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Cancer Researchers Get a Grip on Immune Cell Plasticity

Cancer Researchers Get a Grip on Immune Cell Plasticity

Certain of the body's immune cells, like macrophages, are particularly good at finding and destroying cancerous cells. But they also have the potential to switch gears and instead promote tumor cell growth. In an interview with Nature Methods, Taconic Biosciences' Dr. Paul Volden discusses the role of humanized immune system mouse models in exploring immune cell plasticity. Dr. Volden also reviews how Taconic's huNOG-EXL mouse is helping...  Read More

Animal Models Offer Improved Translatability

Animal Models Offer Improved Translatability

Positive results in preclinical research don't always equate to success in the clinic. To bridge the translation gap, animal model providers are continually enhancing and evolving their model portfolios. In an interview with Genetic Engineering & Biotechnology News, Taconic Biosciences' Dr. Terina Martinez discusses one of the company's newest offerings: a humanized immune system model that alleviates graft vs host disease and possesses mutations that make it...  Read More

As COVID-19 Research Evolves, So Too Will Animal Models

As COVID-19 Research Evolves, So Too Will Animal Models

Even as new vaccines roll out globally, the drug discovery work on COVID-19 is far from over. In an article in Drug Discovery News, Taconic Biosciences' Dr. Terina Martinez explores why infectious disease researchers will need to maintain or accelerate their efforts on both the vaccine and therapeutic fronts. She also discusses how animal models will evolve to support coronavirus research, citing the various types of models...  Read More

Beyond Vaccines

Beyond Vaccines

Rolling out safe, efficacious COVID-19 vaccines worldwide will be a formidable challenge that will take time, causing many more people to become infected in the meantime. In an interview with Drug Discovery News, Taconic Biosciences' Dr. Terina Martinez lent her insights on the need to develop effective COVID-19 therapeutics and the role of mouse models in advancing this important research: “"What we're talking about is finding that...  Read More

Learning More About Animal Models for COVID-19 Research

Learning More About Animal Models for COVID-19 Research

Mouse models are playing an integral role in COVID-19 drug discovery, both for vaccines and targeted therapeutics. In an interview with LAS Pro, Taconic Biosciences' Dr. Megan MacBride shared her insights on the many types of models helping to advance COVID-19 research, including transgenic mice that express human ACE2, mice that transgenically express human HLA variants, and mice that express human ApoE alleles associated with severe COVID-19...  Read More

Colony Management is Key for Aged Neuro Models

Colony Management is Key for Aged Neuro Models

Aged models are vital for studying neurodegenerative diseases that develop later in life, but managing these colonies proves challenging. In an article in Genetic Engineering & Biotechnology News, Taconic Biosciences' Dr. Andrea Leonardi discusses the complexities of managing these colonies, including their susceptibility to attrition and the phenotypes typical of certain neurodegenerative diseases. She also provides strategies for overcoming these obstacles: “To ensure a study is statistically...  Read More

The Model Question: What Are the Benefits of HIS in Drug Discovery?

The Model Question: What Are the Benefits of HIS in Drug Discovery?

Humanized immune system (HIS) models have demonstrated utility in early-stage drug discovery across a range of therapeutic areas. In an interview with Drug Discovery World, Taconic Biosciences' Dr. Paul Volden discusses the types of HIS models, how they've evolved, and the advantages and disadvantages of HIS models that use hematopoietic stem cells (HSCs) vs those that use other cell types. He also explains how HIS models can...  Read More

The COVID-19 Race: how mouse models will help researchers cross the finish line

The COVID-19 Race: how mouse models will help researchers cross the finish line

Research into COVID-19 is rapidly evolving, and Taconic Biosciences' Dr. Megan MacBride explains in a recent article in Drug Discovery World how mouse models will enable researchers to move forward with SARS-CoV-2 research. She also provides examples of several genetically-engineered mouse models that were previously developed to study SARS, a closely-related coronavirus, may be viable candidates for studying COVID-19 viral infection: "The CRISPR/Cas9 system, and variants of...  Read More

Betting on the Bug, Part III: Leveraging the Microbiome to Generate New Models

Betting on the Bug, Part III: Leveraging the Microbiome to Generate New Models

The more investigators learn about the microbiome, the more it becomes clear that it impacts both disease development and treatment. Taconic Biosciences' Dr. Alexander Maue took an in-depth look at the microbiome's role in drug discovery in a three-part series for International Biopharmaceutical Industry. Part 1 explored the microbiome's impact on study reproducibility and translatability. Part 2 reviewed how the microbiome can alter therapeutic effectiveness and clinical...  Read More

Special Report on Neuroscience: On good behavior

Special Report on Neuroscience: On good behavior

In a recent article published in Drug Discovery News, Taconic's Dr. Terina Martinez explains how behavior is influenced by multiple molecular pathways. She goes on to note that studies that aim to explore behavioral observations must be carefully designed and researchers should be very thoughtful in the interpretation of results. As a first step towards advancing neuroscience studies in humans, researchers should first conduct their studies in...  Read More

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