Taconic Insights

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Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 65 years through our commitment to anticipating clients’ needs and industry trends. Through our Insights blog, we report on the newest research in the biopharmaceutical industry, provide expert advice regarding the maintenance of murine colonies, as well as comment on R&D and public health news.

Modeling Inflammatory Diseases with NOD2 Knockout Mice

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How the Mucosal Barrier Maintains Homeostasis The mucosal barrier lining the digestive tract is not homogenous and consists of three main components1: An intestinal epithelium, physically separating external environment from the deeper tissues of the body, which contains seven cell types, including stem cells required for epithelial renewal, and some immune cells A mucus layer, composed of mucins and antimicrobial peptides, which forms a protective layer over...  Read More

rasH2 Effective for 8-Week Skin Carcinogenicity Studies

photo from <span style='text-transform: lowercase;'>ras</span>H2 Effective for 8-Week Skin Carcinogenicity Studies

rasH2 Supports Short-Term Skin Carcinogenicity Studies A recently published article by Mayumi Kawabe et al. has confirmed the effectiveness of rasH2 in predicting skin carcinogenicity. The most recent article is a follow-up of an earlier paper published in Veterinary Pathology by Kawabe M, Urano K, et al., which concluded that skin promotion effects could be detected within only eight weeks in the rasH2 mice, and that the...  Read More

Controlling Aggression in Mice

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Mice can react to stress, boredom, and even each other by becoming aggressive towards their cagemates, damaging themselves and possibly skewing study endpoints. Here are three solid colony management techniques to try if you need to control aggression in mice: Avoid Introducing New Cagemates Mice are social and establish dominance rankings among themselves. If the mice establish social rankings when they are young, they are less prone...  Read More

Microbe Helps Hosts Exercise Longer

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A recent study published in Nature Medicine reports on the correlation between rigorous exercise and the increase in abundance of a specific bacterial genus in the human gut microbiome. The collaborative group, which includes CRISPR-researcher George Church from Harvard Medical School, established a connection between the abundance of Veillonella atypica and an increased ability to tolerate fitness1. This article adds to the growing evidence that the microbiome...  Read More

Ebola Outbreak: What You Need to Know

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On Wednesday, July 17th, 2019, the World Health Organization (WHO) declared the Ebola outbreak in the Democratic Republic of the Congo (DCR) to be a Public Health Emergency of International Concern. This outbreak was originally declared on August 1, 2018 in Mangina, one of the most populous locations in the country. Since then, the outbreak has been classified as a level 3 emergency, which is the highest-level...  Read More

Video: The Jh mouse permits clinically relevant dosing of immunogenic test articles in syngeneic tumor model systems

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Syngeneic tumor models are important preclinical research tools for immuno-oncology drug discovery. One challenge that researchers may encounter when studying novel therapeutics in syngeneic tumor models is immunogenicity. Biologics can induce an immune response in the host, including the development of anti-drug antibodies (ADA). ADA can prevent determination of efficacy of a biologic drug. One solution to this problem is to perform the syngeneic tumor study in...  Read More

The Next Ten Years of Microbiome Research

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Source: Proctor1 The Human Microbiome Project's former Program Coordinator, Lita Proctor, set out priorities for the next ten years of human microbiome research in a wide-ranging article for Nature1. She also provides reflections on the completed Human Microbiome Project that helped jump-start microbiome research in the US and beyond. In the past ten years microbiome research has consumed more than $1.7B (USD). More than $1B has come...  Read More

The more things change, the more they stay the same: the Amylin liver NASH (AMLN) Diet

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A wide variety of high fat diet-induced non-alcoholic steatohepatitis (NASH) models have been used to recapitulate certain etiological aspects of the disease, with refinements in dietary formulations made over the past decade. Amylin liver NASH model The Amylin liver NASH (AMLN) model was described by Trevaskis et al. in 2012 as a diet-induced model which displayed both aspects of NASH (nonalcoholic steatohepatitis) and metabolic syndrome. The authors...  Read More

Importance of Vitamins in Human and Murine Diets

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Vitamins are organic molecules that are essential for proper metabolism and bodily function. While they go by different names, most vitamins are actually groups of chemically-related organic molecules known as vitamers1. Some vitamins must be obtained from dietary sources as they are produced in insufficient quantities or are not synthesized by the body at all. Humans have thirteen essential vitamins that must be obtained from dietary sources:...  Read More

Webinar Q&A — The Diet Induced NASH B6: A Translational NASH Model for Drug Discovery

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Dr. Janell Richardson recently presented a webinar on the Diet Induced NASH B6, a translational model of NASH for drug discovery. She provided an excellent introduction to the global health problem of nonalcoholic steatohepatitis (NASH), gave an overview of different types of preclinical NASH models and focused in on the Diet Induced NASH B6 as a relevant model of NASH in the context of a metabolic disease...  Read More