Hematopoietic stem cell engraftment (humanized mice)
Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, Ueyama Y, Koyanagi Y, Zugamura K, Tsuji K, Heike T, Nakahata T. (2002) NOD/SCID/γc null mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100(9):3175-3182.
Saito Y, Kametani Y, Hozumi K, Mochida N, Ando K, Ito M, Nomura T, Tokuda Y, Mukuuchi H, Tajima T, Habu S. (2002) The in vivo development of human T cells from CD34+ cells in the murine thymic environment. Int Immunol 14(10):1113-1124.
Hiramatsu H, Nishikomoro R, Heike T, Ito M, Kobayshi K, Katamura K, Nakahata T. (2003) Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/γc null mice model. Blood 102:873-880.
Yahata T, Ando K, Nakamura Y, Uevama Y, Shimamura K, Tamaoki N, Kato S, Hotta T. (2002) Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/shi-scid, IL-2 receptor gamma null mice. J Immunol 169:204-209.
Matsumura T, Kametani Y, Ando K, Hirano Y, Katano I, Ito R, Shiina M, Tsukamoto H, Saito Y, Tokuda Y, Kato S, Ito M, Motoyoshi K, Habu S. (2003) Functional CD5+ B cells develop predominantly in the spleen of NOD/SCID/γc null (NOG) mice transplanted either with human umbilical cord blood, bone marrow and mobilized peripheral blood CD34+ cells. Exp Hematol 31:789-797.
Yahata T, Ando K, Miyatake H, Uno T, Sato T, Ito M, Kato S, Hotta T. (2004) Competitive repopulation assay of two gene-marked cord blood units in NOD/SCID/γc null mice. Molecular Therapy 10(5):882-91.
Kambe N, Hiramatsu H, Shimonaka M, Fujino H, Nishikomori R, Heike T, Ito M, Kobayashi K, Ueyama Y, Matsuyoshi N, Miyachi Y, Nakahata T. (2004) Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body. Blood 103(3):860-867.
Nakata H, Maeda K, Miyakawa T, Shibuyama S, Matsuo M, Takaoka Y, Ito M, Koyanagi Y, Mitsuya H. (2005) Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor. J Virol 79(4):2087-2096.
Kai M, Hagiwara T, Emuta C, Chisaka Y, Tsuruhata K, Endo C, Inagaki Y, Miyazaki H, Kataoka S. (2009) In vivo efficacy of anti-MPL agonist antibody in promoting primary human hematopoietic cells. Blood 113(10):2213-6.
Kametani Y, Shiina M, Katano I, Ito R, Ando K, Toyama K, Tsukamoto H, Matsumura T, Saito Y, Ishikawa D, Taki T, Ito M, Imai K, Tokuda Y, Kato S, Tamaoki N, Habu S. (2006) Development of human-human hybridoma from anti-Her-2peptide-producing B cells in immunized NOG mouse. Exp Hematol 34:1239-1247.
Yahata T, Yumino S, Seng Y, Miyatake H, Uno T, Muguruma Y, Ito M,Miyoshi H, Kato S, Hotta T, Ando K. (2006) Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells. Blood 108:2446-2454.
Muguruma Y, Yahata T, Miyatake H, Sato T, Uno T, Itoh J, Kato S, Ito M, Hotta T, Ando K. (2006) Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment. Blood 107:1878-1887.
Watanabe S, Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y,Dewan MZ, Yu Z, Ito M, Morio T, Shimizu N, Honda M, Yamamoto N. (2007) Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses. Blood 109:212-218.
Watanabe S, Ohta S, Yajima M, Terashima K, M.Ito, H.Mugishima H, Fujiwara S, Shimizu K, Honda M, Shimizu N, Yamamoto .N (2007) Humanized NOD/SCID/IL2Rgamma(null) mice transplanted with hematopoietic stem cells under nonmyeloablative conditions show prolonged life spans and allow detailed analysis of human immunodeficiency virus type 1 pathogenesis. J Virol 81(23):13259-13264.
Fujino H, Hiramatsu H, Tsuchiya A, Niwa A, Noma H, Shiota M, Umeda K, Yoshimoto M, Ito M, Heike T, Nakahata T. (2007) Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gamma(c)null mice through cell fusion. FASEB J 21:3499-3510.
Nomura T, Tamaoki N, Takakura A, Suemizu H. (2008) Basic concept of development and practical application of animal models for human diseases. Curr Top Microbiol Immunol 324:1-24.
