Model Generation Solutions INSIGHTS

Why Your Transgenic Project Failed

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Erroneous modification of the mouse genome can lead to the generation of transgenic lines carrying non-functional alleles or unwanted mutations. These faulty models can seriously impact your research program, wasting resources on misleading results. Are Design Errors Driving Translational Failure? Genetically modified mouse models first appeared more than thirty years ago and are still at the heart of biomedical research. The first models carried relatively simple genetic...  Read More

Modeling Proprioception

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NPR recently published "How A 'Sixth Sense' Helps Simone Biles Fly, And The Rest Of Us Walk", that explored proprioception - the sense of the relative position of neighboring parts of the body - with a story on children with a rare mutation in a gene called PIEZO2. When Damiana was younger, her condition baffled doctors, says her mother, Diana Sawyer. "She was very late at doing...  Read More

Biotechnology Patents and Genetically Modified Organisms

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How do biotechnology patents affect the generation, use and distribution of genetically modified organisms, such as knockout mice or transgenic animal models? What is a licensing agreement and what are the implications of licensing (or not licensing) methods and technologies used in biomedical research? Can you use the new model you recently obtained from a collaborator for your research program? In a nutshell, patents protect intellectual property...  Read More

What do CRISPR, the number 62 and pigs have in common?

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The American Transplant Foundation reports that there are currently 123,000 people in the United States on a waiting list for an organ transplant. On average, 21 people die every day from the lack of available organs for transplant. Extending that number out to the worldwide population would put the number of people, worldwide, who need organ transplants at 2.7 million people and just under 500 people die...  Read More

Unraveling Rare Disease: Taconic's Integrated Solution Supports Vici Syndrome Research

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Rare diseases often have a genetic component, so the ability to model a genetic modification and study it in vivo is vital to understanding the disease's mechanisms and identifying therapies. As a leader in the custom development of genetically modified models, Taconic Biosciences is committed to applying our unique capabilities to advance rare disease research. We recently demonstrated that commitment by awarding a $50,000 package of integrated...  Read More

Taconic Biosciences' Support Helps To Advance Rare Disease Research

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Taconic Biosciences is partnering again with the Rare Genomics Institute (RGI) to support the 2015 Rare Disease Science Challenge: Be HEARD (Helping Empower and Accelerate Research Discoveries). As a sponsor of the Rare Disease Challenge in 2014, Taconic donated custom generation of a genetically engineered mouse model that is now being used to study Sanfilippo disease through a grant from the National Institutes of Health (NIH). This...  Read More