Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

What are Timed Pregnant Rodent Models?

Timed pregnant mice and rats are important research tools, with applications in developmental research, genetic engineering, and generating tissue cultures. They are the most efficient way to obtain a cohort of embryos, fetuses, or pups with a precisely defined, matched age. But what exactly are timed pregnant mice? What Are Timed Pregnant Mice and Rats? A timed pregnant female is a mouse or rat with a precisely...

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Humanized Mice in Safety and Toxicity Testing

Humanized mice are invaluable tools for studying the function of the human immune system in an in vivo context, with applications for studying infectious disease, immuno-oncology, and immunology. Recently, Ryoji Ito and colleagues at the Central Institute for Experimental Animals in Japan demonstrated their efficacy in assessing the safety of chemotherapeutic drug candidates1. Humanized Mice and Myelotoxicity Testing Myelotoxicity is a common treatment-related adverse effect for antineoplastic...

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Diets High in Salt May Increase Sensitivity to Autoimmune Disease through Microbiome Alteration

High salt diets have previously been shown to increase severity of certain types of induced autoimmune disease in mouse models via a signaling pathway, but the impact of these diets on the gut microbiome and intestinal inflammation have not been studied. Researchers at McMaster University recently investigated this question in a paper titled "High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production"...

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2018 Society of Toxicology Annual Meeting — Hot Topics

The annual Society of Toxicology (SOT) meeting is the largest toxicological meeting in the world. The 57th Annual Meeting and ToxExpo was held in San Antonio, Texas, and drew more than 6,100 scientists from Europe, Africa, Asia, Canada, and almost every state of the United States. This is where scientists go to discover all the advances in toxicology from the past year and to meet with colleagues,...

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New Resource for Gnotobiotics Research

Growth in Gnotobiotics Research in gnotobiotic rodents and other animal models is a growing field. The rise in microbiome studies is likely responsible for this increase. This gnotobiotic renaissance has fueled exponential growth in the number of institutions operating or making plans for gnotobiotic facilities and a demand for more education. The non-profit organization, the Association for Gnotobiotics, is answering this need for gnotobiotic knowledge by publishing...

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The Advantages and Limitations of Easi-CRISPR

CRISPR/Cas9 genome editing technology enables the modification of the mouse and rat genomes with unprecedented simplicity and speed but is subject to limitations that restrict its application to the introduction of simple mutations such as constitutive knockout or point mutation alleles. Easi-CRISPR overcomes those limitations by using longer single-stranded DNA, offering researchers a faster and more efficient technology for targeted transgenesis and complex genetic modifications. Limitations of...

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Commensal Microbes May Initiate and Drive Immune Responses in Lupus

Spontaneous lupus erythematosus (SLE) is a chronic autoimmune disease with an unclear cause. Nearly all lupus patients have high levels of anti-nuclear antibodies with a relatively high proportion being pathogenic anti-Ro protein antibodies. At the end of March, researchers at Yale University published a paper entitled "Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus" in the journal Science Translational Medicine in which...

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Video: Mouse Models Used to Study Immuno-oncology

Taconic Biosciences' Dr. Philip Dubé discusses mouse models used to study immuno-oncology in this video excerpt from the webinar, "Advanced Toolkit For Syngeneic Tumor Modeling in Mice". There are essentially two types of models used in pre-clinical immuno-oncology research: Syngeneic models — a mouse tumor is implanted into a genetically identical and immuno-competent host Humanized models — severely immuno-deficient mice are implanted with both a human immune...

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Seminar: Humanized Mice in Preclinical Bone Metastasis Studies

All are welcome to Biocom's continuing education seminar on the use of humanized mice in immuno-oncology and bone metastasis studies on April 12, 2018 at Larkspur Landing. Immuno-Oncology Seminar BioCom will hold an in-person continuing education seminar to explore new study design options in immuno-oncology supported by novel humanized mouse models, including a case study on how one particular humanized mouse could be used to study cancer...

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Taconic's Guide to AACR 2018

This April 22,000 scientists from nearly 100 countries will gather in Chicago for the American Association for Cancer Research 2018 Annual Meeting. Over the course of five days, 6,000 scientists will share results from recent studies, spurring discussion and debate. Attendees can visit 400 exhibitors showcasing new tools and technologies. Presentations at the annual meeting will cover the latest basic, translational, clinical, and prevention-focused research in the...

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