Immunodeficient Models INSIGHTS

Three reasons you shouldn't use heterozygous nude mice or rats as sentinels

If you are reading this you already know that the use of sentinel animals in research and production colonies is critical to facilitate health monitoring and maintain animal quality. A sentinel animal must have a strong but not excessive immune response to infectious agents, with the ability to seroconvert to viral agents. You are also probably aware that commonly used models include: the hearty outbred Swiss Webster...

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scid mutants or Rag2 knockouts - Which immunodeficient model is best for your study?

Mice with compromised immune systems are invaluable research tools. Starting with the discovery of athymic nude mice in the 1960's, the portfolio of immunodeficient rodents has grown significantly. Although these models are used quite widely, not all researchers understand their intrinsic characteristics and how those characteristics impact experimental outcomes. Learn more about two key immunodeficient models, scid mutants and Rag2 knockouts, and how to choose the most...

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Obstacles to efficacy testing of biologic therapies in mice - anti-drug antibody development

Biologic drugs such as monoclonal antibodies or RNA therapies can trigger immune reactions (immunogenicity) upon treatment. Such immune reactions can result in toxicity. Aside from potential safety problems, the immune reaction can also reduce the efficacy of the biologic drug. Production of neutralizing anti-drug antibodies (ADA) in small animal models used for efficacy testing can result in decreased circulating levels of the drug and reduced efficacy. This...

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