Michael Hayward, PhD
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The B6 diet induced obese
(DIO) mouse is a well established model for research in metabolism and obesity.
We undertook an extensive phenotypic analysis of metabolic characteristics in three substrains of C57BL/6: C57BL/6NTac, C57BL/6J, and C57BL/6JBom on a low fat diet and a high fat diet (HFD) with conditioning at multiple locations.
We found that the B6NTac DIO mice were heavier and gained weight more quickly than the B6J DIO's at matched ages and when at the same or different conditioning sites.
The relative differences in body weight between the B6NTac and B6J substrains were consistent, regardless of the HFD conditioning location.
There was no difference in body weights among the B6NTac, B6J, and B6JBom on the regular diet.
There were differences in insulin levels, and insulin resistance was greatest in both B6NTac DIO groups.
In summary, it appeared that the B6NTac substrain develops obesity and insulin resistance to a greater extent than the diet-and age-matched B6J and B6JBom mice.
More about Michael Hayward, PhD
- PhD from Columbia University
- BA from Oberlin College
- Post-doctoral Fellow, Vollum Institute, Oregon Health Sciences University
- Research Asst. Professor, Vollum Insitute
- Research Asst. Professor, Center for the Study of Weight Regulation, Oregon Health Sciences University
Behavioral Neuroscience, Obesity, and Diabetes