Conditional Knock Out with Cre-ER Gene Switch

Conditional Knock Out with Cre-ER Gene Switch eliminates gene function in an inducible manner using our proprietary Cre-ER technology. This technology allows examination of gene function at the desired age or stage of development in the mouse

Generation of Mouse Models with targeted transgene into the ROSA26 locus consists of the following major steps:

1. Targeting Vector Design & Construction
2. Targeted C57BL/6 ES cells
3. Generation of mice heterozygous for the Cre-ER gene switch conditional knock out

Expected timeline: 40 WEEKS

Taconic has incorporated rigorous quality control and documentation of different mouse production steps using project management software and the Laboratory Information Management System (LIMS). A designated Taconic scientific project manager will ensure optimal communication and strict adherence to the timeline and deliverables throughout the project. Taconic will provide a detailed Milestone Documentation after each of the steps mentioned above.

Upon generation of the line at Taconic, we will coordinate the delivery and further breeding of your animals to produce the research cohorts you want at the health status you need.

Learn more about our Cohort Production Packages for Conditional Knock Out with Cre-ER Gene switch.