Industry News


The silent microbiome crisis

The Washington Post focuses on the concern of many scientists that "Microbes are disappearing from our bodies," and discusses potential contributing factors: "It is a crisis some scientists believe has similar proportions to climate change, but it gets much less coverage: Microbes are disappearing from our bodies. You may have heard that trillions of microbes -- bacteria, fungi, viruses, protists -- live on every surface of your...

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Enterotypes in the landscape of gut microbial community composition

Microbiome key opinion leaders revisit the concept of enteroptypes in this article in Nature Microbiology. While enterotype classification should not solely be relied upon, the authors argue why enterotypes may still be relevant and useful tools for studying the human microbiome: "Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to...

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Microbiota from Wild Mice Protect Lab Mice from Disease

This article in Alzforum explains how bacteria from wild mice can help laboratory mice from getting diseases: "In the confines of the animal room, lab mice reared for research encounter few microbes. While this safeguards against random infections and improves experimental reproducibility, the artificially sterile environment on its own may have effects on the mice. Now, scientists led by Barbara Rehermann of the National Institute of Diabetes...

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Seres Therapeutics Reports Positive Topline Results from SER-287 Phase 1b Study in Patients with Ulcerative Colitis

Seres Therapeutics reports positive "results from SER-287 phase 1b study in Patients with Ulcerative Colitis": "Seres Therapeutics, Inc., (NASDAQ:MCRB) today announced positive topline results from a SER-287 Phase 1b placebo-controlled induction study in 58 patients with mild-to-moderate Ulcerative Colitis (UC), who were failing current therapies. Study data demonstrate that SER-287, a microbiome therapy containing a consortium of live bacterial spores, resulted in a benefit in clinical remission...

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Beyond CRISPR: A guide to the many other ways to edit a genome

Apart from CRISPR, Nature considers alternative gene-editing tools: "The CRISPR-Cas9 tool enables scientists to alter genomes practically at will. Hailed as dramatically easier, cheaper and more versatile than previous technologies, it has blazed through labs around the world, finding new applications in medicine and basic research. But for all the devotion, CRISPR-Cas9 has its limitations. It is excellent at going to a particular location on the genome...

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What a hunter-gatherer diet does to the body in just three days

CNN discusses how a diverse diet can influence gut health, leading to an improved microbiome in just a few days: "Mounting evidence suggests that the richer and more diverse the community of microbes in your gut the lower your risk of disease. Diet is key to maintaining diversity and was strikingly demonstrated when an undergrad student went on a McDonald's diet for ten days and after just...

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BACE inhibition-dependent repair of Alzheimer's pathophysiology

This PNAS article demonstrates "that BACE inhibition is beneficial to all levels of impairment in an AD mouse model": "Amyloid-β (Aβ) is thought to play an essential pathogenic role in Alzheimer´s disease (AD). A key enzyme involved in the generation of Aβ is the β-secretase BACE, for which powerful inhibitors have been developed and are currently in use in human clinical trials. However, although BACE inhibition can...

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Athletes' Microbiomes Differ from Nonathletes

The Scientist explores the relationship between the microbiome and athleticism: "Genomicist Lauren Petersen has been racing mountain bikes since she was 14 years old. But throughout her teens she battled chronic Lyme disease, suffering recurring bouts of illness that sometimes kept her off her wheels. "I'd feel like crap for a month or two, and then the antibiotics would make me feel like crap, and then I'd...

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Microbial Influence

GenomeWeb details how researchers are experimenting with the microbiome to influence brain development: "Researchers have linked certain brain malformations to the microbiome, the New York Times reports. A team led by the University of Pennsylvania's Mark Kahn reports in Nature that the gut microbiome appears to influence the development of cerebral cavernous malformations. While these malformations — which can lead to stroke and seizures — are due...

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Researchers use gene editing to eliminate HIV infection in mice

CBS News reports that for the first time researchers have successfully eliminated the HIV virus from lab mice, by means of CRISPR gene editing technology: "Have researchers taken a step closer to developing an eventual cure for HIV? A Temple University-led team hopes so, by using a gene editing technique to successfully remove HIV infection from lab mice. The gene-editing tool called CRISPR -- which allows scientists...

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