Taconic


tADMET
A unique and evolving portfolio of translational (humanized & knockout) mouse models, in vitro tools and services for an improved prediction of the Absorption, Distribution, Metabolism, Excretion, and Toxicity characteristics of new compounds in humans.

tADMET Components
Applications
Your Benefits
Humanized and knockout mice of ADMET related genes FRG™ KO Technology Human upcyte® Hepatocytes

Carcinogenicity models tADMET™ Contract Services
  • Drug-drug interactions
  • Human metabolite testing
  • Assessment of bioavailability and clearance
  • PKPD modeling
  • Carcinogenicity testing
  • Infectious diseases
  • Drug Metabolism
  • Toxicity testing
  • Improved drug candidate selection
  • Higher clinical success rates
  • Reduced costs
  • Support drug approval by regulators
  • Support of scientific publications
New Products Latest Publications Free Downloads

tADMET™ Products at a Glance
 

Genetically Engineered Mice
Xenoreceptor Panel Cytochrome P450 Panel Phase 2 Transporter Panel
Knockouts Humanized Knockouts Humanized Humanized Knockouts Humanized
Ahr AHR Cyp1a1/1a2* CYP1A1/1A2* UGT1A1*1** Bcrp BCRP**
Car CAR Cyp2c CYP2C9   Mdr1a  
Pparα   Cyp2d CYP2D6   Mdr1a/b MDR1**
Pxr PXR Cyp3a (7-gene) CYP3A4/3A7   Mdr1a/b-Bcrp  
Pxr-Car PXR-CAR Cyp3a (8-gene) Liver CYP3A4   Mrp1  
Pxr-Car-Ahr PXR-CAR-AHR*   Gut CYP3A4   Mrp2 MRP2
Pxr-Car-Pparα* PXR-CAR-PPARα*   Liver & Gut CYP3A4   Oatp1a/1b OATP1B1
    Cyp2c-Cyp2d-Cyp3a*       OATP1B3
            OATP1B1-1B3
          Oct1/2  
Composite Models (Humanized) Carcinogenicity Models Related Models
PXR-CAR-CYP3A4/3A7 rasH2 HRN™
PXR/CAR/CYP3A4/3A7/CYP2D6* TSG-p53® (N5) Mouse HRN™ nude
PXR/CAR/CYP3A4/3A7/CYP2D6/CYP2C9**    
Tissue Humanized Models Human Hepatocytes
FRG™ KO technology offered in collaboration with Yecuris™ Corporation HepaCur™ human hepatocytes (in partnership with Yecuris™ Corporation)
  upcyte® human Hepatocytes (in partnership with Medicyte GmbH)

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** Coming soon