CETP

Random Transgenic

CETP Random Transgenic Mouse Model

  • Model #
  • Genotype
  • Nomenclature
  • 3715-F
    tg/wt
    B6.SJL-Tg(APOA-CETP)1Dsg N11
  • 3715-M
    tg/wt
    B6.SJL-Tg(APOA-CETP)1Dsg N11
  • Contains human cholesteryl ester transfer protein transgene
  • Exhibits dramatic reduction in serum HDL cholesterol
  • Useful for identifying and evaluating compounds that increase HDL cholesterol levels and for atherosclerosis studies
  • Differs from model 1003 in that it has been backcrossed for six additional generations to C57BL/6, thereby reducing genes from the SJL strain

Genetic Background:

B6.SJL Background

Origin:

The CETP mouse was developed in the laboratory of Dr. David Grass at Xenogen Biosciences, now Taconic. The model was created by microinjecting the human CETP gene into (C57BL/6J x SJL) F2 zygotes. Taconic received stock in April 1996 at the second backcross from the founder line. The mice were then backcrossed one generation to C57BL/6 prior to intercrossing for homozygosity. Backcrossing to C57BL/6NTac recommenced at Taconic in 2004. The line was backcrossed a total of 10 generations (N10) and then intercrossed to homozygosity. A homozygous colony is maintained for the production of hemizygotes through mating to C57BL/6NTac (N11).


Genetics:

Wild type for Nnt mutation


Color:

Black

Species:

Mouse

Initial Publication:

Grass, D.S., Saini, U., Felkner, R.H., Wallace, R.E., Lago, W.J.P., Young, S.G., Swanson, M.E. (1995). Transgenic Mice expressing both human apolipoprotein B and human CETP have a lipoprotein cholesterol distribution similar to that of normolipidemic humans. The Journal of Lipid Research, Vol. 36, No. 5, pp. 1082-1090.



Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions of Sale and the following terms of use:
  • Title to these Models and biological materials derived from them remains with Taconic Biosciences, Inc.
  • The Models will be used for research purposes only.
  • The Models will not be bred except to obtain embryos or fetuses required for research purposes
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.