Ito M, Kobayashi K, Nakahata T. (2008) NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models. Curr Top Microbiol Immunol 324:53-76.
Ito R, Shiina M, Saito Y, Tokuda Y, Kametani Y, Habu S. (2008) Antigen-specific antibody production of human B cells in NOG mice reconstituted with the human immune system. Curr Top Microbiol Immunol 324:95-107.
Koyanagi Y, Tanaka Y, Ito M, Yamamoto N. (2008) Humanized mice for human retrovirus infection. Curr Top Microbiol Immunol 324:133-48.
Yamane A, Nakamura T, Suzuki H, Ito M, Ohnishi Y, Ikeda Y, Miyakawa Y. (2008) Interferon-alpha 2b-induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes. Blood 112(3):542-50.
Nogami W, Yoshida H, Koizumi K, Yamada H, Abe K, Arimura A, Yamane N, Takahashi K, Yamane A, Oda A, Tanaka Y, Takemoto H, Ohnishi Y, Ikeda Y, Miyakawa Y. (2008) The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica 93(10):1495-504.
Shima H, Takubo K, Iwasaki H, Yoshihara H, Gomei Y, Hosokawa K, Arai F, Takahashi T, Suda T. (2009) Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice. Biochem Biophys Res Commun 378(3):467-72.
Kawaguchi AT, Kametani Y, Kato S, Furuya H, Tamaoki K, Habu S. (2009) Effects of liposome-encapsulated hemoglobin on human immune system: evaluation in immunodeficient mice reconstituted with human cord blood stem cells. Artif Organs 33(2):169-76.
Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, Tsuchiya S, Sugamura K. (2009) The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice). Int Immunol 21(7):843-58.
Sato K, Nie C, Misawa N, Tanaka Y, Ito M, Koyanagi Y. (2010) Dynamics of memory and naive CD8+ T lymphocytes in humanized NOD/SCID/IL-2Rgammanull mice infected with CCR5-tropic HIV-1. Vaccine 28 Suppl 2:B32-37.
Zhang L, Meissner E, Chen J, Su L. (2010) Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis. Sci China Life Sci 53(2):195-203.
Wakui M, Suemizu H. (2010) [Development of humanized models using NOG mice]. Seikagaku 82(4):314-8. [Article in Japanese]
Hirosawa T, Torikai H, Yanagisawa M, Kamei M, Imahashi N, Demachi-Okamura A, Tanimoto M, Shiraishi K, Ito M, Miyamura K, Shibata K, Kikkawa F, Morishima Y, Takahashi T, Emi N, Kuzushima K, Akatsuka Y. (2011) Mismatched human leukocyte antigen class II-restricted CD8(+) cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation. Cancer Sci 102(7):1281-6.
Dewan Z, Terashima K, Taruishi M, Hasegawa H, Ito M, Tanaka Y, Mori N, Sata T, Koyanagi Y, Maeda M, Kubuki Y, Okayama A, Fujii M, Yamamoto N. (2003) Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/γc null mice: suppression by an inhibitor against NF-κB. J Virol 77(9):5286-5294.
Dewan MZ, Terunuma H, Ahmed S, Ohba K, Takada M, Tanaka Y, Toi M,Yamamoto N. (2005) Natural killer cells in breast cancer cell growth and metastasis in SCID mice. Biomed Pharmacother 59 Suppl 2:S375-379.
Dewan MZ, Terunuma H, Toi M, Tanaka Y, Katano H, Deng X, Abe H, Nakasone T, Mori N, Sata T, Yamamoto N. (2006) Potential role of natural killer cells in controlling growth and infiltration of AIDS-associated primary effusion lymphoma cells. Cancer Sci 97:1381-1387.
Terunuma H, Deng X, Dewan Z, Fujimoto S, Yamamoto N. (2008) Potential role of NK cells in the induction of immune responses: implications for NK cell-based immunotherapy for cancers and viral infections. Int Rev Immunol 27:93-110.
Shiokawa M, Takahashi T, Murakami A, Kita S, Ito M, Sugamura K, Ishii N. (2010) in vivo assay of human NK-dependent ADCC using NOD/SCID/gammac(null) (NOG) mice. Biochem Biophys Res Commun 399:733-737.
Antibody-dependent-cellular cytotoxicity (ADCC)
Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F, Takino H, Mori F, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model. Cancer Immunol Immunother 58(8):1195-206.
Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H, Inagaki A, Suzuki S, Takino H, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo. J Immunol 183(7):4782-91.
