Taconic Insights

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Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 65 years through our commitment to anticipating clients’ needs and industry trends. Through our Insights blog, we report on the newest research in the biopharmaceutical industry, provide expert advice regarding the maintenance of murine colonies, as well as comment on R&D and public health news.

Knockout Mice for the Study of Coronavirus Infections

photo from Knockout Mice for the Study of Coronavirus Infections

The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2, COVID-19), and its rapid international spread pose a global health emergency. The SARS-CoV-2 virus belongs to the family of coronaviridae viruses, which are enveloped, positive-sense, single-stranded RNA viruses. Entry into human (mammalian) cells depends on binding of the viral spike (S) proteins to human cellular receptors and on S protein priming by host cell proteases. Patients with...  Read More

Taconic Biosciences Learn at Home Series: Oncology

photo from Taconic Biosciences Learn at Home Series: Oncology

With many researchers and laboratory animal professionals under orders to remain at home to limit the spread of coronavirus, we know you may have a bit more time on your hands than usual. To help keep you engaged while working from home, Taconic Biosciences has pulled together a series of educational materials organized around different therapeutic areas. The first track is available now, with additional tracks available...  Read More

Safety Testing Critical for COVID-19 Therapies and Vaccines

photo from Safety Testing Critical for COVID-19 Therapies and Vaccines

"We must urgently develop measures to tackle the new coronavirus -- but safety always comes first." 1Dr. Shibo Jiang As COVID-19 deaths rise and the world economy continues to take devastating hits, countries, states, and cities are desperate for anything that can provide relief. Dr. Jiang, professor of virology at Fudan University, notes that, "combating this disease demands a vaccine that is safe and potent. The fatality...  Read More

Mouse Behavior Impacts the Composition of the Small Intestinal Microbiome and Bile Acid Profile

photo from Mouse Behavior Impacts the Composition of the Small Intestinal Microbiome and Bile Acid Profile

Mice remain the most utilized animal model within microbiome research. The advantages of using mouse models are clear with regard to homogenous genetics, accessibility to germ-free, mutant and/or transgenic models, a comparable physiology and the relatively low cost of performing studies. In addition, the use of mouse models has been key in landmark studies determining the role of the gut microbiota in various diseases. Despite the clear...  Read More

The Complex Role of the Gut Microbiome in Human Wellness and Disease

photo from The Complex Role of the Gut Microbiome in Human Wellness and Disease

Bacteria, Archaea, and Eukarya constitute the most abundant part of the biosphere, including the plants and animals most familiar to most and an invisible world of organisms that many never consider. Although these microbes were known to exist, their diversity and functional significance within our world has not always been fully appreciated. The entire community of microorganisms that inhabit a single environment is known as a microbiome....  Read More

Challenges in Models of Myeloid Cell Engraftment in Humanized Mice

photo from Challenges in Models of Myeloid Cell Engraftment in Humanized Mice

Humanized immune system mice are revolutionary research tools for the development of novel immune cell-targeting oncology therapeutics, but the use of first-generation models such as the huNOG (NOG mice engrafted with human CD34+ hematopoietic stem cells) has been limited for some applications by impaired human myeloid cell differentiation. Several investigators sought to understand the mechanistic bottleneck and identified evolutionary disparities between mouse cytokine growth factors and human...  Read More

Biomedical Research Awareness Day 2020

photo from Biomedical Research Awareness Day 2020

Biomedical Research Awareness Day (BRAD) will be held virtually on April 16th this year due to event postponements from the ongoing COVID-19 pandemic. BRAD is sponsored by Americans for Medical Progress (AMP). This initiative is committed to educating students and the public on the importance of biomedical research and the humane use of animals. The goal is to educate people about the vital role animals play in...  Read More

Which mouse model is best for engrafting human PBMCs?

photo from Which mouse model is best for engrafting human PBMCs?

Humanized immune system mice generated by engrafting immunodeficient hosts with human peripheral blood mononuclear cells (PBMCs) have been critical tools for evaluating T-cell dependent immunotherapies. However, novel immunodeficient hosts are demonstrating their ability to extend the utility of PBMC-humanization beyond conventional T-cell focused work. The hIL-15 NOG mouse carries a transgene expressing human IL-15 and, unlike conventional immunodeficient models, has been shown to facilitate human NK cell...  Read More

Comparison Guide: huNOG-EXL, NSG-SGM3 and MISTRG

photo from Comparison Guide: <span style='text-transform: lowercase;'>hu</span>NOG-EXL, NSG-SGM3 and MISTRG

Several super immunodeficient models expressing cytokines designed to drive myeloid cell lineage commitment have been generated. The most advanced cytokine transgenic mouse models are the huNOG-EXL, NSG-SGM3 and the MISTRG. This group of models has promise to improve human immune system engraftment in mice, but each one has different features which must be considered when choosing an experimental model. Each model expresses two or more human variants...  Read More

An Overview of Mouse Models for COVID-19

photo from An Overview of Mouse Models for COVID-19

COVID-19 is rapidly spreading around the globe and constitutes a global health crisis. This disease is caused by the SARS-CoV-2 virus, a coronavirus related to the SARS-CoV virus which caused the global SARS outbreak in 20031,2. Preclinical research on SARS may provide insight into useful animal models for COVID-19 research, and much of the information presented below is based on studies of SARS. While there is little...  Read More