Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

Rodent Alzheimer's Disease Model Supports New Therapies

In late 2016 Biogen reported exciting results for aducanumab, their Phase 1 monoclonal antibody therapy for Alzheimer's disease (AD). Patients who received aducanumab showed significant and dose-dependent reduction of brain Amyloid-β (Aβ) and slowing of disease progression. Pre-clinical studies in the APPSWE/Tg2576 mouse model of AD provided the mechanistic clues, dosing insights, and efficacy data that informed the design of Biogen's successful aducanumab Phase I trial. Now,...

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Interested in Learning How the Microbiome Impacts Drug Discovery?

Attend the Translational Microbiome Conference in Boston this April to learn how the microbiome is impacting the drug discovery industry. This industry-leading, three-day conference "focuses on the potential for translational interventions in microbiome research and the challenges the industry will need to address to make this space successful." Taconic Biosciences — the only commercial provider of germ-free mice — will sponsor, speak, and conduct a workshop at...

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Microbiome Research Symposia Review: Microbiome and Disease

Adapted from an image by Nathan Schmidt, University of Louisville Taconic Biosciences recently organized two research symposia on the microbiome and disease, with a focus on translational research. Attendees from across pharma, biotech, and academia convened for two days of presentations and discussions on the cutting edge in microbiome science. Advancing Microbiome Research Symposium: Microbiome & Disease, November 3, 2016, Potomac, MD The first symposium was held...

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Colitis Animal Models in IBD Research Webinar Q&A

Dr. Philip Dubé recently presented a webinar on colitis animal models for IBD research. His presentation introduced three major types of colitis models — chemically-induced, genetically engineered spontaneous colitis models, and adoptive transfer models — with examples of specific models from each type reviewed. Due to time constraints, many of the questions submitted during the webinar went unanswered. We present a full Q&A here. Dextran Sulfate Sodium...

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Are Gnotobiotic Isolators Always Necessary?

Housing system design is fundamentally linked to the stability and characteristics of the mouse microbiome - but are gnotobiotic isolators always necessary to prevent compositional changes in microbiota? A new study published by Randi Lundberg, DVM and co-authors from University of Copenhagen and Technical University of Denmark, characterized the gut microbiota of mice housed in individually ventilated cages (IVCs) and compared it to that of mice housed...

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Oh Transgene, Where Art Thou?
Mapping Transgene Insertion

Over the last three decades, transgenic mice have become a critical in vivo modeling tool in biomedical research. Transgenic technique1, whereby an exogenous gene is inserted into the mouse genome by direct injection of DNA into the pronuclei of a zygote, has enabled thousands of new transgenic lines to be created2. However the technique is not without limitations. One of the biggest drawbacks of using pronuclear injection...

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New Vici Syndrome Mouse Model Could Accelerate Research

Most rare diseases have a genetic component, making access to an animal model with the associated gene mutation a must for developing new therapies. Yet these diseases don't often attract the funding to develop a genetically engineered model of the condition. With the help of Taconic Biosciences, two investigators studying Vici syndrome now have this essential research tool in hand. Vici syndrome is a severe congenital multisystem...

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CRISPR Genome Engineering: Advantages and Limitations

Four years after the debut of CRISPR/Cas9 in mouse genetics, it is time to start drawing some conclusions on its performance, advantages, and limitations as a genome engineering technology1,2,3. Advantages of CRISPR Genome Engineering Arguably, the most important advantages of CRISPR/Cas9 over other genome editing technologies is its simplicity and efficiency. Since it can be applied directly in embryo, CRISPR/Cas9 reduces the time required to modify target...

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Why Your Transgenic Project Failed

Erroneous modification of the mouse genome can lead to the generation of transgenic lines carrying non-functional alleles or unwanted mutations. These faulty models can seriously impact your research program, wasting resources on misleading results. Are Design Errors Driving Translational Failure? Genetically modified mouse models first appeared more than thirty years ago and are still at the heart of biomedical research. The first models carried relatively simple genetic...

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Mouse Model of Alcohol Abuse Shows Microbiome Changes

In one of the few published studies evaluating the role of chronic alcohol exposure and its impact on the microbiome, researchers at University College Cork, National Institute on Alcohol Abuse and Alcoholism, and Teagasc Food Research Centre found marked changes in microbiota in a mouse model of alcohol abuse. After four weeks of exposure to chronic intermittent vaporized ethanol, investigators found a reduction in bacteria alpha diversity...

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