Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

2017 Microbiome in Mouse Models Workshop Review — Key Topics

Part II: Microbiome Workshop Topics This is the second of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference. Part I: Participants and Presentations Part II: Microbiome Workshop Topics Part III: Best Practices for Study Design In this Insight, we recap workshop topics and discussions relating to the use...

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Parkinson's Disease Model with Endogenous LRRK2 Regulation

No single Parkinson's Disease (PD) model fully reproduces the complexity of the disease in humans. Developing an assortment of PD models has been essential for furthering our understanding of, and the development of potential treatments for, the disease. Adding to the arsenal of PD rodent models, in conjunction with The Michael J. Fox Foundation (MJFF) for Parkinson's Research, a mouse model carrying targeted replacement human LRRK2 G2019S...

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2017 Microbiome in Mouse Models Workshop Review

Part I: Participants and Presentations This is the first of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference. Part I: Participants and Presentations Part II: Microbiome Workshop Topics Part III: Best Practices for Study Design Participating Scientists The microbiome workshop was led by Alexander Maue, PhD, director of...

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HIV Drug Efficacy Affected by Microbiome Composition

The metabolism of pharmacological compounds by our inhabitant microbes can have a significant effect on drug efficacy. While the best-known example may be the inactivation of the drug digoxin by gut flora1, Klatt et al. recently demonstrated that an imbalance in the healthy vaginal microbiome impacts the efficacy of a human immunodeficiency virus (HIV) drug2. Efficacy of Tenofovir Gel Affected by Vaginal Microbiome Composition Tenofovir is a...

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Modeling Malaria with Humanization and Tissue Engineering

The fight against malaria is hampered by the lack of good animal models. The most dangerous malaria parasite, Plasmodium falciparum, has a complex life cycle involving two hosts: mosquitoes and humans. In humans, the parasite has both a liver stage and a red blood cell stage. Because of its host species specificity, P. falciparum has been challenging to model in vivo, particularly during the liver stage. Humanized...

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Researchers Demonstrate Vaccine Mediated Protection Against Zika Virus Using Pregnant Mice

On July 13, 2017, researchers at Washington University School of Medicine published a paper titled, Vaccine Mediated Protection Against Zika Virus Induced Congenital Disease in the journal CELL1. In their study pregnant C57BL/6 mice vaccinated using an mRNA vaccine against the prM-E subunit of the virus and a live attenuated ZIKV-NS1_LAV were challenged with a pathogenic heterologous African ZIKV strain. The mice given a placebo developed high...

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Can Anxiety Phenotypes Transfer via FMT?

Connections between behavioral phenotypes and the microbiome continue to emerge from fecal microbiota transplantation (FMT) studies at McMaster University. Can Behavioral Phenotypes Be Transferred? Researchers at McMaster University first demonstrated the transfer of behavioral traits between mice via the gut microbiome by fecal microbiota transplantation (FMT) in 2011. The authors exploited the observation that two strains of mice, inbred BALB/c and outbred NIH Swiss mice with differing...

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Humanized Mice in Cancer Bone Metastasis Studies

Despite recent advances in cancer research and drug development, bone metastases remain incurable. Some of the most common cancers, such as breast, prostate, lung, and multiple myeloma frequently metastasize to bone1,2,3. As bone metastasis is difficult to treat and target, and because the bone itself is noted to induce drug resistance, the preclinical evaluation of new therapies in more translatable bone metastasis models may increase the likelihood...

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Modified DIO Protocols Improve Type 2 Diabetes Models

Animal models of diet-induced obesity (DIO) are commonly used to model metabolic syndrome, but have some limitations. Can a modified DIO protocol produce better type 2 diabetes models? Developing Modified DIO Protocols DIO C57BL/6 mice are obese, glucose intolerant, insulin resistant, and display mild hyperglycemia. To better model Type 2 diabetes, researchers at the University of Colorado and NYU Langone Medical Center recently developed a modified protocol...

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Murine Lung Microbiome Webinar Recap

On June 8, Dr. Kenneth Klingenberg Barfod — of the National Research Centre for the Working Environment, Denmark — presented a webinar on the importance of the murine lung microbiome, how the lung microbiome in mice can be manipulated experimentally, and its applications in disease modeling. Compared to the extensively studied gut microbiome, the lung microbiome is a niche research area with relatively few published reports. A...

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