Microbiome and Germ-Free INSIGHTS

LEM1 C. difficile Strain Prevents Pathogenic Infection

photo from LEM1 <em>C. difficile</em> Strain Prevents Pathogenic Infection

Researchers at Georgia State University made a surprising discovery1 while establishing a mouse model of C. difficile infection: a novel, endogenous strain of the bacteria which blooms after antibiotic therapy and protects its host from disease. This could potentially confound experimental results, as the LEM1 strain is inconsistently present among mouse model vendors. C. difficile Genes Appearing Prior to Infection To establish their model, the researchers treated...  Read More

Baby Formula Feeding and the Infant Microbiome

photo from Baby Formula Feeding and the Infant Microbiome

Breastfeeding versus formula feeding of infants can be a controversial subject. Those who believe the "breast is best" may be interested in a new study which reports that components in infant formula modify the establishment of a baby's gut microbiota. How Formula Affects the Infant Microbiome Earlier research has shown that gut microbiome varies between formula-fed and breast-fed infants. Now, researchers from the Technical University of Denmark...  Read More

Are Dirty Mice Superior Immunology Models?

photo from Are Dirty Mice Superior Immunology Models?

In a recent review article, David Masopust and his coauthors from the University of Minnesota Medical School discuss the relevancy of mouse models for use in immunological studies and translatability of immune system studies using SPF mice. Of Mice, Dirty Mice, and Men: Using Mice to Understand Human Immunology1 provides a short introduction to the development of the laboratory mouse while calling out a number of significant...  Read More

2017 Microbiome in Mouse Models Workshop Review — Best Practices

photo from 2017 Microbiome in Mouse Models Workshop Review — Best Practices

Part III: Best Practices for Study Design This is the third of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference. Part I: Participants and Presentations Part II: Microbiome Workshop Topics Part III: Best Practices for Study Design In this Insight, we will summarize the main findings of workshop...  Read More

2017 Microbiome in Mouse Models Workshop Review — Key Topics

photo from 2017 Microbiome in Mouse Models Workshop Review — Key Topics

Part II: Microbiome Workshop Topics This is the second of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference. Part I: Participants and Presentations Part II: Microbiome Workshop Topics Part III: Best Practices for Study Design In this Insight, we recap workshop topics and discussions relating to the use...  Read More

2017 Microbiome in Mouse Models Workshop Review

photo from 2017 Microbiome in Mouse Models Workshop Review

Part I: Participants and Presentations This is the first of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference. Part I: Participants and Presentations Part II: Microbiome Workshop Topics Part III: Best Practices for Study Design Participating Scientists The microbiome workshop was led by Alexander Maue, PhD, director of...  Read More

HIV Drug Efficacy Affected by Microbiome Composition

photo from HIV Drug Efficacy Affected by Microbiome Composition

The metabolism of pharmacological compounds by our inhabitant microbes can have a significant effect on drug efficacy. While the best-known example may be the inactivation of the drug digoxin by gut flora1, Klatt et al. recently demonstrated that an imbalance in the healthy vaginal microbiome impacts the efficacy of a human immunodeficiency virus (HIV) drug2. Efficacy of Tenofovir Gel Affected by Vaginal Microbiome Composition Tenofovir is a...  Read More

Can Anxiety Phenotypes Transfer via FMT?

photo from Can Anxiety Phenotypes Transfer via FMT?

Connections between behavioral phenotypes and the microbiome continue to emerge from fecal microbiota transplantation (FMT) studies at McMaster University. Can Behavioral Phenotypes Be Transferred? Researchers at McMaster University first demonstrated the transfer of behavioral traits between mice via the gut microbiome by fecal microbiota transplantation (FMT) in 2011. The authors exploited the observation that two strains of mice, inbred BALB/c and outbred NIH Swiss mice with differing...  Read More

Murine Lung Microbiome Webinar Recap

photo from Murine Lung Microbiome Webinar Recap

On June 8, Dr. Kenneth Klingenberg Barfod — of the National Research Centre for the Working Environment, Denmark — presented a webinar on the importance of the murine lung microbiome, how the lung microbiome in mice can be manipulated experimentally, and its applications in disease modeling. Compared to the extensively studied gut microbiome, the lung microbiome is a niche research area with relatively few published reports. A...  Read More

The Medicinal Microbiome: Presentations of Note

photo from The Medicinal Microbiome: Presentations of Note

A growing number of scientists are investigating the role of our microbiome in the development of and protection from disease. One area of particular interest is recovery from injury and infection. Recent publications examine the relationship between the microbiome and HIV infection (Wei Yang JS, 2017), harnessing microbiome targeted therapies to reduce post-operative complications (Kasatpibal N, 2017), and the impact of environmental toxins on increasing antimicrobial resistant...  Read More