Taconic Biosciences News

Taconic Biosciences News is your source for current and relevant news on how animal models are being used to drive drug discovery. Use the links below to explore exciting announcements from Taconic via Press Releases, Taconic’s press coverage in Publications and Media, and critical scientific insights within Industry News.

Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice

CIEA's hIL6-NOG is central in this study which "established a novel humanized transgenic (Tg) mouse strain, human interleukin (hIL)-6-expressing NOG mice (NOG-hIL-6 transgenic mice)." Taconic Biosciences is the only provider of hIL-6 NOG in EU and US: "The tumor microenvironment contains unique immune cells, termed myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs) that suppress host anti-tumor immunity and promote tumor angiogenesis and metastasis. Although these cells...

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Human immunodeficiency virus Tat impairs mitochondrial fission in neurons

HIV infection is known to cause neurocognitive disorders, with neuronal loss and other abnormalities observed in post-mortem brains of affected individuals. Now a new paper sheds light on the mechanisms of neurotoxicity mediated by the HIV viral protein Tat. Cortical neuronal cultures from embryonic Sprague Dawley® rats sourced from Taconic Biosciences were used as a key model system. The researchers identified that exposure of these rat neuronal...

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Cloned primate paves way for the generation of uniform monkey models, say researchers

Outsourcing Pharma quotes Taconic Biosciences' Michael Seiler, PhD, regarding required factors to establish testable in vivo systems for research: "Biomedical and pharmaceutical stakeholders have heralded the news that Chinese researchers have successfully cloned a monkey and its potential to unlock further our understanding of complex diseases." Read the complete article at: Outsourcing-Pharma.com...

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Industrial Researcher Prize for Research into Improved Animal Models

"Randi Lundberg has received Innovation Fund Denmark's Industrial Researcher Prize for her research into optimising test mice as model organisms for research into the human intestinal flora:" "Each year Innovation Fund Denmark honours the most talented industrial PhDs or postdocs from the fund's talent programme, who have succeeded in combining a high level of scientific insight with a strong business understanding and have generated commercial results for...

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BeHEARD: rewarding rare disease research

Previous BeHEARD competition winner, Jill Wood, discusses the knockout mouse she won from Taconic Biosciences, which lead to the research of future treatments for Sanfilippo syndrome: "In October 2017, the Rare Genomics Institute (RG) announced the launch of the 2018 BeHEARD (Helping Empower and Accelerate Research Discoveries) science challenge. The competition, which has been hosted annually since 2012, aims to advance rare disease research via cash and...

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NK Cell Therapy Advances, Enabled by Precision Models

Taconic Biosciences' Dr. Azusa Tanaka penned this article in Genetic Engineering & Biotechnology News about advancing In Vivo NK Cell studies by utilizing Precision Research Models: "As the field of immunotherapy progresses, and more effective treatments reach patients, the use of live cells to attack tumors has become the next area of focus. While checkpoint inhibitors such as anti PD-1, PD-L1, and CTLA-4 have demonstrated they are...

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Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

4E-BP1 downregulation has previously been linked to cancer progression. Now in a new paper in Nature, the mechanism for 4E-BP1 expression loss has been linked to the Snail transcription factor. In vivo studies using NCr nude mice sourced from Taconic Biosciences demonstrated that inhibition of Snail activity may be a new strategy to improve efficacy of mTor-targeted chemotherapies: "Loss of 4E-BP1 expression has been linked to cancer...

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A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma

An article in Scientific Reports describes a new Hepatoblastoma mouse model, generated using patient samples and Taconic Biosciences' NOG mice: "Currently, preclinical testing of therapies for hepatoblastoma (HB) is limited to subcutaneous and intrasplenic xenograft models that do not recapitulate the hepatic tumors seen in patients. We hypothesized that injection of HB cell lines into the livers of mice would result in liver tumors that resemble their...

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Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer

BALB/c mice sourced from Taconic Biosciences contribute to advances in the treatment of epithelial ovarian cancers. Epithelial ovarian cancers are the seventh most common types of cancer in women worldwide, comprising an estimated 240,000 new cases per year and resulting in a 5-year overall survival rate that ranges from 30 to 50%. The development of novel agents with increased antitumor efficacy and limited toxicity is, thus, a...

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Enterotypes in the landscape of gut microbial community composition

Microbiome key opinion leaders revisit the concept of enteroptypes in this article in Nature Microbiology. While enterotype classification should not solely be relied upon, the authors argue why enterotypes may still be relevant and useful tools for studying the human microbiome: "Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to...

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