Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

New Treatments for Type I Diabetes

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While there is no cure for diabetes, new treatment options are achieving notable success improving insulin production via stem cell therapy and cell-identity switching. What is Diabetes? Diabetes mellitus is a group of metabolic disorders in which a patient has higher-than-normal blood sugar levels for prolonged periods. If left untreated, diabetes can cause a plethora of harmful secondary conditions. According to the latest reports from the World...  Read More

Animal Models in Drug Discovery

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The use of animal models in research resulted in the advancement of knowledge for how diseases affect animals and humans. It has also led to the effective treatment of disease symptoms or in many cases disease cures. There are a wide variety of animal models used in drug discovery including, but not limited to Drosophila, C. elegans, mice, rats, rabbits, dogs, cats and non-human primates. Over the...  Read More

The Drug Discovery Process

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Introducing a new drug to market is a complex and time-consuming process that can cost pharmaceutical companies an average $2.6 billion and ten years of research and development. There are multiple defined stages for this process, each with their own associated challenges, timelines, and costs. This review will discuss the entire process, from target discovery through clinical trials and post-approval monitoring for the development of a new...  Read More

Defining the CNS Immune System, One Cell at a Time

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Illustrations of the three general phases of Alzheimer's Disease (AD): #1 Neuron, #2 Neuron with β-amyloid plaques, #3 Neuron with β-amyloid plaques (yellow) and activated microglia (red). In preclinical neuroscience research, the brain's resident immune system and its role in a multitude of CNS diseases have generated a newfound focus on its therapeutic possibilities6. Classically, the CNS has been regarded as having a relatively weak immune surveillance,...  Read More

Acclimating Rodents to Automated Watering

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If your animal models fail to learn and use their new watering system, dehydration and death may follow. How can you help them adjust? Learning to Use Automated Watering Systems Several rodent suppliers prefer water bottles for their watering systems. The advantage of the water bottle is the sipper tube always has a drop of water on the tip, easily located by young rats and mice. When...  Read More

What You Need to Know About Colorectal Cancer

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March is National Colorectal Cancer Awareness Month. To increase awareness, the Colorectal Cancer Alliance (CC Alliance) has launched a public awareness campaign called "Don't Assume". This organization aims to challenge assumptions about colorectal cancer through online, print, and social media marketing. Unfortunately, this type of cancer is the third most common cancer in the US and the second leading cause of cancer-related deaths1. While previous studies have...  Read More

Summary of colitis mouse models in IBD research

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Inflammatory bowel diseases (IBD) arise from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been utilized to investigate the underlying mechanisms and develop potential therapeutic strategies. Colitis Animal Models In the table below, we summarize commonly used colitis mouse models and provide key features and tips for...  Read More

How Tumor Cells Escape T Cells

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Immunogenic tumor cells often display protein antigens at their surface, which can be recognized by T cells and serve as a signal for T cells to attack the tumor. However, one long-standing paradox is that tumor-specific T cells often co-exist with the tumor cells. If a T cell has already recognized the tumor cells, why can't the T cell kill them at an early stage? How T...  Read More

Studying Hand, Foot, and Mouth Disease with Humanized Mice

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Enterovirus-A71 (EV-A71), a member of the genus Enterovirus in the Picornaviridae family1, is one of the most common causes of hand, foot, and mouth disease (HFMD) in younger children2,3 and occasionally causes large-scale epidemics worldwide, especially within the Asia-Pacific region. In addition, EV-A71 is consistently associated with severe complications of the neurological and pulmonary system that may result in permanent paralysis or even death, especially among younger...  Read More

Depression and the Microbiome

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New research is regularly being published on the connection between the gut microbiome and the central nervous system (CNS) — together known as the gut-brain axis. Alterations in the composition of intestinal microbiota have also been associated with antibiotic use and the progression of infectious diseases. Historically, we have reported on the link between Parkinson's disease and the microbiome, how high salt diets may alter the microbiome,...  Read More