ApoB100

Random Transgenic

ApoB100 Random Transgenic Mouse Model

C57BL/6NTac Background

  • Model #
  • Genotype
  • Nomenclature
  • 1004-F
    tg/wt
    B6.SJL-Tg(APOB)1102Sgy N20+?
  • 1004-M
    tg/wt
    B6.SJL-Tg(APOB)1102Sgy N20+?
  • Expresses high levels of human apolipoprotein B100
  • ApoB100 mice show elevated serum levels of LDL cholesterol
  • When fed a high fat diet, will develop significant foam cell accumulation underlying the endothelium and within the media, and develop significantly more complex atherosclerotic lesions than control animals
  • Useful for identifying and evaluating compounds to reduce elevated levels of LDL cholesterol and the risk of atherosclerosis
  • Also useful for studies of lipid transport and atherosclerosis

Genetic Background:

C57BL/6 Background

Origin:

The ApoB100 mouse was developed by MacRae F. Linton et. al. of the Gladstone Institute of Cardiovascular Disease. The model was created by microinjecting the human apolipoprotein B100 gene into C57BL/6J x SJL zygotes. The resultant mice were backcrossed to C57BL/6 for 4 generations (N4). Taconic received stock from Xenogen Biosciences in May 1996. The mice are maintained by backcrossing hemizygous ApoB100 mice with C57BL/6NTac inbred mice.


Genetics:

Wild type for Nnt mutation


Color:

Black

Species:

Mouse

Initial Publication:

Linton MF, Farese RV, Chiesa G, Grass DS, Chin P, Hammer RE, Hobbs HH, Young SG. (1993). Transgenic Mice Expressing High Plasma Concentrations of Human Apolipoproteins B100 and Lipoprotein (a). J Clin Invest, 92: 3029-3037.



Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions of Sale and the following terms of use:
  • Title to these Models and biological materials derived from them remains with Taconic Biosciences, Inc.
  • The Models will be used for research purposes only.
  • The Models will not be bred except to obtain embryos or fetuses required for research purposes
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.