Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 65 years through our commitment to anticipating clients’ needs and industry trends. Through our Insights blog, we report on the newest research in the biopharmaceutical industry, provide expert advice regarding the maintenance of murine colonies, as well as comment on R&D and public health news.

Ebola Outbreak: What You Need to Know

photo from Ebola Outbreak: What You Need to Know

On Wednesday, July 17th, 2019, the World Health Organization (WHO) declared the Ebola outbreak in the Democratic Republic of the Congo (DCR) to be a Public Health Emergency of International Concern. This outbreak was originally declared on August 1, 2018 in Mangina, one of the most populous locations in the country. Since then, the outbreak has been classified as a level 3 emergency, which is the highest-level...  Read More

Video: The Jh mouse permits clinically relevant dosing of immunogenic test articles in syngeneic tumor model systems

photo from Video: The Jh mouse permits clinically relevant dosing of immunogenic test articles in syngeneic tumor model systems

Syngeneic tumor models are important preclinical research tools for immuno-oncology drug discovery. One challenge that researchers may encounter when studying novel therapeutics in syngeneic tumor models is immunogenicity. Biologics can induce an immune response in the host, including the development of anti-drug antibodies (ADA). ADA can prevent determination of efficacy of a biologic drug. One solution to this problem is to perform the syngeneic tumor study in...  Read More

The Next Ten Years of Microbiome Research

photo from The Next Ten Years of Microbiome Research

Source: Proctor1 The Human Microbiome Project's former Program Coordinator, Lita Proctor, set out priorities for the next ten years of human microbiome research in a wide-ranging article for Nature1. She also provides reflections on the completed Human Microbiome Project that helped jump-start microbiome research in the US and beyond. In the past ten years microbiome research has consumed more than $1.7B (USD). More than $1B has come...  Read More

The more things change, the more they stay the same: the Amylin liver NASH (AMLN) Diet

photo from The more things change, the more they stay the same: the Amylin liver NASH (AMLN) Diet

A wide variety of high fat diet-induced non-alcoholic steatohepatitis (NASH) models have been used to recapitulate certain etiological aspects of the disease, with refinements in dietary formulations made over the past decade. Amylin liver NASH model The Amylin liver NASH (AMLN) model was described by Trevaskis et al. in 2012 as a diet-induced model which displayed both aspects of NASH (nonalcoholic steatohepatitis) and metabolic syndrome. The authors...  Read More

Importance of Vitamins in Human and Murine Diets

photo from Importance of Vitamins in Human and Murine Diets

Vitamins are organic molecules that are essential for proper metabolism and bodily function. While they go by different names, most vitamins are actually groups of chemically-related organic molecules known as vitamers1. Some vitamins must be obtained from dietary sources as they are produced in insufficient quantities or are not synthesized by the body at all. Humans have thirteen essential vitamins that must be obtained from dietary sources:...  Read More

Webinar Q&A — The Diet Induced NASH B6: A Translational NASH Model for Drug Discovery

photo from Webinar Q&A — The Diet Induced NASH B6: A Translational NASH Model for Drug Discovery

Dr. Janell Richardson recently presented a webinar on the Diet Induced NASH B6, a translational model of NASH for drug discovery. She provided an excellent introduction to the global health problem of nonalcoholic steatohepatitis (NASH), gave an overview of different types of preclinical NASH models and focused in on the Diet Induced NASH B6 as a relevant model of NASH in the context of a metabolic disease...  Read More

The Benefits of Environmental Enrichment for Laboratory Mice

photo from The Benefits of Environmental Enrichment for Laboratory Mice

The natural behavior of mice includes burrowing, foraging, exploring, gnawing, and nest building. These behaviors are essential to the well-being of the animal, and if prevented from performing these activities mice may engage in non-productive repetitive behaviors1,2. Prevention from responding to their natural inclinations could result in undue stress for the animal, possibly impacting their health and increasing stress-related hormone levels. Due to their importance in maintaining...  Read More

IBD Severity and Fungi in Microbiome

photo from IBD Severity and Fungi in Microbiome

Source: Limon et al.1 The microbiome includes not just bacteria, but also fungi, viruses and parasites. While most of the attention has been on bacterial components of the microbiome, new research links a commensal yeast found on human skin to disease severity in inflammatory bowel disease (IBD). Linking Common Fungi with IBD Severity In a new paper published in Cell Host & Microbe, Limon et al. examined...  Read More

Modeling Stem Cell Transplantation Treatments for HIV

photo from Modeling Stem Cell Transplantation Treatments for HIV

HIV is a rare, incurable virus that attacks the human immune system. According to the World Health Organization, approximately 36.9 million people are living with HIV or AIDS, and close to 1 million deaths per year are caused by the disease. Currently, there is no vaccine or cure. The standard treatment involves daily, lifelong therapy with multiple antiviral drugs that suppress the virus if taken regularly. Because...  Read More

Adipose Tissue and Hormone Regulation

photo from Adipose Tissue and Hormone Regulation

The incidence of metabolic disease and the number of obese patients in the US is growing at an alarming rate. While the Western diet and lack of exercise may be to blame for some, there are complex biological processes that underlie the progression of obesity in all cases. The Three Kinds of Adipose Tissue Fat, also referred to as adipose tissue, is responsible for the increased storage...  Read More