Publications & Media


CASIS Announces Request for Proposals to Access Spaceflight Biospecimens

In association with Taconic Biosciences and BioServe Space Technologies, selected concepts from this Request for Proposals will support Rodent Research Reference Mission-1, a CASIS-sponsored initiative to support biospecimen research onboard the International Space Station U.S. National Laboratory Kennedy Space Center, FL — September 11, 2018 - The Center for the Advancement of Science in Space (CASIS) today announced a Request for Proposals (RFP) for investigators seeking to...

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Humanizing the gut microbiota of mice: Opportunities and challenges

Dr. Randi Lundberg discusses the advantages and drawbacks of research using mice colonized with human fecal microbiota: "Mouse colonized with human fecal microbiota is an interesting model concept with pros and cons like any other model system. The concept provides an ecologically relevant context to study food component and drug metabolism, and is an invaluable tool for phenotype transfer studies to prove the role of the gut...

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Model Systems for Studying the Human Gut Microbiome

Taconic Biosciences' Alexander Maue and Randi Lundberg authored this article in International Pharmaceutical Industry, which "provides an overview of the most popular model system concepts, how they are being employed in gut microbiome research, and how they are complementary to each other:" "A variety of in vivo, in silico, in vitro, and ex vivo model systems are available to researchers for studying the human intestinal microbiome, its...

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Special Report on Drug Delivery: Penetrating the impenetrable

DDNews features Taconic Biosciences' Dr. Megan MacBride who gives remarks on in-vitro models and their limitations: "The 10-year-old boy stares up at the ceiling from his bed, a crooked smile crossing his face. His parents come and go, checking on him periodically to make sure he is OK. They know they won't disturb him; he doesn't really see them. And even when he does, there is little...

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Development of outbred CD1 mouse colonies with distinct standardized gut microbiota profiles for use in complex microbiota targeted studies

The gut microbiota can significantly impact the physiology of the host as well as the interpretation of experimental results in research models. Furthermore, the gut microbiota of mouse models can vary between rodent producers at times making consistency between experimental replicates challenging. To address this issue, investigators from the University of Missouri created colonies of outbred CD1 mice with defined gut microbiota representing commercial providers including Taconic...

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Reclaim the Tumor Microenvironment via "Immunoforming"

Taconic Biosciences' Dr. Paul Volden was interviewed for this article in Genetic Engineering & Biotechnology News regarding tumor microenvironment (TME) research through next-generation humanized models: "Tumorigenesis is to healthy tissue what xenoforming, or hostile terraforming, is to the planet. Both tumorigenesis and xenoforming are processes that alter the environment so that it may become less hospitable to its usual inhabitants, and more welcoming to that which is...

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CRISPR, the Next Generation

Biocompare quotes Taconic Biosciences' Dr. John Couse who details how Easi-CRISPR technology has "brought greater efficiencies, ease, and speed to the generation of a number of model types:" "In just six years, the word CRISPR has gone from meaning a drawer in your refrigerator to the hottest field in biological science. Even people who've never so much as glanced at a copy of Scientific American have probably...

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Rare Genomics Institute Announces Winners Of BeHEARD 2018 Rare Disease Challenge

Diagnostics World News highlights BeHEARD competition winner Marco Giovannini who was awarded a mouse model from Taconic Biosciences which "will allow his lab to test therapy options for schwannomatosis": "The Rare Genomics (RG) Institute has announced the winners of the 2018 BeHEARD (Helping Empower and Accelerate Research Discoveries) science challenge, a global competition that offers rare disease researchers, who traditionally have difficulty attracting funding, grants of the...

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Special Report on Cancer: Aiming for avatars

Dr. Azusa Tanaka of Taconic Biosciences describes the importance of researchers choosing between orthotopic and heterotopic models, that [in the example of a brain tumor] "researchers need to consider how challenging such microsurgeries would be in terms of both technical expertise and time, particularly when the goal is large drug screens:" "The model host is also a significant factor as researchers look to build their PDX models,...

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A direct tissue-grafting approach to increasing endogenous brown fat

In this recent study published in Scientific Reports, researchers at Columbia University used Taconic Biosciences' Diet Induced Obese (DIO) B6 model to study a novel brown adipose tissue engraftment approach for obesity and diabetes: "There is widespread evidence that increasing functional mass of brown adipose tissue (BAT) via browning of white adipose tissue (WAT) could potentially counter obesity and diabetes. However, most current approaches focus on administration...

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