Taconic Biosciences News

Taconic Biosciences News is your source for current and relevant news on how animal models are being used to drive drug discovery. Use the links below to explore exciting announcements from Taconic via Press Releases, Taconic’s press coverage in Publications and Media, and critical scientific insights within Industry News.

Expediting the Creation of Mouse Models

Dr. Kenneth Albrecht penned this article in Genetic Engineering & Biotechnology News, specifically about expediting the creation of mouse models: "Pressure to accelerate drug discovery is high, and can be impacted by how mouse models are generated and bred. This tutorial reviews the use of two techniques that, when combined, reduce the time needed to reach the experimental cohort stage when CRISPR/Cas9-mediated gene editing in embryos is...

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Lab mice's ancestral 'Eve' gets her genome sequenced

Nature interviews Taconic's Ana Perez about Taconic's efforts to account for genetic drift, and that Taconic plans to publish the genome of its own 'Eve': "Adam and Eve, a pair of black mice, lived for less than two years and never left their home at the Jackson Laboratory (JAX) in Bar Harbor, Maine. But since they were bred in 2005, their progeny have spread around the globe:...

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Taconic Biosciences Launches New Tagline, Celebrating Commitment to Customers and the Microbiome

Hudson, NY — October 6, 2017 - Taconic Biosciences, a global leader in genetically engineered rodent models and associated services, announces the launch of a new tagline: "Models For Life™." Introducing a fresh interpretation of Taconic's brand and 65 year history, the new tagline celebrates Taconic's unparalleled commitment to its customers and industry leading microbiome products and services. The new 'Models For Life' tagline sits at the...

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Seres Therapeutics Reports Positive Topline Results from SER-287 Phase 1b Study in Patients with Ulcerative Colitis

Seres Therapeutics reports positive "results from SER-287 phase 1b study in Patients with Ulcerative Colitis": "Seres Therapeutics, Inc., (NASDAQ:MCRB) today announced positive topline results from a SER-287 Phase 1b placebo-controlled induction study in 58 patients with mild-to-moderate Ulcerative Colitis (UC), who were failing current therapies. Study data demonstrate that SER-287, a microbiome therapy containing a consortium of live bacterial spores, resulted in a benefit in clinical remission...

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Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy

In this article from Oncogene, research was conducted on C57BL/6 mice sourced from Taconic Biosciences: "Toll-like receptor 5 (TLR5) is considered an attractive target for anticancer immunotherapy. TLR5 agonists, bacterial flagellin and engineered flagellin derivatives, have been shown to have potent antitumor and metastasis-suppressive effects in multiple animal models and to be safe in both animals and humans. Anticancer efficacy of TLR5 agonists stems from TLR5-dependent activation...

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Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm

C57BL/6 male mice sourced from Taconic Biosciences were used for research in this article from Nature Communications: "In vivo fluorescence imaging in the near-infrared region between 1500-1700 nm (NIR-IIb window) affords high spatial resolution, deep-tissue penetration, and diminished auto-fluorescence due to the suppressed scattering of long-wavelength photons and large fluorophore Stokes shifts. However, very few NIR-IIb fluorescent probes exist currently. Here, we report the synthesis of a...

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Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model

This article in Nature Communications features NOG and hIL2-NOG mice derived from Taconic Biosciences: "Immune checkpoint inhibitors and adoptive cell transfer (ACT) of autologous tumor-infiltrating T cells have shown durable responses in patients with melanoma. To study ACT and immunotherapies in a humanized model, we have developed PDXv2.0 -- a melanoma PDX model where tumor cells and tumor-infiltrating T cells from the same patient are transplanted sequentially...

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Obesity: Receptors identified for a weight regulator

Gfral knockout mice from Taconic Biosciences played a pivotal role in studies highlighted in Nature: "The discovery of the receptors for the protein GDF15 suggests that it regulates food uptake through the emergency pathway — a neuronal circuit that causes weight loss in response to cancer, tissue damage and stress." Read* the article at: Nature.com*Registration required to view complete article...

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Relevante Mausmodelle schneller und effektiv züchten

Transkript discusses how Taconic Biosciences' ExpressMODEL™ service can generate new animal models in less time than traditional approaches: "Die genetische Modifizierung von Mäusen legt die Grundlage dafür, dass sich mithilfe dieser Tiere gewonnene Forschungsergebnisse besser auf den Menschen übertragen lassen. Zur Herstellung von gentechnisch veränderten Mausmodellen gehört die präzise Veränderung des Genoms und die Züchtung einer für präklinische Studien relevanten Anzahl an Versuchstieren. Die Zeitspanne zur Erstellung...

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An optical probe for detecting chondrocyte apoptosis in response to mechanical injury

A study in Scientific Reports features the use of Taconic Biosciences' BALB/c mice in examining chondrocyte apoptosis: "Cartilage injury induced by acute excessive contact stress is common and mostly affects young adult. Although early detection of cartilage injury may prevent serious and lifelong arthritic complications, early detection and treatment is not possible due to the lack of a reliable detection method. Since chondrocyte injury and subsequent cell...

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