Fcer1g - Model 584

Constitutive Knock Out

Fcer1g (Model 584) Constitutive Knock Out Mouse Model

BALB/c Background

  • Model #
  • Genotype
  • Nomenclature
  • 584-F
    C.129P2(B6)-Fcer1gtm1Rav N12
  • 584-M
    C.129P2(B6)-Fcer1gtm1Rav N12
  • Deficient in the gamma chain subunit of the FcgRI, FcgRIII, and FceRI receptors
  • The deleted gamma chain subunit is essential for cell surface expression of these molecules
  • Macrophages, neutrophils, mast cells, basophils, and NK cells are functionally impaired, due to the lack of these Fc receptors
  • The mice have normal T cell thymic and peripheral T cell development
  • Useful in determining the role of structurally similar Fc receptors in mediating effector immune responses and studying the pleiotropic role of the γ chain subunit
  • Exhibit several different types of immunodeficiency making them useful for studies to distinguish the role of the Fc Receptors in antibody-mediated effector responses and to evaluate the contribution of IgG and IgE triggered effector pathways
  • The mice are fertile and develop normally
  • These mice carry the H2d haplotype


The Fcer1g mouse was developed in the laboratory of J.V. Ravetch in 1993. The model was created by targeting the Fcer1g gene in E14 ES cells and injecting the targeted cells into C57BL/6 blastocysts. Heterozygotes on a C57BL/6 background were intercrossed to generate homozygous targeted mutation mice. The mice were then backcrossed twelve generations (N12) to a BALB/cByJ inbred background. Taconic received stock in 1996. The mice were derived by embryo transfer in July 1997 and are maintained by incrossing homozygous mice.


Wildtype for Nnt mutation





Initial Publication:

Takai T, Li M, Sylvestre D, Clynes R, Ravetch J. (1994) FcRγ Chain Deletion results in Pleiotrophic Effector Cell Defects. Cell, 76:519-529.

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Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions of Sale and the following terms of use:
  • Title to these Models and biological materials derived from them remains with Taconic Biosciences, Inc.
  • The Models will be used for research purposes only.
  • The Models will not be bred except to obtain embryos or fetuses required for research purposes
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.