Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 65 years through our commitment to anticipating clients’ needs and industry trends. Through our Insights blog, we report on the newest research in the biopharmaceutical industry, provide expert advice regarding the maintenance of murine colonies, as well as comment on R&D and public health news.

Visitors are encouraged to comment and ask questions via the form at the bottom of each Insight.

Acclimating Rodents to Automated Watering

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If your animal models fail to learn and use their new watering system, dehydration and death may follow. How can you help them adjust? Learning to Use Automated Watering Systems Several rodent suppliers prefer water bottles for their watering systems. The advantage of the water bottle is the sipper tube always has a drop of water on the tip, easily located by young rats and mice. When...  Read More

What You Need to Know About Colorectal Cancer

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March is National Colorectal Cancer Awareness Month. To increase awareness, the Colorectal Cancer Alliance (CC Alliance) has launched a public awareness campaign called "Don't Assume". This organization aims to challenge assumptions about colorectal cancer through online, print, and social media marketing. Unfortunately, this type of cancer is the third most common cancer in the US and the second leading cause of cancer-related deaths1. While previous studies have...  Read More

Summary of colitis mouse models in IBD research

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Inflammatory bowel diseases (IBD) arise from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been utilized to investigate the underlying mechanisms and develop potential therapeutic strategies. Colitis Animal Models In the table below, we summarize commonly used colitis mouse models and provide key features and tips for...  Read More

How Tumor Cells Escape T Cells

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Immunogenic tumor cells often display protein antigens at their surface, which can be recognized by T cells and serve as a signal for T cells to attack the tumor. However, one long-standing paradox is that tumor-specific T cells often co-exist with the tumor cells. If a T cell has already recognized the tumor cells, why can't the T cell kill them at an early stage? How T...  Read More

Studying Hand, Foot, and Mouth Disease with Humanized Mice

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Enterovirus-A71 (EV-A71), a member of the genus Enterovirus in the Picornaviridae family1, is one of the most common causes of hand, foot, and mouth disease (HFMD) in younger children2,3 and occasionally causes large-scale epidemics worldwide, especially within the Asia-Pacific region. In addition, EV-A71 is consistently associated with severe complications of the neurological and pulmonary system that may result in permanent paralysis or even death, especially among younger...  Read More

Depression and the Microbiome

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New research is regularly being published on the connection between the gut microbiome and the central nervous system (CNS) — together known as the gut-brain axis. Alterations in the composition of intestinal microbiota have also been associated with antibiotic use and the progression of infectious diseases. Historically, we have reported on the link between Parkinson's disease and the microbiome, how high salt diets may alter the microbiome,...  Read More

Rpe65 Variants Affect Vision in Animal Models

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Vision researchers are very familiar with several mutations which can affect sight in mice. Chang et al. cataloged 16 separate mutations causing retinal degeneration. Two of the better known mutations are Pde6brd1 (commonly called rd1) and Crb1rd8 (commonly called rd8). The rd1 mutation is present in a number of inbred strains, such as FVB and SJL, and causes blindness by weaning age. The rd8 mutation is present...  Read More

Animal Models and the Question of Adult Neurogenesis

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Adult neurogenesis is the process of generating new neurons after embryonic and postnatal development have concluded. The creation of neural connections later in life has important implications for learning and memory, cognitive decline, and neurobiological diseases such as Alzheimer's. As a result, this topic has garnered a vast amount of attention in contemporary research. Despite such scrutiny, however, both the prevalence and significance of adult neurogenesis in...  Read More

Acclimating Research Animals Through Effective Nurturing

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Welcoming a new cohort of animals into your facility can be very exciting for the research team; this is, unfortunately, very stressful for the animals. Stress induced by transportation, cage changes, initial weigh-ins, and changes in food and watering systems is very common when animals are introduced to a new facility. Stressed animals are more susceptible to secondary illnesses and can have elevated hormone levels for up...  Read More

Webinar review: Patient-Derived Xenografts on Humanized Mice

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Dr. Jens Hoffmann of EPO presented a webinar highlighting new data on preclinical immuno-oncology research using humanized models. The growth in immuno-oncology (IO) research has created a need for more relevant models. The IO field includes many types of drugs, including: genetically engineered immune cells such as CAR-T cells various antibody-based therapies such as antibody-drug conjugates (ADCs) and bi-specific T cell engagers (BITEs) oncolytic viruses and bacteria...  Read More