Shiokawa M, Takahashi T, Murakami A, Kita S, Ito M, Sugamura K, Ishii N. (2010) in vivo assay of human NK-dependent ADCC using NOD/SCID/gammac(null) (NOG) mice. Biochem Biophys Res Commun 399:733-737.
Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, Tsuchiya S, Sugamura K. (2009) The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice). Int Immunol 21(7):843-58.
Inoue M, Senju S, Hirata S, Irie A, Baba H, Nishimura Y. (2009) An in vivo model of priming of antigen-specific human CTL by Mo-DC in NOD/Shi-scid IL2rgamma(null) (NOG) mice. Immunol Lett 126(1-2):67-72.
Sato K, Nie C, Misawa N, Tanaka Y, Ito M, Koyanagi Y. (2010) Dynamics of memory and naive CD8+ T lymphocytes in humanized NOD/SCID/IL-2Rgammanull mice infected with CCR5-tropic HIV-1. Vaccine 28 Suppl 2:B32-37.
Katano I, Ito R, Eto T, Aiso S, Ito M. (2011) 14. Immunodeficient
Oh JY, Kim MK, Ko JH, Lee HJ, Kim Y, Park CS, Park CG, Kim SJ, Wee WR, Lee JH. (2009) Acute cell-mediated rejection in orthotopic pig-to-mouse corneal xenotransplantation. Xenotransplantation 16(2):74-82.
Ito R, Katano I, Kawai K, Hirata H, Ogura T, Kamisako T, Eto T, Ito M. (2009) Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice. Transplantation 15;87(11):1654-8.
Hirosawa T, Torikai H, Yanagisawa M, Kamei M, Imahashi N, Demachi-Okamura A, Tanimoto M, Shiraishi K, Ito M, Miyamura K, Shibata K, Kikkawa F, Morishima Y, Takahashi T, Emi N, Kuzushima K, Akatsuka Y. (2011) Mismatched human leukocyte antigen class II-restricted CD8(+) cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation. Cancer Sci 102(7):1281-6.
Dewan M Z, Terashima K, Ahmed S, Ohba K, Taruishi M, Yamamoto N. (2005) Mouse serum factor(s) down-modulate the CD4 and CXCR4 molecules on human T cells conferring resistance to HIV infection in NOG mice. Med Microbiol Immunol 194:175-180.
Nakata H, Maeda K, Miyakawa T, Shibuyama S, Matsuo M, Takaoka Y, Ito M, Koyanagi Y, Mitsuya H. (2005) Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor. J Virol 79(4):2087-2096.
Watanabe S, Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y,Dewan MZ, Yu Z, Ito M, Morio T, Shimizu N, Honda M, Yamamoto N. (2007) Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses. Blood 109:212-218.
Watanabe S, Ohta S, Yajima M, Terashima K, M.Ito, H.Mugishima H, Fujiwara S, Shimizu K, Honda M, Shimizu N, Yamamoto N. (2007) Humanized NOD/SCID/IL2Rgamma(null) mice transplanted with hematopoietic stem cells under nonmyeloablative conditions show prolonged life spans and allow detailed analysis of human immunodeficiency virus type 1 pathogenesis. J Virol 81(23):13259-13264.
Koyanagi Y, Tanaka Y, Ito M, Yamamoto N. (2008) Humanized mice for human retrovirus infection. Curr Top Microbiol Immunol 324:133-48.
Sato K, Nie C, Misawa N, Tanaka Y, Ito M, Koyanagi Y. (2010) Dynamics of memory and naive CD8+ T lymphocytes in humanized NOD/SCID/IL-2Rgammanull mice infected with CCR5-tropic HIV-1. Vaccine 28 Suppl 2:B32-37.
Sato K, Izumi T, Misawa N, Kobayashi T, Yamashita Y, Ohmichi M, Ito M, Takaori-Kondo A, Koyanagi Y. (2010) Remarkable lethal G-to-A mutations in vif-proficient HIV-1 provirus by individual APOBEC3 proteins in humanized mice. J Virol 84:9546-9556.
Zhang L, Meissner E, Chen J, Su L. (2010) Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis. Sci China Life Sci 53(2):195-203.
Okuma K, Tanaka R, Ogura T, Ito M, Kumakura S, Yanaka M, Nishizawa M, Sugiura W, Yamamoto N, Tanaka Y. (2008) Interleukin-4-Transgenic hu-PBL-SCID Mice: A Model for the Screening of Antiviral Drugs and Immunotherapeutic Agents against X4 HIV-1 Viruses. J Infect Dis 197:134-141.
