CETP

Random Transgenic

CETP Random Transgenic Mouse Model
EZcohort™ Models
The easiest way to acquire and breed cryopreserved GEMs
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  • Model #
  • Genotype
  • Nomenclature
  • 3715-F
    tg/wt
    B6.SJL-Tg(APOA-CETP)1Dsg N11
  • 3715-M
    tg/wt
    B6.SJL-Tg(APOA-CETP)1Dsg N11
  • Contains human cholesteryl ester transfer protein transgene
  • Exhibits dramatic reduction in serum HDL cholesterol
  • Useful for identifying and evaluating compounds that increase HDL cholesterol levels and for atherosclerosis studies
  • Differs from model 1003 in that it has been backcrossed for six additional generations to C57BL/6, thereby reducing genes from the SJL strain
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Genetic Background:

B6.SJL Background

Origin:

The CETP mouse was developed in the laboratory of Dr. David Grass at Xenogen Biosciences, now Taconic. The model was created by microinjecting the human CETP gene into (C57BL/6J x SJL) F2 zygotes. Taconic received stock in April 1996 at the second backcross from the founder line. The mice were then backcrossed one generation to C57BL/6 prior to intercrossing for homozygosity. Backcrossing to C57BL/6NTac recommenced at Taconic in 2004. The line was backcrossed a total of 10 generations (N10) and then intercrossed to homozygosity. A homozygous colony is maintained for the production of hemizygotes through mating to C57BL/6NTac (N11).


Genetics:

Wild type for Nnt mutation


Color:

Black

Species:

Mouse

Initial Publication:

Grass, D.S., Saini, U., Felkner, R.H., Wallace, R.E., Lago, W.J.P., Young, S.G., Swanson, M.E. (1995). Transgenic Mice expressing both human apolipoprotein B and human CETP have a lipoprotein cholesterol distribution similar to that of normolipidemic humans. The Journal of Lipid Research, Vol. 36, No. 5, pp. 1082-1090.



Conditions of Use for EZcohort™ Models
EZcohort™ models are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic Biosciences, Inc. (Taconic) sells EZcohort™ models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased EZcohort™ models in consideration of purchasers' acknowledgement of and agreement to Taconic's Terms and Conditions for the Sale of Products and the following conditions of use:

  • Title to EZcohort™ models and biological materials derived from them remains with Taconic.
  • EZcohort™ models will be used for research purposes only.
  • EZcohort™ models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
  • Breeders from deliverables can be used for propagation of EZcohort™ models or to cross to other strains.
  • Continuation of breeding and crossbreeding of EZcohort™ models outside Taconicis permitted for a term of three years post-purchase of the EZcohort™ models and is subject to annual confirmation of these EZcohort™ Conditions of Use.

Continuation of breeding and crossbreeding after the three year term will require renewal of the EZcohort™ Conditions of Use and payment of a fee.