Taconic Biosciences News

Taconic Biosciences News is your source for current and relevant news on how animal models are being used to drive drug discovery. Use the links below to explore exciting announcements from Taconic via Press Releases, Taconic’s press coverage in Publications and Media, and critical scientific insights within Industry News.

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

Taconic Biosciences was featured in the Journal of Pharmacology and Experimental Therapeutics, in which its knock-in mice were used: "Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptor potentiator DETQ [2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one]. In human embryonic kidney 293 (HEK293) cells expressing the human D1 receptor, DETQ induced a 21-fold leftward shift...

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Rebalancing gut microbiome lengthens survival in mouse model of ALS

Medical Xpress discusses how researchers using a mouse model of ALS have found ways to help correct gut microbiome imbalance symptoms, which stem from ALS: "A bacterial by-product known to be important in maintaining gut health may slow the progression of amyotrophic lateral sclerosis, or ALS - a progressive, neurodegenerative disease. Researchers at the University of Illinois at Chicago College of Medicine report that in a mouse...

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Microbiome Science Could Bring a Revolution in Medical Care

NBC News talks over evolving microbiome science and how it is impacting medical care: "The human body is made up of roughly 10 trillion cells. That's a huge number, but it's dwarfed by the 40 trillion or so bacterial cells that live on and inside the body. In recent years, scientists have learned that our bacteria -- known collectively as the microbiome -- are intimately involved with...

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Microbiota composition of simultaneously colonized mice housed under either a gnotobiotic isolator or individually ventilated cage regime

Nature discusses gnotobiotic isolators compared to individually ventilated cages, and how microbiotas are protected in either housing system: "Germ-free rodents colonized with microbiotas of interest are used for host-microbiota investigations and for testing microbiota-targeted therapeutic candidates. Traditionally, isolators are used for housing such gnotobiotic rodents due to optimal protection from the environment, but research groups focused on the microbiome are increasingly combining or substituting isolator housing with...

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A Gut Makeover for the New Year

NY Times weighs in on new year's resolutions – specifically in regards to a new study which suggests that changing your eating habits can benefit your gut microbiota: "If you're making resolutions for a healthier new year, consider a gut makeover. Refashioning the community of bacteria and other microbes living in your intestinal tract, collectively known as the gut microbiome, could be a good long-term investment in...

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Protein that activates immune response harms body's ability to fight HIV

Science Daily discusses that temporarily blocking a type of protein can restore immune function and more for people with chronic infection of the virus that causes AIDS: "In findings they call counterintuitive, a team of UCLA-led researchers suggests that blocking a protein, which is crucial to initiating the immune response against viral infections, may actually help combat HIV. Findings from a study in animals appear to demonstrate...

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Taconic Biosciences Accounces All US and EU Rat Colonies Free of Rat Polyomavirus 2

Hudson, NY, - December 14, 2016 - Taconic Biosciences, a leading provider of genetically engineered mouse models and associated services to researchers worldwide, today announced that all US and European commercial rat colonies are free of a newly discovered agent. IDEXX BioResearch announced it has identified rat polyomavirus 2, a novel virus, at the 2016 American Association for Laboratory Animal Science National Meeting in Charlotte, NC. According...

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Cleveland Clinic Unveils Top 10 Medical Innovations Most Likely To Be Game Changers

Cleveland Clinic's Newsroom details their top ten choices of medical innovations from 2016: "A panel of top doctors and researchers presents the advancements with the power to transform healthcare in 2017 Smart cars that reduce accidents and injuries. Immunotherapy that helps kids beat cancer without chemo. Stents that harmlessly dissolve when their work is done. These are some of the innovations that will enhance healing and change...

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Humanizing Animals for Immuno-Oncology

Genetic Engineering & Biotechnology features Taconic Biosciences because of their expertise with Immuno-Oncology and Humanized mouse models: "Success in Humanizing Mice Has Inspired Similar Efforts in Rats, Pigs, and Other Animals. One of the major roadblocks to curing cancer is modeling the complexities of the disease; thus, increasingly refined models of the disease are necessary. The result has been a sizable increase in the number of genetically...

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Guest Commentary: What if mice could be more like humans?

Dr. Michael Seiler is the author of this DDNews article because of his knowledge surrounding humanized mouse models, immuno-oncology, and genetically engineered mouse models: "Throughout their decades of use in medical research, there exist numerous examples where mice have failed to adequately parallel human biology, leading to considerable wastes of money, time and effort. Nevertheless, questioning the adequacy of mice as human surrogates remains controversial, in large...

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