Amet T, Nonaka M, Dewan MZ, Saitoh Y, Qi X, Ichinose S, Yamamoto N, Yamaoka S. (2008) Statin-induced inhibition of HIV-1 release from latently infected U1 cells reveals a critical role for protein prenylation in HIV-1 replication. Microbes Infect 10:471-480.
Ito M, Koyanagi Y, Terashima K, Yamamoto N, Nakahata T, Ueyama Y, Tamaoki N, Nomura T. (2003) NOG (NOD/Shi-scid, γcnull) mouse-HIV-1 and HTLV-1 infection model using NOG mice allowing an efficient transplantation of human cells. Proc. Japanese Society of Animal Models for Human Diseases 19:23-30. (in Japanese)
Takajo I, Umeki K, Morishita K, Yamamoto I, Kubuki Y, Hatakeyama K, Kataoka H, Okayama A. (2007) Engraftment of peripheral blood mononuclear cells from human T-lymphotropic virus type 1 carriers in NOD/SCID/gammac(null) (NOG) mice. Int J Cancer 121(10):2205-11.
Yamamoto I, Takajo I, Umeki K, Morishita K, Hatakeyama K, Kataoka H, Nomura H, Okayama A. (2010) Multiple integrations of human T-lymphotropic virus type 1 proviruses in the engrafted cells from the asymptomatic carriers in NOD/SCID/gammacnull mice. Intervirology 53:229-239.
Yajima M, Imadome K, Nakagawa A, Watanabe S, Terashima K, Nakamura H, Ito M, Shimizu N, Honda M, Yamamoto N, Fujiwara S. (2008) A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses. J Infect Dis. 198(5):673-82.
Miyake A, Dewan MZ, Ishida T, Watanabe M, Honda M, Sata T, Yamamoto N, Umezawa K, Watanabe T, Horie R. (2008) Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-kappaB inhibitor DHMEQ. Microbes Infect 10:748-756.
Dewan MZ, Tomita M, Katano H, Yamamoto N, Ahmed S, Yamamoto M, Sata T, Mori N, Yamamoto N. (2009) An HIV protease inhibitor, ritonavir targets the nuclear factor-kappaB and inhibits the tumor growth and infiltration of EBV-positive lymphoblastoid B cells. Int J Cancer 124:622-629.
Yajima M, Imadome K, Nakagawa A, Watanabe S, Terashima K, Nakamura H, Ito M, Shimizu N, Yamamoto N, Fujiwara S. (2009) T cell-mediated control of Epstein-Barr virus infection in humanized mice. J Infect Dis 200(10):1611-5.
Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, Koyanagi Y. (2011) A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice. Blood 26;117(21):5663-73.
Andreassen J, Ito A, Ito M, Nakao M, Nakaya K. (2004) Hymenolepis microstoma: direct life cycle in immunodeficient mice. J Helminthol 78(1):1-5.
NOG as superior host for engraftment of human cancer cell lines
Machida K, Suemizu H, Kawai K, Ishikawa T, Sawada R, Ohnishi Y, Tsuchiya T. (2009) Higher susceptibility of NOG mice to xenotransplanted tumors. J Toxicol Sci 34(1):123-7.
NOG as host for engraftment of human primary tumor tissues
Fujii E, Suzuki M, Matsubara K, Watanabe M, Chen YJ, Adachi K, Ohnishi Y, Tanigawa M, Tsuchiya M, Tamaoki N. (2008) Establishment and characterization of in vivo human tumor models in the NOD/SCID/gamma(c)(null) mouse. Pathol Int 58(9):559-67.
Miyakawa Y, Ohnishi Y, Tomisawa M, Monnai M, Kohmura K, Ueyama Y, Ito M, Ikeda Y, Kizaki M, Nakamura M. (2004) Establishment of a new model of human multiple myeloma using NOD/SCID/gammac(null) (NOG) mice. Biochem Biophys Res Commun. 313:258-262.
Dewan Z, Watanabe M, Terashima K, Aoki M, Sata T, Honda M, Ito M, Yamaoka S, Watanabe T, Horie R, Yamamoto N. (2004) Prompt tumor formation and maintenance of constitutive NF-κB activity of multiple myeloma cells in NOD/SCID/gammacnull mice. Cancer Sci 95(7):564-568.
