Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

The Microbiome and Visceral Pain

The gut microbiome may contribute to or modulate the pain of visceral hypersensitivity, but how the microbiome affects neurotransmission, pain perception, and GI function is not well understood. Pokusaeva and colleagues hypothesized that production of the neurotransmitter γ-aminobutyric acid (GABA) by gut bacteria such as Lactobacillus and Bifidobacterium might be one mechanism through which the microbiome-gut-brain axis functions to modulate visceral pain. Connecting the Microbiome and Visceral...

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Efficacy Studies in Humanized Mice from AACR 2017

Mice engrafted with a human immune system — HIS or humanized mice — have secured important roles as efficacy models in the immuno-oncology therapeutic development pipeline. Several impressive examples of efficacy studies in humanized mice were on display at the 2017 American Association for Cancer Research (AACR) meeting. Efficacy Studies in Humanized Mice at AACR 2017 Upon engraftment of human peripheral blood mononuclear cells (PBMCs), super-immunodeficient models,...

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AAI Travel Grant Supports GvHD Researcher

Taconic AAI 2017 travel grant awardee, Trivendra Tripathi (left) and Taconic Field Applications Scientist, Philip Dubé Taconic Biosciences awarded this year's AAI Travel Grant to Dr. Trivendra Tripathi, who presented his work on immunotherapy for graft-versus-host disease (GvHD) at the 2017 Annual Meeting of the American Association of Immunologists in Washington, DC. As a postdoctoral fellow in the lab of Dr. HyeMee Joo at the Baylor Institute...

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Animal Models of Addiction and the Opioid Crisis

As the opioid crisis continues, every week brings new and alarming developments, legislative attempts to address the epidemic, and new formulations of street drugs which are contaminated, or resistant to naloxone. This has sparked a variety of debates concerning how we can best address the situation. From a public health perspective, however, the need to explore relevant and predictive animal models of addiction and develop novel strategies...

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What Are Germ-Free Mice and How Are They Sourced?

Understanding what germ-free mice are, the opportunities that they offer, and how you can obtain them will help you decide how best to incorporate these models into your research program. The body is inhabited by trillions of microorganisms (the microbiome, consisting of bacteria, fungi, viruses, etc.) which play major roles in health and disease. Axenic or germ-free mice, specially-raised animals devoid of all microorganisms, are increasingly powerful...

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Ali Zahalka Wins AACR 2017 Travel Award

For his work investigating mechanisms connecting SNS-mediated microenvironmental effects to prostate cancer progression, Ali Zahalka was awarded Taconic Biosciences' American Association for Cancer Research (AACR) 2017 Annual Meeting Travel Award. "Our lab is interested in identifying factors that promote early-stage cancer progression," Ali told Taconic, "with the aim of developing novel therapeutic interventions." Taconic's 2017 AACR Travel Grant Winner An MD/PhD candidate in the lab of Dr....

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Rise in Usage of Germ-Free Mice

Germ-free mice are not new. Taconic Biosciences first started raising germ-free mice in 1960, after learning axenic husbandry techniques from the Laboratories of Bacteriology at the University of Notre Dame (LOBUND), where the first germ-free facility was established. Researchers have been using germ-free rodents since the '60s, producing a steady level of publications ...until recently. The use of germ-free animals in research grew dramatically within the last...

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Does the Microbiome Impact Neurological Diseases like Stroke and Seizure?

Cerebral cavernous malformation (CCM) is a type of brain lesion in which normal tissue is displaced by collections of abnormal capillaries which are prone to leakage. CCM bleeding can cause strokes, seizures, and other neurologic deficits. The only current treatment for CCM is surgical removal. What causes this anatomical abnormality? The familial form has been linked to mutations in several genes, and sporadic cases may be linked...

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Yeast Worsens Disease in a Mouse Model of Colitis

Inflammatory bowel disease (IBD) is a disorder of the gastrointestinal tract which includes Crohn's disease and ulcerative colitis. In general, the majority of studies looking at the role of the human gut microbiome have focused on bacterial members. However, fungi are estimated to comprise 0.1% of the intestinal microbiota1, and elevated levels of anti-Saccharomyces cerevisiae antibodies (ASCAs) have been detected in the serum of Crohn's disease patients,...

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Working Towards Microbiome Research Standards

Microbiome research continues at an amazing pace, but labs around the world are racing ahead with few agreed-upon standards. This makes communication difficult and may undermine reproducibility. Growing Call for Microbiome Standards There are groups advocating for common standards, such as The Microbiome Coalition, and the subject frequently comes up at scientific conferences. In 2015, Julian R. Marchesi and Jacques Ravel published a paper suggesting a standard...

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