Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

Cystic Fibrosis Treatment from Vertex May Restore Lung Function

Cystic Fibrosis (CF) is a genetic disorder that affects the lungs, digestive system, and a host of metabolic functions. In humans, CF is a progressive disease, where chronic dysfunction of muco-ciliary clearance leads to severe congestion, thick mucus build-up, and severe persistent lung infections. In 1960 the median life expectancy for a patient with CF was ten years old. However, with significant advances in research and clinical...

Read More

Selecting Donors for Fecal Microbiota Transplantation

While fecal microbiota transplantation (FMT) is viewed as a relatively inexpensive and safe method for treating recurring Clostridium difficile infection and other maladies in humans, FMT is not without its challenges, particularly with regard to the screening and selection of fecal donors. In a recent Gut Microbes publication, Woodworth et al. discussed current challenges pertaining to FMT for human use1. The authors evaluate current recommendations for selection...

Read More

A First-Person Account of the Microbiome Revolution

Segmented filamentous bacteria (SFB) in the terminal ileum of an 8-week-old Taconic B6 mouse In a new commentary article in Cell Host & Microbe, Ivaylo Ivanov provides a first-person account of the discovery that microbiota composition affects immune system development and response. Ten years after the first studies showing that development of Th17 cells were regulated by the microbiome, Ivanov details how those discoveries were made. As...

Read More

Probiotics and Animal Health

It's common knowledge that the microbiome is a hot area of biomedical research, with pharma and biotech placing big bets on microbiome therapeutics. But did you know that microbiome research and probiotics are also of interest to the animal health and agriculture markets? Farmers routinely treat livestock with low-dose antibiotics to promote growth, but that practice has been widely criticized as leading to the development of antimicrobial...

Read More

Experimental Impacts of Stress and Microbiome

Exposure to stressful situations is difficult to avoid in the life of the laboratory mouse, but study design rarely accounts for the phenotypic effects of stress and the microbiome. Inevitable events and procedures, such as transportation, handling, and restraint, are known to induce stress in mice. Usually the stress response is transient and stabilizes within a period of time. The time until stabilization depends upon many things,...

Read More

Syngeneic Tumor Model Health Standards

The growth in immuno-oncology research, in which the body's own immune system is recruited to fight a tumor, has prompted a shift in preclinical animal models used for oncology research. While traditional cell line xenografts in immunodeficient models are still widely used, they are generally not appropriate for immuno-oncology studies as they lack critical immune cell types required for immunotherapy efficacy. Immuno-oncology researchers have turned to two...

Read More

The Power of Laboratory Mice Infographic

Looking for an accessible primer on the state of laboratory mice in biomedical research? Download Taconic Biosciences' new infographic The Power of Laboratory Mice, or request the infographic as a poster. This laboratory mice infographic can be a helpful reference to those just beginning their work with in vivo research models, as well as to researchers with extensive experience in the lab. It presents information on how...

Read More

Proposed Changes to ICH Carcinogenicity Testing Guidelines — Decision Delayed

While evidence mounts in support of revised carcinogenicity testing guidelines, the number of Carcinogenicity Assessment Documents (CAD) submitted to the ICH S-1 expert working group fell below expected levels. After extending the submission period by two years9, the expert working group (EWG) will meet in June of 2017 to review the conclusions of drug regulatory agencies on the viability of excluding some pharmaceutical agents from the requirement...

Read More

Modeling NK Cells in Immuno-Oncology

What do Rituximab, Trastuzumab, and numerous other cancer immunotherapies have in common? Their anti-tumor efficacy involves the potent tumor-killing activity of natural killer (NK) cells. The induction of antibody-dependent cellular cytotoxicity (ADCC) in NK cells forms the basis for many important ongoing clinical efforts. These efforts are being aided by humanized immune system (HIS) rodent models, which offer an improved in vivo system for translating therapies to...

Read More

Resuscitation Fluid Composition May Improve Sepsis Outcomes

While modern medicine has done little to improve the mortality rates from severe sepsis, modifications in resuscitation fluid composition may prevent disease progression and improve outcomes. Researchers at McMaster University recently demonstrated that altering the concentrations of gluconate and acetate in resuscitation fluid impacts both hepatic cytokine production and leukocyte recruitment in a C57BL/6 mouse model of sepsis. "Resuscitation fluid composition affects hepatic inflammation in a murine...

Read More