Ikoma N, Yamazaki H, Abe Y, Oida Y, Ohnishi Y, Suemizu H, Matsumoto H, Matsuyama T, Ohta Y, Ozawa A, Ueyama Y, Nakamura M. (2005) S100A4 expression with reduced E-cadherin expression predicts distant metastasis of human malignant melanoma cell lines in the NOD/SCID/gammaCnull (NOG) mouse model. Oncol Rep 14:633-637.
Chijiwa T, Abe Y, Ikoma N, Yamazaki H, Tsukamoto H, Suemizu H, Kawai K, Wakui M, Nishime C, Matsumoto H, Matsuyama M, Mukai M, Ueyama Y, Nakamura M. (2009) Thrombospondin 2 inhibits metastasis of human malignant melanoma through microenvironment-modification in NOD/SCID/gammaCnull (NOG) mice. Int J Oncol 34(1):5-13.
Dewan MZ, Watanabe M, Ahmed S, Terashima K, Horiuchi S, Sata T, Honda M, Ito M, Watanabe T, Horie R, Yamamoto N. (2005) Hodgkin's lymphoma cells are efficiently engrafted and tumor marker CD30 is expressed with constitutive nuclear factor-кB activity in unconditioned NOD/SCID/gammac(null). Cancer Sci 96(8):466-473.
Dewan MZ, Terunuma H, Toi M, Tanaka Y, Katano H, Deng X, Abe H, Nakasone T, Mori N, Sata T, Yamamoto N. (2006) Potential role of natural killer cells in controlling growth and infiltration of AIDS-associated primary effusion lymphoma cells. Cancer Sci 97:1381-1387.
Watanabe M, Dewan MZ, Taira M, Shoda M, Honda M, Sata T, Higashihara M, Kadin ME, Watanabe T, Yamamoto N, Umezawa K, Horie R. (2007) IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells. Lab Invest 87:372-382.
Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H, Inagaki A, Suzuki S, Takino H, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo. J Immunol 183(7):4782-91.
Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F, Takino H, Mori F, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model. Cancer Immunol Immunother 58(8):1195-206.
Kato C, Fujii E, Chen YJ, Endaya BB, Matsubara K, Suzuki M, Ohnishi Y, Tamaoki N. (2009) Spontaneous thymic lymphomas in the non-obese diabetic/Shi-scid, IL-2R gamma (null) mouse. Lab Anim 43(4):402-4.
Shiokawa M, Takahashi T, Murakami A, Kita S, Ito M, Sugamura K, Ishii N. (2010) In vivo assay of human NK-dependent ADCC using NOD/SCID/gammac(null) (NOG) mice. Biochem Biophys Res Commun 399:733-737.
Dewan MZ, Terunuma H, Ahmed S, Ohba K, Takada M, Tanaka Y, Toi M,Yamamoto N. (2005) Natural killer cells in breast cancer cell growth and metastasis in SCID mice. Biomed Pharmacother 59 Suppl 2:S375-379.
Dewan MZ, Terunuma H, Takada M, Tanaka Y, Abe H, Sata T, Toi M, Yamamoto N. (2006) Role of natural killer cells in hormone-independent rapid tumor formation and spontaneous metastasis of breast cancer cells in vivo. Breast Cancer Res Treat 104(3):267-75.
Dewan MZ, Ahmed S, Iwasaki Y, Ohba K, Toi M, Yamamoto N. (2006) Stromal cell-derived factor-1 and CXCR4 receptor interaction in tumor growth and metastasis of breast cancer. Biomed Pharmacother 60:273-276.
Dewan Z, Terashima K, Taruishi M, Hasegawa H, Ito M, Tanaka Y, Mori N, Sata T, Koyanagi Y, Maeda M, Kubuki Y, Okayama A, Fujii M, Yamamoto N. (2003) Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/γc null mice: suppression by an inhibitor against NF-κB. J Virol 77(9):5286-5294.
Nakamura Y, Ito M, Yamamoto T, Yan XY, Yagasaki H, Kamachi Y, Kudo K, Kojima S. (2005) Engraftment of NOD/SCID/gammac(null) mice with multilineage neoplastic cells from patients with juvenile myelomonocytic leukaemia. Br J Haematol. 130(1):51-7.
Dewan MZ, Uchihara J, Terashima K, Honda M, Sata T, Ito M, Fujii N, Uozumi K, Tsukasaki K, Tomonaga M, Kubuki Y, Okayama A, Toi M, Mori N, Yamamoto N. (2006) Efficient intervention of growth and infiltration of primary adult T-cell leukemia cell by an HIV protease inhibitor, ritonavir. Blood 107(2):716-724.
