Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 65 years through our commitment to anticipating clients’ needs and industry trends. Through our Insights blog, we report on the newest research in the biopharmaceutical industry, provide expert advice regarding the maintenance of murine colonies, as well as comment on R&D and public health news.

Visitors are encouraged to comment and ask questions via the form at the bottom of each Insight.

Raising Heart Health Awareness: American Heart Month

photo from Raising Heart Health Awareness: American Heart Month

February marks American Heart Month — a campaign aimed at educating citizens about the importance of cardiovascular health. The National Heart, Lung, and Blood Institute (NHLBI) is encouraging visitors to their website to adopt heart-healthy behaviors through increasing exercise, as well as positive diet and lifestyle changes. Why Heart Month? Cardiovascular disease is the leading cause of death amongst both men and women in the U.S. each...  Read More

3 Common Flu Shot Myths

photo from 3 Common Flu Shot Myths

For roughly fifty percent of US citizens, getting an annual flu shot is a normal yearly event. However, for the other half of the population, there are numerous reasons why they hesitate before getting one or resist it completely. Below, we list common myths about the flu vaccine and will address the facts for each one of them. According to the Centers for Disease Control (CDC), the...  Read More

Current Liquid Biopsy Landscape

photo from Current Liquid Biopsy Landscape

There are over 1.7 million new cancer diagnoses each year in the US alone1. While recent advances in immuno-oncology and personalized medicine have the potential to decrease cancer deaths, there is still a lack of commonly-used early diagnostic tests to detect the presence of cancer before the patient experiences any physiological symptoms. Liquid Biopsies for Early Detection Research into liquid biopsies as a tool for early cancer...  Read More

Rederivation of Mouse Models at Higher Health Statuses

photo from Rederivation of Mouse Models at Higher Health Statuses

Rederiving murine research models is the process of transferring embryos from one animal into another which is either germ-free or hosts only specifically identified microbiota. This "resets" the health status of the line, allowing the offspring of mice or rats that were previously infected with either viruses, parasites, or bacteria to be used in research studies. This article will review the process of rederiving a mouse line...  Read More

Animal Models in Space Research

photo from Animal Models in Space Research

On Wednesday, December 5th, the Falcon 9 SpaceX rocket launched to the International Space Station (ISS) carrying 5,600 lbs of supplies; a small portion of which were mice of varying ages2. Animal models have been used in space research since the 1940s, and these ongoing projects help us understand how spaceflight affects health in greater depth. This review will highlight the various animal models that have been...  Read More

A Simple Guide to CRISPR

photo from A Simple Guide to CRISPR

In the short time since the introduction of CRISPR technology in 1987, it has proved to be a valuable tool. In 2018, there were over 17,000 publications on CRISPR gene editing technology compared to seven years earlier when there were less than 100 publications. The future is bright in how CRISPR will impact research, treatments, and cures. VOX recently published, A simple guide to CRISPR, one of...  Read More

Effective Communication Improves Quality

photo from Effective Communication Improves Quality

Let's listen in on a hypothetical conversation between a scientist and their procurement department where communication is being used ineffectively: PROCUREMENT OFFICER seated at desk. Enter a SCIENTIST. SCIENTIST: Order me twenty-four B6 mice. Males and Females. Seven weeks of age. PROCUREMENT: (Thinking to themselves) Same scientist, same number of mice from three months ago, I can just replicate the order. (To Scientist) OK. When do you...  Read More

Pros and Cons of Statins

photo from Pros and Cons of Statins

HMG-CoA reductase inhibitors, or Statins, are a class of lipid-lowering medications prescribed to reduce the risk of developing heart disease. First introduced to the market in 1987, statins are one of the most commonly prescribed medications today with around 40 million users in the US alone annually1,2. However, new studies have questioned whether statins are over-prescribed and if they are causing more harm to certain patients than...  Read More

How Are Animal Models Validated?

photo from How Are Animal Models Validated?

Animal models have led to significant leaps in understanding and advancement in human medicine. They are essential for drug discovery and connecting hypothesis-driven benchwork to the patient. However, scientists have struggled with how to define the value of a given animal model1. Animal Model Validation In 1969, McKinney and Bunney were the first to propose criteria on external validity of animal models, mainly focused on affective disorders2....  Read More

'Twas the End of the Year

photo from 'Twas the End of the Year

With apologies to Clement C. Moore 'Twas the end of the year, and in laboratories throughout Scientists were working, to get that last paper out; The final experiments were designed with true care, In the hopes of results and citations so rare. The protocols were written and IACUC form submitted, All resources accounted for, tagged and committed. The technicians in lab coats and experiments underway, Seemed to...  Read More