Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

Guidelines for Use of Humanized Mice in IBD Drug Discovery

Inflammatory Bowel Disease (IBD) is a chronic immunologically mediated disease with no known cure. Can humanized mice speed up IBD drug discovery, bringing relief to the estimated 1.4 million Americans with this difficult condition? To support IBD research, Taconic Biosciences hosted a webinar by TransCure BioServices experts: Chief Executive Officer (CEO), Dr. Patrick Nef, and Chief Scientific Officer (CSO), Dr. Sebastien Tabruyn. TransCure is a contract research...

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Conversion of Immunodeficient Rodent Models to Excluded Flora Health Standard

Taconic Biosciences is converting production of many immunodeficient models from the Restricted Flora™ (RF™) health standards to the Excluded Flora (EF) health profile as part of continuous quality improvements. The next model identified for conversion to Excluded Flora production is the NCr nude, with a target date for conversion by Dec 31, 2016. To ease your transition, free trials are available through the Smart Select program. We...

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Cancer Drug Suggests Promising Alzheimer's Treatment

In a 2015 report, a team of scientist from the Weizmann Institute of Science provided compelling evidence that boosting the immune response in the brain (as opposed to suppressing it) might be a promising avenue for Alzheimer's research. In an extension of its initial findings, the team found that inhibiting an immune-checkpoint pathway which is targeted in the treatment of certain forms of cancer dramatically reduces Alzheimer's...

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C57BL/6 DIO 101: Best Practices for Diet Induced Obesity in Mice

A DIO (diet induced obese) mouse is a C57BL/6 - "Black 6" - mouse which has been made obese through conditioning with a special diet. These diets tend to be high in fat, however there are sometimes other modifications made such as added sugar and there are varying types of fat used to create the diet. View the Taconic Biosciences' Webinar: DIO 101: Diet-induced Obesity in Mice...

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Are Humanized Mice the Future of Oncology Models?

Oncologists are up against the limits of cell cultures and xenografts in applied research. Are humanized mice the solution? In an article discussing the challenge of tumor heterogeneity, Drug Discovery News (DDN) laid out several factors which contribute to heterogeneity and which complicate the clinical presentation of tumors, but which are not well modeled in cell culture: Genetically diverse subclonal populations, both within a tumor and across...

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The Dirty Future of Immunology Animal Models

When discrepancies in immune response arise between animal models and humans, some investigators are quick to question the adequacy of laboratory mice as a proxy for human subjects. Two collaborative studies, published in Nature and Cell Host & Microbe, suggest that animal model microbiome and health standards are key to interpreting these discrepancies - and that mice with more extensive history of pathogen exposure may better model...

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Choosing a Health Standard for Your Model

Taconic Biosciences produces rodent models at several different health standards. How do you know which health designation to choose when ordering animals? Taconic rodent models are available at multiple health standards, enabling researchers to choose the most appropriate model for their studies. The standards can be grouped into barrier standards (with exclusion lists) and gnotobiotic isolator standards (in which all organisms in a location are known). A...

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Preclinical Immuno-Oncology Animal Models

Immuno-oncology - triggering a patient's own immune system to attack their cancer - is sweeping through all levels of oncology research, from academia to biotech and pharma. Silicon Valley mogul Sean Parker, co-founder of Napster and first president of Facebook, pledged $250 million to set up the Parker Institute for Cancer Immunotherapy. Pharma and biotech are betting big on immunotherapy also, with significant resources devoted to immunotherapy...

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Patient-derived Xenografts of Hematological Malignancies Webinar Review

Dr. Julia Schueler of Oncotest presented a webinar exploring her work with patient-derived xenografts (PDX) of hematological malignancies as model systems for drug development and tumor biology research. PDX models of hematological origin provide the same advantages as solid tumor PDX models, such as preserving tumor heterogeneity and the treatment sensitivity profile of the donor patient. View the Taconic Biosciences' Webinar: Patient-Derived Xenografts of Hematological Malignancies For...

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Review: Humanized Mouse Model Research Symposia

Humanized mouse models are critical tools for basic research, modeling of certain human-specific infectious diseases, efficacy testing of immunotherapy approaches, and safety assessment for large molecule therapeutics. Taconic Biosciences recently hosted the symposium series "Advanced Preclinical Models for Immuno-oncology and Infectious Disease" in several European cities, which focused on the latest research applications of human immune system engrafted mice and the introduction of next generation models. International...

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