Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

Flu on the Fly

Autumn, when leaves, pumpkin spice, and flu are in the air, is a time to evaluate animal models of influenza pathogenesis and developments in flu research and treatment. This is an introductory reference for influenza studies with a few tips and tricks for utilizing mouse models. Basics of Influenza Influenza has three major subtypes: A, B and C. Type A causes pandemic flu. It is further divided...

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Resources for Improving Quality and Reproducibility in Animal Studies

Quality and reproducibility are the focus of much scientific literature, reviews, and commentaries. Knowledge cannot advance without confidence in the reproducibility of our research. If you work in a laboratory animal facility or use animal models in your research, you know proper training is imperative to quality, reproducibility, and success. Yet, there is no single source of information, regulations, or training materials we can turn to. The...

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Time-restricted Feeding to Prevent Obesity in Juveniles?

There is a growing body of evidence that time-restricted feeding (TRF), for example limiting eating to the active versus inactive phase for a particular species, can impact weight gain and development of obesity. Researchers at the Norwegian University of Science and Technology, the Central Norway Regional Health Authority, and Trondheim University Hospital recently demonstrated that TRF restricts weight gain in juvenile rats. Most previous literature on the...

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Care of Immunodeficient Mice and Rats

Immunodeficient rodents require special husbandry and housing in order to remain healthy and provide optimum experimental performance. Below are recommendations for care and housing of immunodeficient rodents. Upon Delivery of Immunodeficient Rodents Most facilities receive multiple animal deliveries on the same day. These shipments carry rodents of varying strains and health status. Rather than unpacking deliveries randomly, Taconic Biosciences recommends sorting transit cages based on immune status...

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A Redox Link between APOE4 and Alzheimer's Disease Risk?

A Redox Link between APOE4 and Alzheimer's Disease Risk? Individuals homozygous for APOE4, one of three common genetic variants encoding Apolipoprotein E (apoE), carry approximately twelve-times higher risk for an Alzheimer's disease (AD) diagnosis. A recent study suggests a potentially critical link between apoE4 and the antioxidant enzyme Thioredoxin-1 (Trx1) may underlie enhanced AD risk in APOE4 carriers. APOE Alleles Modify Alzheimer's Risk ApoE protein is predominantly...

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Hot Topics at AALAS National Meeting 2017

During the week of October 15, 2017, I attended the 68th National AALAS meeting in Austin, Texas. It has been almost twenty years since I attended my first AALAS National meeting, and it was an excellent opportunity to meet new people and reconnect with colleagues to share lab animal science news. The meeting had ten posters and six platform sessions related to the animal model microbiome. Julia...

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Foundational Gnotobiotics Concepts

Gnotobiology isn't new, but the dramatic expansion of microbiome research has outpaced the development of a common nomenclature within the gnotobiotic research community. Many different, and sometimes confusing, terms are used when referring to different gnotobiotic concepts. To help, here's an overview of the most commonly used gnotobiotic rodent model concepts with examples of how these concepts are applied in basic research and drug discovery. Gnotobiology means...

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Reference DNA from Key Mouse Strains Now Available

Reproducibility Requires Genetic Quality The genetic integrity of laboratory mice and rats is an important contributor to research reproducibility, which is why commercial animal vendors invest in maintaining the genetic quality of standard inbred and outbred strains. As the technology to produce genetically engineered models (GEMs) becomes more widespread, a growing majority of GEMs are bred and used at individual institutions. This decentralization has created concerns regarding...

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Webinar Q&A — Advanced Toolkit for Syngeneic Tumor Modeling in Mice

Did you miss Dr. Philip Dubé's recent webinar, Advanced Toolkit for Syngeneic Tumor Modeling in Mice? His presentation introduced advanced concepts and critical considerations for studying immuno-oncology mechanisms and therapeutics in mice. Webinar Synopsis: Syngeneic models are becoming more advanced due to the availability of genetically engineered mouse models. This advanced toolkit makes it possible to study the many intricate mechanisms through which the immune system controls...

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Microbiome Summit Exploring Industry-Academic Partnerships

International microbiome experts from academia and industry recently came together for the inaugural Microbiome Summit in Copenhagen, Denmark on October 5, 2017. Hosted by the Medicon Valley Alliance (MVA), this summit was intended to "bring together key ... stakeholders from academia, industry and the hospital sector ... to develop knowledge-sharing and a strong scientific community," according to chairman Morten Sommer. Sommer, also a Professor at the Novo...

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