Media Coverage

Adapting Your Preclinical Animal Model Strategies for a New World

Adapting Your Preclinical Animal Model Strategies for a New World

In the wake of COVID-19, investigators in the commercial and nonprofit sectors are facing heightened pressure to accelerate drug discovery and speed time to market with efficacious therapies, while maintaining high quality and operating within constrained budgets. In an article in International Biopharmaceutical Industry, Dr. Austin Jelcick of Taconic Biosciences reviews the post-COVID trends reshaping the drug discovery landscape, how research organizations are pivoting, and the model...  Read More

Podcast: Models for Long COVID

Podcast: Models for Long COVID

After recovering from COVID-19 infection, many people experience a diverse range of lingering symptoms that have perplexed both physicians and scientists. In a conversation with Dr. Terina Martinez, Nature writer Vivien Marx explores the underpinnings of long COVID and how mouse models, like those offered by Taconic, are evolving to support studies on this puzzling phenomenon: “...we do know from other viruses that viruses can trigger auto-immune...  Read More

Scientists Set Out to Connect the Dots on Long COVID

Scientists Set Out to Connect the Dots on Long COVID

Millions of people who've been infected by COVID-19 battle lingering and often puzzling symptoms, including fatigue, joint pain, respiratory problems, and "brain fog." A recent article in Nature Methods reviews the complexities of long COVID, how researchers are working to identify its causes, and the role that mouse models are playing in this vital investigatory work. The article provides details on several Taconic COVID-19 models available or...  Read More

Meeting the Need for COVID-19 Models

Meeting the Need for COVID-19 Models

The demand for models to support SARS-CoV-2 research has evolved since the onset of the pandemic, continually shifting as investigators learn more about the mechanisms of the virus. A recent article in Lab Animal reviews how model providers like Taconic Biosciences are responding to the urgent, ever-changing need for mouse models uniquely suited to COVID-19 research. Taconic models discussed in the article include hACE2 lines originally developed...  Read More

With a Myriad of Technologies for Genetically Modifying Models, It Pays to Choose Wisely

With a Myriad of Technologies for Genetically Modifying Models, It Pays to Choose Wisely

Given the diverse portfolio of technologies available to generate genetically engineered models, how do you select the optimal technique for a given research project? In an article in Drug Discovery World, Taconic Biosciences' Dr. Caroline Horizny answers the question by reviewing the different technologies used to genetically modify a model. This comparison of each technique's advantages, disadvantages, and most appropriate applications can aid investigators in making the...  Read More

Cancer Researchers Get a Grip on Immune Cell Plasticity

Cancer Researchers Get a Grip on Immune Cell Plasticity

Certain of the body's immune cells, like macrophages, are particularly good at finding and destroying cancerous cells. But they also have the potential to switch gears and instead promote tumor cell growth. In an interview with Nature Methods, Taconic Biosciences' Dr. Paul Volden discusses the role of humanized immune system mouse models in exploring immune cell plasticity. Dr. Volden also reviews how Taconic's huNOG-EXL mouse is helping...  Read More

The Human Touch: Improving In Vivo Evaluation of Biologics with Humanized Immune System Models

The human Touch: improving <em>In Vivo</em> Evaluation of Biologics with Humanized Immune System Models

The pace of drug discovery for therapeutics based on biological materials is rapidly accelerating. Yet, the same specificity that can make biologics efficacious in humans can limit or eliminate the relevant therapeutic biology in test species, such as mice. In an article in The Journal of Precision Medicine, Taconic Biosciences' Dr. Paul Volden reviews the challenges of preclinical research on biologics, the utility of humanized immune system...  Read More

Animal Models Offer Improved Translatability

Animal Models Offer Improved Translatability

Positive results in preclinical research don't always equate to success in the clinic. To bridge the translation gap, animal model providers are continually enhancing and evolving their model portfolios. In an interview with Genetic Engineering & Biotechnology News, Taconic Biosciences' Dr. Terina Martinez discusses one of the company's newest offerings: a humanized immune system model that alleviates graft vs host disease and possesses mutations that make it...  Read More

As COVID-19 Research Evolves, So Too Will Animal Models

As COVID-19 Research Evolves, So Too Will Animal Models

Even as new vaccines roll out globally, the drug discovery work on COVID-19 is far from over. In an article in Drug Discovery News, Taconic Biosciences' Dr. Terina Martinez explores why infectious disease researchers will need to maintain or accelerate their efforts on both the vaccine and therapeutic fronts. She also discusses how animal models will evolve to support coronavirus research, citing the various types of models...  Read More

Beyond Vaccines

Beyond Vaccines

Rolling out safe, efficacious COVID-19 vaccines worldwide will be a formidable challenge that will take time, causing many more people to become infected in the meantime. In an interview with Drug Discovery News, Taconic Biosciences' Dr. Terina Martinez lent her insights on the need to develop effective COVID-19 therapeutics and the role of mouse models in advancing this important research: “"What we're talking about is finding that...  Read More

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