Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

Novel Humanized Mouse Model Mirrors Patient Responses to Immunotherapy

For the first time, a team of scientists reproduced clinical responses to adoptive T-cell transfer in a rodent model of metastatic melanoma. This could support more accurate preclinical evaluation of novel immunotherapy agents. As described in Nature Communications, University of Gothenburg researchers leveraged the super-immunodeficient CIEA NOG mouse® to establish metastatic melanoma patient-derived xenografts (PDX) for subsequent autologous adoptive cell therapy (ACT). The researchers report tumor eradication...

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Sperm Cryopreservation Overview

Recent improvements in sperm cryopreservation and IVF protocols in mice established sperm cryopreservation as a reliable and efficient method for archiving and distributing genetically engineered mouse lines. Further, the ability to rapidly expand animal model colonies from frozen sperm make sperm cryopreservation a quick and effective method for the distribution and restoration of mouse lines. Sperm cryopreservation is the most common method for cryopreserving mouse lines. Sperm...

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Transferring the Wild Mouse Microbiome via Fecal Microbiota Transfer

An elegant new study proves "natural" microbiomes can be transferred to, and maintained in, SPF laboratory mice. The Problem with SPF Mice Historically, laboratory mice have been valued for their well-defined genetics and a health profile free from mouse pathogens. Over the last thirty years, efforts have been made to improve the health of laboratory mice by removing organisms that are deemed pathogenic. That list is now...

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Introduction to Embryo Cryopreservation

This is the second of a four-part series on the effective use of cryopreservation in maintaining genetically modified mouse and rat lines: Cryopreservation in Colony Management Introduction to Embryo Cryopreservation Sperm Cryopreservation Overview Cryopreservation Decision Tree Embryo Cryopreservation Overview Until recently, cryopreservation of two-cell stage or later stage embryos was the predominant method for preserving lines of laboratory rodent models. The methodology is relatively simple and does...

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Evaluating Vaccines in Humanized Mice

Human Vaccine Evaluation in a Novel Humanized Immune System Mouse The evaluation of specific antibody production requires an in vivo model; however, species differences limit the utility of experimental animals for this purpose. For example, the lack of interspecies homology between the T cell receptor (TCR) repertoire and major histocompatibility complex (MHC) proteins precludes the evaluation of human vaccine responses in rodents. Humanized mice could be the...

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Cryopreservation in Colony Management

Use of genetically engineered rodent models in research requires the lines to be maintained in continuous breeding, which is costly, labor intensive, and takes up limited vivarium space. Also when such colonies are the sole source of the model, there is risk of losing the line altogether to unanticipated death, disease, infertility, genetic drift, or microbial contamination. Effective use of cryopreservation allows researchers to better utilize financial...

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An Orphan no more: GFRAL identified as receptor for weight regulator GDF15

While wild type mice administered GDF15 lose weight, Gfral knockout mice are resistant to the effects of GDF15. Figure from Hsu, J-Y, et al1. Four independent research groups recently identified the previously orphan receptor GFRAL as the receptor for GDF15. The simultaneous publications, one in Nature1 and three in Nature Medicine2,3,4, show that GFRAL expression is restricted to brainstem regions in mice and that GDF15 acts through...

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Book Review: Gnotobiotics

Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities. The book is part of the American College of Laboratory Animal Medicine Series, published by Elselvier, and covers a number of species including rodents, swine and fish. It is assembled from contributions by nineteen authors with firsthand experience managing gnotobiotic facilities. James Fox nicely captures the essence of this book...

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Moderate Exercise Has Limited but Distinguishable Effects on the Mouse Microbiome

Researchers have identified measurable effects of exercise on the gut microbiome in mice, according to a study published in mSystems. In "Moderate Exercise Has Limited but Distinguishable Effects on the Mouse Microbiome," researchers at Dalhousie University, Canada, compared gut microbial diversity and changes in exercise-associated inflammatory markers over an 8-week period in sedentary mice and mice that performed either voluntary or moderate forced exercise. They found levels...

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Seeing the Microbiome with Fresh Eyes

Anthony St. Leger and colleagues from the National Eye Institute at the National Institute of Health (NIH) recently published evidence that the ocular microbiome plays an important immunological role1. The Ocular Microbiome The surface of the human body is colonized by a diverse community of microorganisms, and the eye is no exception. Yet the ocular surface contains relatively few bacteria, approximately 150-fold fewer than the mouth2. Many...

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