Taconic Insights

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Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 65 years through our commitment to anticipating clients’ needs and industry trends. Through our Insights blog, we report on the newest research in the biopharmaceutical industry, provide expert advice regarding the maintenance of murine colonies, as well as comment on R&D and public health news.

Understanding Malocclusion in Research Mice

photo from Understanding Malocclusion in Research Mice

The word rodent is derived from the Latin word rodere, which means "to gnaw". This process of gnawing brings to light common dental maladies that are of paramount importance to animal welfare. One specific condition is called malocclusion, which is caused by the misalignment of the incisors and may involve overgrowth of the molars or cheek teeth. If untreated, teeth will overgrow and prevent the rodent from...  Read More

Microbial Metabolism of Bile Acids Contributes to Immunological Balance in the Colon

photo from Microbial Metabolism of Bile Acids Contributes to Immunological Balance in the Colon

Regulatory T (Treg) lymphocytes play an essential role in maintaining homeostasis of the immune system. Characterized by expression of the forkhead box transcription factor (Foxp3), populations of Tregs are divided into two subsets: thymus-derived, or natural Treg cells (nTreg), peripheral Treg cells (pTreg), or induced Treg cells that arise extrathymically1. Both subsets work to maintain immune balance by limiting excessive effector responses and providing immune tolerance to...  Read More

Aged Inbred Mice May Advance Research Into Age-Related Mortality in Coronavirus Infections

photo from Aged Inbred Mice May Advance Research Into Age-Related Mortality in Coronavirus Infections

Author note: at the publication date for this Insight, mouse-adapted SARS-CoV-2 viral strains were not available. However, two papers published after this Insight have demonstrated two different approaches for developing these mouse-adapted viral strains. Taconic has published a new Insight discussing this research. COVID-19, caused by the SARS-CoV-2 virus, is rapidly spreading over the globe. On March 11th, 2020, the WHO declared this outbreak a pandemic, and...  Read More

2020 Society of Toxicology (SOT) Annual Meeting has Gone Virtual

photo from 2020 Society of Toxicology (SOT) Annual Meeting has Gone Virtual

As with many 2020 scientific meetings and events, the Society of Toxicology (SOT) Annual Meeting was canceled as an in-person event due to the ongoing COVID-19 pandemic. However, SOT has organized a robust offering of online content as a replacement. While nothing beats the energy of a live scientific meeting, the virtual format is available to a broader audience of attendees globally. Visit the 2020 SOT Virtual...  Read More

Knockout Mice for the Study of Coronavirus Infections

photo from Knockout Mice for the Study of Coronavirus Infections

The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2, COVID-19), and its rapid international spread pose a global health emergency. The SARS-CoV-2 virus belongs to the family of coronaviridae viruses, which are enveloped, positive-sense, single-stranded RNA viruses. Entry into human (mammalian) cells depends on binding of the viral spike (S) proteins to human cellular receptors and on S protein priming by host cell proteases. Patients with...  Read More

Taconic Biosciences Learn at Home Series: Oncology

photo from Taconic Biosciences Learn at Home Series: Oncology

With many researchers and laboratory animal professionals under orders to remain at home to limit the spread of coronavirus, we know you may have a bit more time on your hands than usual. To help keep you engaged while working from home, Taconic Biosciences has pulled together a series of educational materials organized around different therapeutic areas. The first track is available now, with additional tracks available...  Read More

Safety Testing Critical for COVID-19 Therapies and Vaccines

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"We must urgently develop measures to tackle the new coronavirus -- but safety always comes first." 1Dr. Shibo Jiang As COVID-19 deaths rise and the world economy continues to take devastating hits, countries, states, and cities are desperate for anything that can provide relief. Dr. Jiang, professor of virology at Fudan University, notes that, "combating this disease demands a vaccine that is safe and potent. The fatality...  Read More

Mouse Behavior Impacts the Composition of the Small Intestinal Microbiome and Bile Acid Profile

photo from Mouse Behavior Impacts the Composition of the Small Intestinal Microbiome and Bile Acid Profile

Mice remain the most utilized animal model within microbiome research. The advantages of using mouse models are clear with regard to homogenous genetics, accessibility to germ-free, mutant and/or transgenic models, a comparable physiology and the relatively low cost of performing studies. In addition, the use of mouse models has been key in landmark studies determining the role of the gut microbiota in various diseases. Despite the clear...  Read More

The Complex Role of the Gut Microbiome in Human Wellness and Disease

photo from The Complex Role of the Gut Microbiome in Human Wellness and Disease

Bacteria, Archaea, and Eukarya constitute the most abundant part of the biosphere, including the plants and animals most familiar to most and an invisible world of organisms that many never consider. Although these microbes were known to exist, their diversity and functional significance within our world has not always been fully appreciated. The entire community of microorganisms that inhabit a single environment is known as a microbiome....  Read More

Challenges in Models of Myeloid Cell Engraftment in Humanized Mice

photo from Challenges in Models of Myeloid Cell Engraftment in Humanized Mice

Humanized immune system mice are revolutionary research tools for the development of novel immune cell-targeting oncology therapeutics, but the use of first-generation models such as the huNOG (NOG mice engrafted with human CD34+ hematopoietic stem cells) has been limited for some applications by impaired human myeloid cell differentiation. Several investigators sought to understand the mechanistic bottleneck and identified evolutionary disparities between mouse cytokine growth factors and human...  Read More

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