UPCOMING WEBINAR:

Making Use of Cryopreserved Mouse Repositories

Thursday, April 20 at 11 a.m. ET

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Taconic White Paper:

Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • Proposed Changes to ICH Carcinogenicity Testing Guidelines — Decision Delayed

    While evidence mounts in support of revised carcinogenicity testing guidelines, the number of Carcinogenicity Assessment Documents (CAD) submitted to the ICH S-1 expert working group fell below expected levels. After extending the submission period by two years9, the expert working group (EWG) will meet in... Read more

  • Modeling NK Cells in Immuno-Oncology

    What do Rituximab, Trastuzumab, and numerous other cancer immunotherapies have in common? Their anti-tumor efficacy involves the potent tumor-killing activity of natural killer (NK) cells. The induction of antibody-dependent cellular cytotoxicity (ADCC) in NK cells forms the basis for many important ongoing clinical efforts. These... Read more

  • Resuscitation Fluid Composition May Improve Sepsis Outcomes

    While modern medicine has done little to improve the mortality rates from severe sepsis, modifications in resuscitation fluid composition may prevent disease progression and improve outcomes. Researchers at McMaster University recently demonstrated that altering the concentrations of gluconate and acetate in resuscitation fluid impacts both... Read more

  • It's Time for Lyme Disease

    Lyme Disease Bacteria, Borrelia burgdorferi 2 It's easy to get excited about mild weather and the opportunity to relieve cabin fever by enjoying the great outdoors. I was not immune to the urge on February 24, 2017, when we had a record warm temperature of... Read more

  • Rodent Alzheimer's Disease Model Supports New Therapies

    In late 2016 Biogen reported exciting results for aducanumab, their Phase 1 monoclonal antibody therapy for Alzheimer's disease (AD). Patients who received aducanumab showed significant and dose-dependent reduction of brain Amyloid-β (Aβ) and slowing of disease progression. Pre-clinical studies in the APPSWE/Tg2576 mouse model of... Read more

  • Interested in Learning How the Microbiome Impacts Drug Discovery?

    Attend the Translational Microbiome Conference in Boston this April to learn how the microbiome is impacting the drug discovery industry. This industry-leading, three-day conference "focuses on the potential for translational interventions in microbiome research and the challenges the industry will need to address to make... Read more

  • Microbiome Research Symposia Review: Microbiome and Disease

    Adapted from an image by Nathan Schmidt, University of Louisville Taconic Biosciences recently organized two research symposia on the microbiome and disease, with a focus on translational research. Attendees from across pharma, biotech, and academia convened for two days of presentations and discussions on the... Read more

  • Colitis Animal Models in IBD Research Webinar Q&A

    Dr. Philip Dubé recently presented a webinar on colitis animal models for IBD research. His presentation introduced three major types of colitis models — chemically-induced, genetically engineered spontaneous colitis models, and adoptive transfer models — with examples of specific models from each type reviewed. Due... Read more