Media Coverage

A model summer: Preclinical research developments rise with the temperature

A model summer: Preclinical research developments rise with the temperature

Two of Taconic Biosciences's newest products are highlighted in a recent article published in Outsourcing-Pharma. The first, TruBIOME™, is a comprehensive solution to increase reproducibility in mouse models through custom microbial associations. The second is the launch of Taconic's new commercial diet-induced NASH mouse model, which will enable researchers to obtain a model faster for preclinical studies: "As summer heated up, the pharmaceutical industry saw major developments...  Read More

Taconic launches preconditioned NASH mice to accelerate clinical development

Taconic launches preconditioned NASH mice to accelerate clinical development

On July 29, 2019, Taconic Biosciences announced the launch of the first commercially-available diet-induced NASH rodent model. These models will help accelerate clinical development of NASH treatments because they are readily-available off-the-shelf at are varying ages already expressing the symptoms of NASH. These models will save researchers months of planning and accelerate the discovery of novel liver failure treatments: "Aiming to speed up and facilitate the clinical...  Read More

Betting on the Bug: How the Microbiome Can Improve Reproducibility and Translatability

Betting on the Bug: How the Microbiome Can Improve Reproducibility and Translatability

In a recent article published in International Biopharmaceutical Industry, Taconic Biosciences' Dr. Alexander Maue highlights the importance of the mouse gut microbiome and its impact on experimental reproducibility. There is an ongoing reproducibility crisis in the research community, and stabilizing the microbiome of a cohort of mice for multiple generations make take away one contributing factor: "Investigators continually seek to improve the reproducibility of their results and...  Read More

Rodent Research Mission on ISS National Lab Enables Investigators to Leverage Space-Flown Specimens

Rodent Research Mission on ISS National Lab Enables Investigators to Leverage Space-Flown Specimens

On July 27, 2019, 40 female C57BL6/NTac mice were sent to space on SpaceX's 18th commercial resupply to the International Space Station (ISS). 30 of these mice will be returned to Earth for study, while 10 will remain on the ISS laboratory for additional exposure to microgravity. Studies of mice in space have provided key data about muscle and bone physiology, aging, development, and cardiovascular health: "KENNEDY...  Read More

A Proper Welcome: How to Care for Humanized Mice

A Proper Welcome: How to Care for Humanized Mice

Taconic Biosciences' Dr. Megan MacBride penned this article for AALAS to discuss how to properly care for humanized mice such as allowing time to acclimate, limit handling, among other suggestions worth heeding: "When lab mice are received at a research facility, investigators typically are eager to enroll them in a study as soon as possible. That's understandable, given the pressure to speed drug discovery and accelerate time-to-market...  Read More

Farewell, FATZO: a NASH mouse update

Farewell, FATZO: a NASH mouse update

In a recent article published in Lab Animal, Taconic Biosciences' Dr. Megan MacBride comments on the current landscape of commercially-available NASH mouse models. One challenge for developing a model that accurately represents the condition is in the replication of both genetic and environmental effects. While the DIO mouse will not usually exhibit the severe symptoms associated with NASH, multiple model generation companies are working to develop and...  Read More

Comparing Genetic Modification Techniques for Animal Model Generation

Comparing Genetic Modification Techniques for Animal Model Generation

In an article recently published in International Pharmaceutical Industry, Taconic Biosciences' Dr. Caroline Horizny discusses five different methods for genetically modifying mouse and rat models. Each method is different and has both advantages and disadvantages depending on the type of model to be generated. Horizny evaluates random and targeted transgenesis, RNA interference, homologous recombination in embryonic stem (ES) cells, and CRISPR/Cas9 and Easi-CRISPR: "The first germline transmission-capable...  Read More

The Scramble to Find a Model for NASH Before it Becomes an Epidemic

The Scramble to Find a Model for NASH Before it Becomes an Epidemic

Non-alcoholic steatohepatitis, also known as NASH, is a growing concern in the medical community. This disease is characterized by a combination of inflammation and fat accumulation in the liver which can ultimately result in fibrosis, cirrhosis, liver failure, or liver cancer. In a recent article discussing this disease, Taconic Biosciences's Dr. Megan MacBride comments that commercially-available mouse models that develop the symptoms of NASH can have great...  Read More

Cancer and the Microbiome

Cancer and the Microbiome

In an article recently published in The Translational Scientist, Taconic's Dr. Alexander Maue and Dr. Ivan Gladwyn-Ng review the role of the microbiome and development and treatment of cancer. While most early studies involving the microbiome focused on diseases relating to the gastrointestinal tract, researchers are beginning to study how microbiome composition impacts tumor development and whether a given therapeutic is effective. Specifically, the microbiome has been...  Read More

The cure for going alone: How M&A will drive oncology research in 2019

The cure for going alone: How M&A will drive oncology research in 2019

In a recent article published in Drug Discovery World, Taconic Biosciences's Dr. Michael Seiler explains how there have been multiple mergers and acquisitions of key biotech and pharma companies in the last five years. One specific area that has seen major growth is in the field of immunotherapy drugs — drugs that use a patient's immune system to fight cancer. Of note would be the acquisition of...  Read More