Ninomiya M, Abe A, Yokozawa T, Ozeki K, Yamamoto K, Ito M, Ito M, Kiyoi H, Emi N, Naoe T. (2006) Establishment of a myeloid leuemia cell line, TRL-01, with MLL-ENL fusion gene. Cancer Genet Cytogenet 169:1-11.
Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M,Kiyoi H, Kinoshita T, Naoe T. (2007) Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice. Leukemia 21:136-142.
Saitoh Y, Yamamoto N, Dewan MZ, Sugimoto H, Martinez Bruyn VJ, Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S. (2008) Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells. Blood 111:5118-5129.
Dewan MZ, Takamatsu N, Hidaka T, Hatakeyama K, Nakahata S, Fujisawa J, Katano H, Yamamoto N, Morishita K. (2008) Critical role for TSLC1 expression in the growth and organ infiltration of adult T-cell leukemia cells in vivo. J Virol 82:11958-11963.
Hirosawa T, Torikai H, Yanagisawa M, Kamei M, Imahashi N, Demachi-Okamura A, Tanimoto M, Shiraishi K, Ito M, Miyamura K, Shibata K, Kikkawa F, Morishima Y, Takahashi T, Emi N, Kuzushima K, Akatsuka Y. (2011) Mismatched human leukocyte antigen class II-restricted CD8(+) cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation. Cancer Sci 102(7):1281-6.
Muguruma Y, Matsushita H, Yahata T, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K. (2011) Establishment of a xenograft model of human myelodysplastic syndromes. Haematologica 96(4):543-51.
Suemizu H, Monnai M, Ohnishi Y, Ito M, Tamaoki N, Nakamura M. (2007) Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel new quantitative model of metastasis in NOD/SCID/gammacnull (NOG) mice. Int J Oncol 31(4):741-51.
Hepatocellular carcinoma (HCC)
Kimura O, Takahashi T, Ishii N, Inoue Y, Ueno Y, Kogure T, Fukushima K, Shiina M, Yamagiwa Y, Kondo Y, Inoue J, Kakazu E, Iwasaki T, Kawagishi N, Shimosegawa T, Sugamura K. (2010) Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines. Cancer Sci 101:2145-2155.
Handa K, Ohmura M, Nishime C, Hishiki T, Nagahata Y, Kawai K, Suemizu H, Nakamura M, Wakui M, Kitagawa Y, Suematsu M, Tsukada K. (2010) Phosphorescence-assisted microvascular O(2) measurements reveal alterations of oxygen demand in human metastatic colon cancer in the liver of superimmunodeficient NOG mice. Adv Exp Med Biol 662:423-9.
Hamada K, Monnai M, Kawai K, Nishime C, Kito C, Miyazaki N, Ohnishi Y, Nakamura M, Suemizu H. (2008) Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rγnull (NOG) mice. Int J Oncol 32:153-159.
Suemizu H, Monnai M, Ohnishi Y, Ito M, Tamaoki N, Nakamura M. (2007) Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel new quantitative model of metastasis in NOD/SCID/gammacnull (NOG) mice. Int J Oncol 31(4):741-51.
Hamada K, Monnai M, Kawai K, Nishime C, Kito C, Miyazaki N, Ohnishi Y, Nakamura M, Suemizu H. (2008) Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rgammanull (NOG) mice. J Oncol 32:153-159.
Nakamura M, Suemizu H. (2008) Novel metastasis models of human cancer in NOG mice. Curr Top Microbiol Immunol 324:167-77.
Handa K, Ohmura M, Nishime C, Hishiki T, Nagahata Y, Kawai K, Suemizu H, Nakamura M, Wakui M, Kitagawa Y, Suematsu M, Tsukada K. (2010) Phosphorescence-assisted microvascular O(2) measurements reveal alterations of oxygen demand in human metastatic colon cancer in the liver of superimmunodeficient NOG mice. Adv Exp Med Biol 662:423-9.
Kubo A, Ohmura M, Wakui M, Harada T, Kajihara S, Ogawa K, Suemizu H, Nakamura M, Setou M, Suematsu M. (2011) Semi-quantitative analyses of metabolic systems of human colon cancer metastatic xenografts in livers of superimmunodeficient NOG mice. Anal Bioanal Chem 400(7):1895-904.
Tsuiji K, Takeda T, Li B, Kondo A, Ito M, Yaegashi N. (2010) Establishment of a novel xenograft model for human uterine leiomyoma in immunodeficient mice. Tohoku J Exp Med 222:55-61.
