Taconic Biosciences News

Taconic Biosciences News is your source for current and relevant news on how animal models are being used to drive drug discovery. Use the links below to explore exciting announcements from Taconic via Press Releases, Taconic’s press coverage in Publications and Media, and critical scientific insights within Industry News.

Targeting Gut Bacteria May Be The Key To Preventing Alzheimer's

Huffington Post speaks of a new study which proposes a link between the brain and how a gut-healthy diet could help prevent the development of Alzheimer's disease: "Mounting research continues to show the links between the health of the gut and that of the brain. Now, a new study from Lund University in Sweden finds that unhealthy intestinal flora can accelerate the development of Alzheimer's disease. The...

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Taconic Biosciences Generates Vici Syndrome Mouse Model

CRISPR Accelerates Availability of Vital Research Tool Hudson, NY - February 17, 2017 - Taconic Biosciences, a global leader in genetically engineered rodent models and associated services, announced it has generated a novel mouse model of Vici syndrome for use by two investigators studying this rare disease. As a corporate sponsor of the Rare Disease Science Challenge: BeHEARD, hosted by the Rare Genomics Institute, Taconic donated model...

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Mouse model program looks to speed drug discovery

Outsourcing-Pharma discusses the EZcohort™ program launched at Taconic Biosciences: "According to the company, the EZcohort™ program was developed in response to "a need for speed and predictability in drug discovery." Dr. Michael Seiler, portfolio director, Commercial Genetically Engineered Models, Taconic Biosciences, told us the company has "innovated in the transactional space." "Instead of requiring materials transfer agreements, as many repository vendors do, we sell these under a...

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Taconic Biosciences Launches New EZcohort™ Program Improving Access to Mouse Models

Hudson, NY - February 8, 2017 - Taconic Biosciences, a global leader in genetically engineered murine models and associated services, announced the launch of the EZcohort™ program, providing researchers faster and easier access to unique mouse models. In response to the need for speed and predictability in drug discovery, the EZcohort™ program leverages simplified legal documentation and common cohort sizes, allowing researchers to easily access unique cryopreserved...

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An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

Taconic was featured in the Journal of Pharmacology and Experimental Therapeutics, in which its knock-in mice were used: "Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptor potentiator DETQ [2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one]. In human embryonic kidney 293 (HEK293) cells expressing the human D1 receptor, DETQ induced a 21-fold leftward shift in...

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Rebalancing gut microbiome lengthens survival in mouse model of ALS

Medical Xpress discusses how researchers using a mouse model of ALS have found ways to help correct gut microbiome imbalance symptoms, which stem from ALS: "A bacterial by-product known to be important in maintaining gut health may slow the progression of amyotrophic lateral sclerosis, or ALS - a progressive, neurodegenerative disease. Researchers at the University of Illinois at Chicago College of Medicine report that in a mouse...

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Microbiome Science Could Bring a Revolution in Medical Care

NBC News talks over evolving Microbiome science and how it is impacting medical care: "The human body is made up of roughly 10 trillion cells. That's a huge number, but it's dwarfed by the 40 trillion or so bacterial cells that live on and inside the body. In recent years, scientists have learned that our bacteria -- known collectively as the microbiome -- are intimately involved with...

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Microbiota composition of simultaneously colonized mice housed under either a gnotobiotic isolator or individually ventilated cage regime

Nature discusses gnotobiotic isolators compared to individually ventilated cages, and how microbiotas are protected in either housing system: "Germ-free rodents colonized with microbiotas of interest are used for host-microbiota investigations and for testing microbiota-targeted therapeutic candidates. Traditionally, isolators are used for housing such gnotobiotic rodents due to optimal protection from the environment, but research groups focused on the microbiome are increasingly combining or substituting isolator housing with...

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A Gut Makeover for the New Year

NY Times weighs in on new year's resolutions – specifically in regards to a new study which suggests that changing your eating habits can benefit your gut microbiota: "If you're making resolutions for a healthier new year, consider a gut makeover. Refashioning the community of bacteria and other microbes living in your intestinal tract, collectively known as the gut microbiome, could be a good long-term investment in...

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Protein that activates immune response harms body's ability to fight HIV

Science Daily discusses that temporarily blocking a type of protein can restore immune function and more for people with chronic infection of the virus that causes AIDS: "In findings they call counterintuitive, a team of UCLA-led researchers suggests that blocking a protein, which is crucial to initiating the immune response against viral infections, may actually help combat HIV. Findings from a study in animals appear to demonstrate...

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