Taconic Insights

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Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 65 years through our commitment to anticipating clients’ needs and industry trends. Through our Insights blog, we report on the newest research in the biopharmaceutical industry, provide expert advice regarding the maintenance of murine colonies, as well as comment on R&D and public health news.

An update on mouse kidney parvovirus

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The kidneys of immunodeficient mice infected with MKPV appear pale and shrunken on gross necropsy. Histology reveals significant fibrosis. Source: Roediger et al. Cell 20181 It's been over 18 months since mouse kidney parvovirus (MKPV) was identified as a novel pathogen causing inclusion body nephropathy and eventually renal failure and even death in immunodeficient mice. Roediger et al. described this finding in an Oct 2018 Cell paper:...  Read More

Mouse-adapted SARS-CoV-2 strains unlock broader mouse modeling of COVID-19

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COVID-19 modeling in mice has been limited by species differences in the ACE2 protein between mice and humans. The SARS-CoV-2 virus uses the ACE2 protein to facilitate entry into cells. The mouse ACE2 receptor is not permissive for viral binding, and thus initial reports indicate that wild type mice cannot be infected with SARS-CoV-2 1,2. One approach to overcoming this challenge is the use of transgenic mice...  Read More

Transgenic hACE2 mice for SARS-CoV-2 and COVID-19

photo from Transgenic <span style='text-transform: lowercase;'>h</span>ACE2 mice for SARS-C<span style='text-transform: lowercase;'>o</span>V-2 and COVID-19

There is an urgent need to find mouse models to support the development of SARS-CoV-2 vaccines and therapeutics and combat the COVID-19 pandemic. A recent study from Peking Union Medical College has demonstrated the promising application of humanized angiotensin converting enzyme 2 (ACE2) transgenic mice for SARS-CoV-2 research1. Mouse models are widely used to develop and test the safety and efficacy of vaccines and antiviral drugs, as...  Read More

Taconic's Guide to the AACR Virtual Annual Meeting II

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This year the second part of the American Association for Cancer Research's (AACR) Annual Meeting will be held virtually from June 22nd-24th. While the in-person annual AACR conference attracts over 23,000 researchers in multiple fields, the virtual meeting attendance could be even higher with free online access through AACR's website. Topics that will be discussed throughout the meeting include the latest developments in tumor biology and genetics,...  Read More

Webinar Q&A - Beyond HSCs: Humanized Immune System Models Based on PBMCs and Isolated Immune Cell Subsets

photo from Webinar Q&A - Beyond HSCs: Humanized Immune System Models Based on PBMCs and Isolated Immune Cell Subsets

Dr. Paul Volden recently presented a webinar on humanized immune system mouse models, focusing on engraftment of PBMCs and isolated cell subsets. Taconic has extensive experience with humanized mice, both from internal research as well as many collaborations with external partners. Although hematopoietic stem cell-engrafted models such as the huNOG and huNOG-EXL may be better known, these alternate humanization approaches offer advantages for certain studies. We present...  Read More

Taconic Biosciences Learn at Home Series: Inflammatory Bowel Disease (IBD)

photo from Taconic Biosciences Learn at Home Series: Inflammatory Bowel Disease (IBD)

With many researchers and laboratory animal professionals under orders to remain at home to limit the spread of coronavirus, we know you may have a bit more time on your hands than usual. To help keep you engaged while working from home, Taconic Biosciences has pulled together a series of educational materials organized around different therapeutic areas. This is the second track in our series. Learn at...  Read More

Understanding Malocclusion in Research Mice

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The word rodent is derived from the Latin word rodere, which means "to gnaw". This process of gnawing brings to light common dental maladies that are of paramount importance to animal welfare. One specific condition is called malocclusion, which is caused by the misalignment of the incisors and may involve overgrowth of the molars or cheek teeth. If untreated, teeth will overgrow and prevent the rodent from...  Read More

Microbial Metabolism of Bile Acids Contributes to Immunological Balance in the Colon

photo from Microbial Metabolism of Bile Acids Contributes to Immunological Balance in the Colon

Regulatory T (Treg) lymphocytes play an essential role in maintaining homeostasis of the immune system. Characterized by expression of the forkhead box transcription factor (Foxp3), populations of Tregs are divided into two subsets: thymus-derived, or natural Treg cells (nTreg), peripheral Treg cells (pTreg), or induced Treg cells that arise extrathymically1. Both subsets work to maintain immune balance by limiting excessive effector responses and providing immune tolerance to...  Read More

Aged Inbred Mice May Advance Research Into Age-Related Mortality in Coronavirus Infections

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Author note: at the publication date for this Insight, mouse-adapted SARS-CoV-2 viral strains were not available. However, two papers published after this Insight have demonstrated two different approaches for developing these mouse-adapted viral strains. Taconic has published a new Insight discussing this research. Figure Legend: Histopathology of lungs from aged 129S6 (A), B6 (C) and BALB/c (E) mice infected with SARS-CoV at 3 days post-infection. H&E stain....  Read More

2020 Society of Toxicology (SOT) Annual Meeting has Gone Virtual

photo from 2020 Society of Toxicology (SOT) Annual Meeting has Gone Virtual

As with many 2020 scientific meetings and events, the Society of Toxicology (SOT) Annual Meeting was canceled as an in-person event due to the ongoing COVID-19 pandemic. However, SOT has organized a robust offering of online content as a replacement. While nothing beats the energy of a live scientific meeting, the virtual format is available to a broader audience of attendees globally. Visit the 2020 SOT Virtual...  Read More