common neurodegenerative disease (after Alzheimer's disease) and the most common movement disorder. The worldwide incidence of PD has more than doubled since 1990 to an estimated 6.1 million PD patients globally in 20161. In the United States in 2017, the estimated total economic burden of PD was $51.9 billion (The Lewin Group, Inc., Final Report commissioned by and submitted to...  Read More

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