Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

Modelling Autophagy in Cellular Processes

Autophagy in Cellular Processes Autophagy is derived from Greek and means self(auto)-eating(phagy). This process occurs in all eukaryotic cell types that contain a lysosomal compartment. In fact, basal autophagy contributes to long-lived protein degradation, organelle turnover in the cytoplasm, and the recycling of macromolecules to maintain bioenergetics1. The purpose of autophagy is not solely the simple elimination of materials, but rather the dynamic recycling of cellular components...

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Bacteria Making Headlines in 2018

In the last few months, multiple bacterial species have been making headlines. This review will outline three types of bacteria and how specific strains may prevent or encourage the development of bacterial infections. I) Escherichia coli (E. coli) The strain that is undoubtedly the most familiar to the general public is E. coli. Once again, romaine lettuce has been abandoned by supermarkets and restaurants as per advice...

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Nobel Awarded to Immuno-Oncology Pioneers

The 2018 Nobel Prize for Medicine was awarded to James P. Allison and Tasuku Honjo for their contributions in the field of Immuno-Oncology. The Immuno-Oncology revolution has improved quality of life and decreased cancer mortality rates, though cancer remains the second leading cause of death worldwide. Immuno-Oncology Databases A variety of models played key roles in the development of cancer therapies, such as xenograft and syngeneic mouse...

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Wash Your Hands

National Handwashing Awareness Week — December 2-8 The week of December 2nd is National Handwashing Awareness week. Moving into winter months and the peak of flu season, spreading awareness of proper handwashing is critical. This is an excellent opportunity to review this and other hygiene practices with animal care staff. The Centers for Disease Control and Prevention (CDC) calls hand washing "a do-it-yourself vaccine." According to the...

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Alzheimer's Disease Awareness Month

As Alzheimer's Disease Awareness Month concludes we review the state of Alzheimer's disease (AD) research, its biological mechanisms, and available in vivo research models of AD. Alzheimer's Disease Overview Since the original National Alzheimer's Disease Awareness Month in November 1983, the number of afflicted patients in the US has risen from two to five million; it is projected to increase to 14 million by 20501. AD is...

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World AIDS Day

World AIDS Day is an annual event held on December 1st. Started in 1988, the purpose of this day is to raise awareness about HIV and AIDS by sharing information concerning prevention, treatment, and control, as well as to honor and mourn the many lives lost to this deadly disease. The focus of this year's 30th Annual World AIDS Day is to find a cure. When World...

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Parkinson's Disease, Your Appendix, and the Microbiome

Parkinson's disease (PD) affects 1 million people in the U.S. annually and there is no known cure. Can connections between the gut microbiome, the appendix, and the pathology of PD provide fresh therapeutic options? State of Parkinson's Disease Treatment Primary treatments and research areas for PD historically revolved around drugs that increase the levels of dopamine in the synaptic space (Levodopa, Lodosyn, Duopa), medications that act as...

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2019 Microbiome Conferences

Looking for a microbiome conference or workshop? Here are some upcoming sessions we'll be following with interest. 2019 Microbiome Conferences: More Specific as Field Matures The Translational Microbiome Research Forum (TMRF) lists thirty-six 2019 conferences so far, and updates their Events page upon announcement of new meetings. While the majority (72%) of microbiome conferences in 2018 were of general interest, 2019 events are much more focused on...

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Seasonal Cycling in the Gut Microbiome of the Hadza Hunter-gatherers of Tanzania

Researchers from Stanford University published a paper in Science titled "Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania" which examines the relationship between diet, seasons, and the microbiome. The authors performed a longitudinal study on 350 stool samples collected throughout a year and a half and found that the microbial population in these samples changed in composition from wet to dry seasons as...

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Nature Biotechnology Publication: Translating microbiome futures

Figure 1: Over the past five years, the scientific output in the microbiome field and the number of microbiome-related published patents has been steadily rising. Sources: PubMed (search terms "human microbiome" and "human microbiota"); Fankhauser et al.; University of Chicago Technology Commercialization; CBInsights; CrunchBase; GlobalData; the companies. The publication of Translating microbiome futures is the culmination of more than a year's work by Gaspar Taroncher-Oldenberg, Consultant in...

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