Neuroscience INSIGHTS

A Redox Link between APOE4 and Alzheimer's Disease Risk?

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A Redox Link between APOE4 and Alzheimer's Disease Risk? Individuals homozygous for APOE4, one of three common genetic variants encoding Apolipoprotein E (apoE), carry approximately twelve-times higher risk for an Alzheimer's disease (AD) diagnosis. A recent study suggests a potentially critical link between apoE4 and the antioxidant enzyme Thioredoxin-1 (Trx1) may underlie enhanced AD risk in APOE4 carriers. APOE Alleles Modify Alzheimer's Risk ApoE protein is predominantly...  Read More

Chronic Pain Management Research and the Opioid Crisis

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Developing novel drugs for chronic pain management — both more effective and less addictive than opioids — will reduce the number of patients at risk of opioid dependence. Chronic Pain and the Opioid Crisis More than 25% of Americans suffer from chronic pain. This is on par with adults from equivalent regions; between 10-25% of adults in other western countries experience chronic pain, while some estimates of...  Read More

Animal Models of Addiction and the Opioid Crisis

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As the opioid crisis continues, every week brings new and alarming developments, legislative attempts to address the epidemic, and new formulations of street drugs which are contaminated, or resistant to naloxone. This has sparked a variety of debates concerning how we can best address the situation. From a public health perspective, however, the need to explore relevant and predictive animal models of addiction and develop novel strategies...  Read More

Webinar Q&A — CNV Psychiatric Disease Models

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Dr. Michael Didriksen, whose work with Lundbeck Pharmaceuticals is bridging preclinical and clinical schizophrenia and psychosis science, presented a webinar focused on the application of three novel psychiatric disease models, all carrying high-risk genetic copy number variations (CNVs). His presentation on the research applications of mice carrying high-risk CNVs generated substantial interest from the neuropsychiatric community. Here are some of the most popular questions we received from...  Read More

Generating EAE Mouse Models of Multiple Sclerosis

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Experimental Autoimmune Encephalomyelitis (EAE) is a widely-accepted model of demyelinating diseases, such as multiple sclerosis (MS). How can you most efficiently generate EAE mouse models of multiple sclerosis and which mouse strains work best for this application? Although the exact details are not understood, the immune system is involved in MS pathogenesis. Like MS, EAE is characterized by infiltration of immune cells into the central nervous system...  Read More

Targeting APOE4 for Alzheimer's Disease Therapies

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Past research efforts, focused on Alzheimer's disease (AD) pathology and the genetics of familial AD, led to the discovery of important AD-related proteins, including amyloid-beta (Aβ) and tau. However, efforts to develop AD therapies based on targeting Aβ and tau have largely failed. Years of disappointing trials have brought increasing demand for new AD targets and alternative treatment approaches. Using mice expressing apolipoprotein E4 (apoE4), a human...  Read More

Society for Neuroscience 2016 Abstracts - By the Numbers

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In a little less than a month, 30,000 scientists will gather in San Diego for Society for Neuroscience 2016 Annual Meeting. Over 15,000 abstracts have been accepted for presentations in symposia, mini-symposia, and posters. There will be more than 100 satellite events being held in conjunction with the annual meeting with at least 600 exhibitors showcasing new tools and technologies. The volume of information and insight on...  Read More

Copy Number Variation, Microdeletion, and Disease

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Copy number variations (CNVs) are duplications and deletions to large (~5kb-5mb) genomic regions found in varying degrees within the human population. These duplications and deletions significantly contribute to human genetic diversity and can dramatically affect gene-dosage. Recently, pathologic and highly-penetrant CNVs have been identified in patients with neurodevelopmental and psychiatric disorders. The microdeletion at chromosome location 15q13.3 is one example. This CNV can result in a range...  Read More

Tbk1 Gene Function - New Model Utility

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Image shows iPS derived motor neurons from an ALS patient. Tuj 1 ab shown in red and Hb9 ab in green.1 Knockout (KO) mouse models are important tools for defining mammalian gene function though it is often the case that a single gene will play different roles in different physiological contexts. A relevant example is the novel function recently attributed to the mouse TANK binding kinase 1...  Read More