Doshi M, Koyanagi M, Nakahara M, Saeki K, Saeki K, Yuo A. (2006) Identification of human neutrophils during experimentally induced inflammation in mice with transplanted CD34+ cells from human umbilical cord blood. Int J Hematol 84:231-237.
Ninomiya M, Kiyoi H, Ito M, Hirose Y, Naoe T. (2004) Retinoic acid syndrome in NOD/SCID mice induced by injecting an acute promyelocytic leukemia cell line. Leukemia 18:442-448.
Stem cells / Regenerative Medicine / Tissue engineering
Matsuura-Sawada R, Murakami T, Ozawa Y, Nabeshima H, Akahira J, SatoY, Koyanagi Y, Ito M, Terada Y, Okamura K. (2005) Reproduction of menstrual changes in transplanted human endometrial tissue in immunodeficient mice. Hum Reprod 20:1477-1484.
Masuda H, Maruyama T, Hiratsu E, Yamane J, Iwanami A, Nagashima T, Ono M, Miyoshi H, Okano HJ, Ito M, Tamaoki N, Nomura T, Okano H, MatsuzakiY, Yoshimura Y. (2007) Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/gamma c(null) immunodeficient mice. Proc Natl Acad Sci U S A 104:1925-1930.
Ono, M, Maruyama T, Masuda H, Kajitani T, Nagashima T, Arase T, Ito M, Ohta K, Uchida H, Asada H, Yoshimura Y, Okano H, Matsuzaki Y. (2007) Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells. Proc Natl Acad Sci U S A 104(47):18700-5.
Terada Y, Terunuma-Sato Y, Kakoi-Yoshimoto T, Hasegawa H, Ugajin T, Koyanagi Y, Ito M, Murakami T, Sasano H, Yaegashi N, Okamura K. (2008) Development of human Graafian follicles following transplantation of human ovarian tissue into NOD/SCID/gammac null mice. Am J Reprod Immunol 60(6):534-40.
Suemizu H, Hasegawa M, Kawai K, Taniguchi K, Monnai M, Wakui M, Suematsu M, Ito M, Peltz G, Nakamura M. (2008) Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice. Biochem Biophys Res Commun 377(1):248-52.
Oh JY, Kim MK, Ko JH, Lee HJ, Kim Y, Park CS, Park CG, Kim SJ, Wee WR, Lee JH. (200 Acute cell-mediated rejection in orthotopic pig-to-mouse corneal xenotransplantation. Xenotransplantation 16(2):74-82.
Watanabe T, Hayashi H, Kita K, Kubota Y, Ogawa T. (2009) Ectopic porcine spermatogenesis in murine subcutis: tissue grafting versus cell-injection methods. Asian J Androl 11(3):317-23.
Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H. (2010) Stem cell-like properties of the endometrial side population: implication in endometrial regeneration. PLoS One 5:e10387.
Kikuchi-Arai M, Murakami T, Utsunomiya H, Akahira J, Suzuki-Kakisaka H, Terada Y, Tachibana M, Hayasaka S, Ugajin T, Yaegashi N. (2010) Establishment of long-term model throughout regular menstrual cycles in immunodeficient mice. Am J Reprod Immunol 64:324-332.
Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M, Ito M, Suematsu M, Peltz G, Nakamura M (2011) The reconstituted 'humanized liver' in TK-NOG mice is mature and functional. Biochem Biophysical Res Communications 405:405-410.
Yamazaki H, Suemizu H, Igaya S, Shimizu M, Shibata N, Nakamura M. (2011) in vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice. Chem Res Toxicol 24(3):287-9.
Yahata T, Muguruma Y, Yumino S, Sheng Y, Uno T, Matsuzawa H, Ito M, Kato S, Hotta T, Ando K. (2008) Quiescent Human Hematopoietic Stem Cells in the Bone Marrow Niches Organize the Hierarchical Structure of Hematopoiesis. Stem Cells 26:3228-3236.
Kishi Y, Tanaka Y, Shibata H, Nakamura S, Takeuchi K, Masuda S, Ikeda T, Muramatsu S, Hanazono Y. (2008) Variation in the incidence of teratomas after the transplantation of nonhuman primate ES cells into immunodeficient mice. Cell Transplant 17:1095-1102.
