Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

Experimental Impacts of Stress and Microbiome

Exposure to stressful situations is difficult to avoid in the life of the laboratory mouse, but study design rarely accounts for the phenotypic effects of stress and the microbiome. Inevitable events and procedures, such as transportation, handling, and restraint, are known to induce stress in mice. Usually the stress response is transient and stabilizes within a period of time. The time until stabilization depends upon many things,...

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Syngeneic Tumor Model Health Standards

The growth in immuno-oncology research, in which the body's own immune system is recruited to fight a tumor, has prompted a shift in preclinical animal models used for oncology research. While traditional cell line xenografts in immunodeficient models are still widely used, they are generally not appropriate for immuno-oncology studies as they lack critical immune cell types required for immunotherapy efficacy. Immuno-oncology researchers have turned to two...

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The Power of Laboratory Mice Infographic

Looking for an accessible primer on the state of laboratory mice in biomedical research? Download Taconic Biosciences' new infographic The Power of Laboratory Mice, or request the infographic as a poster. This laboratory mice infographic can be a helpful reference to those just beginning their work with in vivo research models, as well as to researchers with extensive experience in the lab. It presents information on how...

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Proposed Changes to ICH Carcinogenicity Testing Guidelines — Decision Delayed

While evidence mounts in support of revised carcinogenicity testing guidelines, the number of Carcinogenicity Assessment Documents (CAD) submitted to the ICH S-1 expert working group fell below expected levels. After extending the submission period by two years9, the expert working group (EWG) will meet in June of 2017 to review the conclusions of drug regulatory agencies on the viability of excluding some pharmaceutical agents from the requirement...

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Modeling NK Cells in Immuno-Oncology

What do Rituximab, Trastuzumab, and numerous other cancer immunotherapies have in common? Their anti-tumor efficacy involves the potent tumor-killing activity of natural killer (NK) cells. The induction of antibody-dependent cellular cytotoxicity (ADCC) in NK cells forms the basis for many important ongoing clinical efforts. These efforts are being aided by humanized immune system (HIS) rodent models, which offer an improved in vivo system for translating therapies to...

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Resuscitation Fluid Composition May Improve Sepsis Outcomes

While modern medicine has done little to improve the mortality rates from severe sepsis, modifications in resuscitation fluid composition may prevent disease progression and improve outcomes. Researchers at McMaster University recently demonstrated that altering the concentrations of gluconate and acetate in resuscitation fluid impacts both hepatic cytokine production and leukocyte recruitment in a C57BL/6 mouse model of sepsis. "Resuscitation fluid composition affects hepatic inflammation in a murine...

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It's Time for Lyme Disease

Lyme Disease Bacteria, Borrelia burgdorferi 2 It's easy to get excited about mild weather and the opportunity to relieve cabin fever by enjoying the great outdoors. I was not immune to the urge on February 24, 2017, when we had a record warm temperature of 73°F. I spent the day working in the yard cleaning up the winter debris. After a long day of work, I was...

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Rodent Alzheimer's Disease Model Supports New Therapies

In late 2016 Biogen reported exciting results for aducanumab, their Phase 1 monoclonal antibody therapy for Alzheimer's disease (AD). Patients who received aducanumab showed significant and dose-dependent reduction of brain Amyloid-β (Aβ) and slowing of disease progression. Pre-clinical studies in the APPSWE/Tg2576 mouse model of AD provided the mechanistic clues, dosing insights, and efficacy data that informed the design of Biogen's successful aducanumab Phase I trial. Now,...

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Interested in Learning How the Microbiome Impacts Drug Discovery?

Attend the Translational Microbiome Conference in Boston this April to learn how the microbiome is impacting the drug discovery industry. This industry-leading, three-day conference "focuses on the potential for translational interventions in microbiome research and the challenges the industry will need to address to make this space successful." Taconic Biosciences — the only commercial provider of germ-free mice — will sponsor, speak, and conduct a workshop at...

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Microbiome Research Symposia Review: Microbiome and Disease

Adapted from an image by Nathan Schmidt, University of Louisville Taconic Biosciences recently organized two research symposia on the microbiome and disease, with a focus on translational research. Attendees from across pharma, biotech, and academia convened for two days of presentations and discussions on the cutting edge in microbiome science. Advancing Microbiome Research Symposium: Microbiome & Disease, November 3, 2016, Potomac, MD The first symposium was held...

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