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Express the human tumor necrosis factor α (TNF-α) transgene, a cytokine implicated in the pathogenesis of human rheumatoid arthritis
Exhibits severe chronic arthritis of the forepaws and hind paws, as shown by gross observation and histological analysis by approximately 20 weeks of age
A useful model for studying inflammatory arthritis which does not require experimental manipulation
Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Genetic Background: C57BL/6 Background
Origin: The TNF-α mouse was developed by Xenogen Biosciences, now Taconic. The model was created by microinjecting the human TNF-α gene. Taconic received stock in April 1996 at the second backcross from the C57BL/6 x SJL founder line. The mice were maintained by backcrossing hemizygous TNF-α mice to C57BL/6NTac inbred mice.
Hayward MD, Jones BK, Saparov A, Hain HS, Trillat A-C, Bunzel MM, Corona A, Li-Wang B, Strenkowski B, Giordano C, Shen H, Arcamone E, Weidlick J, Vilensky M, Tugusheva M, Felkner RH, Campbell W, Rao Y, Grass DS, Buiakova O. (2007) An extensive phenotypic characterization of the hTNFα transgenic mice. BMC Physiology, 7:13