Publications & Media


CRISPR, the Next Generation

Biocompare quotes Taconic Biosciences' Dr. John Couse who details how Easi-CRISPR technology has "brought greater efficiencies, ease, and speed to the generation of a number of model types:" "In just six years, the word CRISPR has gone from meaning a drawer in your refrigerator to the hottest field in biological science. Even people who've never so much as glanced at a copy of Scientific American have probably...

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Special Report on Cancer: Aiming for avatars

Dr. Azusa Tanaka of Taconic Biosciences describes the importance of researchers choosing between orthotopic and heterotopic models, that [in the example of a brain tumor] "researchers need to consider how challenging such microsurgeries would be in terms of both technical expertise and time, particularly when the goal is large drug screens:" "The model host is also a significant factor as researchers look to build their PDX models,...

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Natural born KILLERS - how natural killer cell therapy will transform immunotherapy

Taconic Biosciences' Dr. Azusa Tanaka and Dr. Michael Seiler penned this Drug Discovery World article regarding NK (natural killer) cell therapy and how this will transform immunotherapy: "Regulatory approval of CAR-T cell therapies in 2017 placed the spotlight on immunotherapy approaches that use live cells to attack tumours - a major shift in oncology treatment. Yet even this groundbreaking therapy has limitations, such as when patients already...

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GADD45A and CDKN1A are involved in apoptosis and cell cycle modulatory effects of viscumTT with further inactivation of the STAT3 pathway

In Scientific Reports volume 8, Article number: 5750(2018), S Kelinsimon et al. from Universitätsmedizin, Berlin, Germany analyzed modulatory effects on the cell cycle by viscumTT in three osteosarcoma cell lines in vivo with eight-week-old female CIEA NOG mouse® (NOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac) from Taconic Biosciences. In several pediatric tumor entities, ViscumTT has shown synergistic induction of apoptosis. In this paper, they report reduction of tumor volume and confirmed the...

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GEN Roundup: Animal Models Primed for Evolutionary Burst

Dr. Michael Seiler of Taconic Biosciences discusses animal models that will advance research, drug testing, and clinical studies in this Genetic Engineering & Biotechnology News article: "Dramatic environmental change imposes new challenges. It also creates new opportunities, opening niches and potentially triggering a period of adaptive radiation, a rapid diversification of new forms. Although adaptive radiation is usually understood to be a process that occurs in nature,...

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Taconic Biosciences has new headquarters

Troy Record speaks with Taconic Biosciences CEO Bob Rosenthal about the rationale behind moving their headquarters: "Community leaders welcomed lab animal company Taconic Biosciences to its new local headquarters on Friday at a ribbon cutting ceremony. Founded in 1949, Taconic Biosciences is a breeder and supplier of laboratory animals, producing selectively bred and genetically engineered mice and rats for research use." Read the complete article at: Troyrecord.co...

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Celebrating new headquarters

Times Union reports on Taconic Biosciences' ribbon cutting ceremony for the new Corporate Headquarters: "The Rensselaer County Regional Chamber of Commerce held a ribbon-cutting ceremony on Friday for Taconic Biosciences at its new headquarters office in the Cancer Research Center building at the University at Albany Health Sciences Campus in East Greenbush. Rensselaer County Executive Steve McLaughlin attended the ceremony along with Taconic CEO Robert J. Rosenthal...

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Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice

CIEA's hIL-6 NOG is central in this study which "established a novel humanized transgenic (Tg) mouse strain, human interleukin (hIL)-6-expressing NOG mice (NOG-hIL-6 transgenic mice)." Taconic Biosciences is the only provider of hIL-6 NOG in EU and US: "The tumor microenvironment contains unique immune cells, termed myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs) that suppress host anti-tumor immunity and promote tumor angiogenesis and metastasis. Although these...

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Human immunodeficiency virus Tat impairs mitochondrial fission in neurons

HIV infection is known to cause neurocognitive disorders, with neuronal loss and other abnormalities observed in post-mortem brains of affected individuals. Now a new paper sheds light on the mechanisms of neurotoxicity mediated by the HIV viral protein Tat. Cortical neuronal cultures from embryonic Sprague Dawley® rats sourced from Taconic Biosciences were used as a key model system. The researchers identified that exposure of these rat neuronal...

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Cloned primate paves way for the generation of uniform monkey models, say researchers

Outsourcing Pharma quotes Taconic Biosciences' Michael Seiler, PhD, regarding required factors to establish testable in vivo systems for research: "Biomedical and pharmaceutical stakeholders have heralded the news that Chinese researchers have successfully cloned a monkey and its potential to unlock further our understanding of complex diseases." Read the complete article at: Outsourcing-Pharma.com...

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