Ogawa D, Okada Y, Nakamura M, Kanemura Y, Okano HJ, Matsuzaki Y, Shimazaki T, Ito M, Ikeda E, Tamiya T, Nagao S, Okano H. (2009) Evaluation of Human Fetal Neural Stem/Progenitor Cells as a Source for Cell Replacement Therapy for Neurological Disorders: Properties and Tumorigenicity After Long-Term In Vitro Maintenance. J Neuro Res 87:307-317.
Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, Ando K. (2011) Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells. Blood 118(11):2941-50.
Differentiation of HSC into hepatocytes
Fujino H, Hiramatsu H, Tsuchiya A, Niwa A, Noma H, Shiota M, Umeda K, Yoshimoto M, Ito M, Heike T, Nakahata T. (2007) Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gamma(c)null mice through cell fusion. FASEB J 21:3499-3510.
Hamada K, Monnai M, Kawai K, Nishime C, Kito C, Miyazaki N, Ohnishi Y, Nakamura M, Suemizu H. (2008) Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rgammanull (NOG) mice. Int J Oncol 32:153-159
Therapeutic Efficacy Evaluation
Dewan Z, Terashima K, Taruishi M, Hasegawa H, Ito M, Tanaka Y, Mori N, Sata T, Koyanagi Y, Maeda M, Kubuki Y, Okayama A, Fujii M, Yamamoto N. (2003) Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/γ mice: suppression by an inhibitor against NF-κB. J Virol 77(9):5286-5294.
Nakamura T, Miyakawa Y, Miyamura A, Yamane A, Suzuki H, Ito M, Ohnishi Y, Ishiwata N, Ikeda Y, Tsuruzoe N. (2006) A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood 107(11):4300-4307.
Dewan MZ, Uchihara J, Terashima K, Honda M, Sata T, Ito M, Fujii N, Uozumi K, Tsukasaki K, Tomonaga M, Kubuki Y, Okayama A, Toi M, Mori N, Yamamoto N. (2006) Efficient intervention of growth and infiltration of primary adult T-cell leukemia cell by an HIV protease inhibitor, ritonavir. Blood 107(2):716-724.
Hamada K, Monnai M, Kawai K, Nishime C, Kito C, Miyazaki N, Ohnishi Y, Nakamura M, Suemizu H. (2008) Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rgammanull (NOG) mice. Int J Oncol 32:153-159
Machida K, Suemizu H, Kawai K, Ishikawa T, Sawada R, Ohnishi Y, Tsuchiya T. (2009) Higher susceptibility of NOG mice to xenotransplanted tumors. J Toxicol Sci 34(1):123-7.
Kawaguchi AT, Kametani Y, Kato S, Furuya H, Tamaoki K, Habu S. (2009) Effects of liposome-encapsulated hemoglobin on human immune system: evaluation in immunodeficient mice reconstituted with human cord blood stem cells. Artif Organs 33(2):169-76.
Kai M, Hagiwara T, Emuta C, Chisaka Y, Tsuruhata K, Endo C, Inagaki Y, Miyazaki H, Kataoka S. (2009) in vivo efficacy of anti-MPL agonist antibody in promoting primary human hematopoietic cells. Blood 113(10):2213-6.
Inoue M, Senju S, Hirata S, Irie A, Baba H, Nishimura Y. (2009) An in vivo model of priming of antigen-specific human CTL by Mo-DC in NOD/Shi-scid IL2rgamma(null) (NOG) mice. Immunol Lett 126(1-2):67-72.
Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F, Takino H, Mori F, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model. Cancer Immunol Immunother 58(8):1195-206.
Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H, Inagaki A, Suzuki S, Takino H, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R. (2009) Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo. J Immunol 183(7):4782-91.
Okuma K, Tanaka R, Ogura T, Ito M, Kumakura S, Yanaka M, Nishizawa M, Sugiura W, Yamamoto N, Tanaka Y. (2008) Interleukin-4-Transgenic hu-PBL-SCID Mice: A Model for the Screening of Antiviral Drugs and Immunotherapeutic Agents against X4 HIV-1 Viruses. J Infect Dis 197:134-141.
Hamada K, Monnai M, Kawai K, Nishime C, Kito C, Miyazaki N, Ohnishi Y, Nakamura M, Suemizu H. (2008) Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rγnull (NOG) mice. Int J Oncol 32:153-159.
Machida K, Suemizu H, Kawai K, Ishikawa T, Sawada R, Ohnishi Y, Tsuchiya T. (2009) Higher susceptibility of NOG mice to xenotransplanted tumors. J Toxicol Sci 34(1):123-7.
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